Louis-Philippe Leroux, Institut national de la recherche scientifique

Research

Canadian Parasitology Network First Annual Symposium Host - Parasite Interactions Infectious Diseases Parasitic Infections Student Intiative

Latest papers

Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanisms.
Frontiers in cellular and infection microbiology · 2025
Leukemia inhibitory factor drives transcriptional programs that promote lipid accumulation and M2 polarization in macrophages.
Journal of leukocyte biology · 2024
Toxoplasma gondii infection induces the expression of the chemokine CXCL16 in macrophages to promote chemoattraction of CXCR6+ cells.
Infection and immunity · 2024 · first author

All 12 publications

Latest funding

1st Canadian Parasitology Network Symposium
CIHR · 2023 · Principal investigator
$19,708

All 1 grants and awards

12 publications.

01

Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanisms.

Lebourg A, Leroux LP, Chaparro V, Chagneau S, Vaillancourt C, Jaramillo M

Frontiers in cellular and infection microbiology2025

DOI: 10.3389/fcimb.2025.1651142 PMID: 41450565

02

Leukemia inhibitory factor drives transcriptional programs that promote lipid accumulation and M2 polarization in macrophages.

Chaparro V, Leroux LP, Lebourg A, Chagneau S, Graber TE, Alain T, Jaramillo M

Journal of leukocyte biology2024

DOI: 10.1093/jleuko/qiae178 PMID: 39178293

03

Toxoplasma gondii infection induces the expression of the chemokine CXCL16 in macrophages to promote chemoattraction of CXCR6+ cells.

Leroux L-P, Chaparro V, Plouffe A, Johnston B, Jaramillo M

Infection and immunity2024First author

DOI: 10.1128/iai.00309-24 PMID: 39436058

04

Toxoplasma gondii inhibits the expression of autophagy-related genes through AKT-dependent inactivation of the transcription factor FOXO3a.

Diez AF, Leroux LP, Chagneau S, Plouffe A, Gold M, Chaparro V, Jaramillo M

mBio2023

DOI: 10.1128/mbio.00795-23 PMID: 37387601

05

Leishmania donovani Exploits Tunneling Nanotubes for Dissemination and Propagation of B Cell Activation.

Stögerer T, Silva-Barrios S, Carmona-Pérez L, Swaminathan S, Mai LT, Leroux LP, Jaramillo M, Descoteaux A, Stäger S

Microbiology spectrum2023

DOI: 10.1128/spectrum.05096-22 PMID: 37404188

06

Cap-dependent translation initiation monitored in living cells.

Gandin V, English BP, Freeman M, Leroux LP, Preibisch S, Walpita D, Jaramillo M, Singer RH

Nature communications2022

DOI: 10.1038/s41467-022-34052-8 PMID: 36323665

07

Infection by the Protozoan Parasite Toxoplasma gondii Inhibits Host MNK1/2-eIF4E Axis to Promote Its Survival.

Leroux LP, Chaparro V, Jaramillo M

Frontiers in cellular and infection microbiology2020First author

DOI: 10.3389/fcimb.2020.00488 PMID: 33014898

08

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts.

Chaparro V, Leroux LP, Masvidal L, Lorent J, Graber TE, Zimmermann A, Arango Duque G, Descoteaux A, Alain T, Larsson O, Jaramillo M

PLoS pathogens2020

DOI: 10.1371/journal.ppat.1008291 PMID: 32479529

09

Leishmania donovani Lipophosphoglycan Increases Macrophage-Dependent Chemotaxis of CXCR6-Expressing Cells via CXCL16 Induction.

Chaparro V, Leroux LP, Zimmermann A, Jardim A, Johnston B, Descoteaux A, Jaramillo M

Infection and immunity2019

DOI: 10.1128/iai.00064-19 PMID: 30804103

10

Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.

Leroux LP, Nasr M, Valanparambil R, Tam M, Rosa BA, Siciliani E, Hill DE, Zarlenga DS, Jaramillo M, Weinstock JV, Geary TG, Stevenson MM, Urban JF, Mitreva M, Jardim A

Scientific reports2018First author

DOI: 10.1038/s41598-018-34174-4 PMID: 30374177

1st Canadian Parasitology Network Symposium

Principal investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Jaramillo, Maritza; Leroux, Louis-Philippe; Pushpker, Rajnigandha; Sergerie, Audrey; Stögerer, Tanja

Keywords: Canadian Parasitology Network; First Annual Symposium; Host - Parasite Interactions; Infectious Diseases; Parasitic Infections; Student Intiative

$19,708

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Centre Armand-Frappier Santé Biotechnologie
Biochemistry, Microbiology and Immunology
INRS-Institut Armand-Frappier (Laval)
Pediatrics

Co-authors at Institut national de la recherche scientifique, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Maritza Jaramillo

Centre Armand-Frappier Santé Biotechnologie

12 shared papers, latest 2025

Tommy Alain

Biochemistry, Microbiology and Immunology

4 shared papers, latest 2024

Albert Descoteaux

INRS-Institut Armand-Frappier (Laval)

3 shared papers, latest 2023

Brent Johnston

Pediatrics

2 shared papers, latest 2024

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Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Canadian Parasitology Network Dear Professor Leroux, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Toxoplasma gondii infection inhibits invasion and migration of human extravillous trophoblasts through dysregulation of FOXO1- and FOXO3a-dependent and -independent mechanisms." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "1st Canadian Parasitology Network Symposium" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]