Faculty profile

Brent Johnston

ResearcherPediatricsDalhousie University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Dalhousie University directory, so their courses may be missing. Find their university profile.

Brent Johnston

Researcher

Pediatrics

Health Sciences

Dalhousie University

Halifax, Nova Scotia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
9 publications in the last five years, latest in 2024.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2018.
Supervised 3 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Arthritis Chemokines Human Immunology Immunogenetics Innate Immunity Interferons Lupus Animal Models

Latest papers

Toxoplasma gondii infection induces the expression of the chemokine CXCL16 in macrophages to promote chemoattraction of CXCR6+ cells.
Infection and immunity · 2024
Canadian National Pancreas Conference 2023: A Review of Multidisciplinary Engagement in Pancreatic Cancer Care.
Current oncology (Toronto, Ont.) · 2024
Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response.
Frontiers in immunology · 2024

All 37 publications

Latest funding

Fusogenic oncolytic virus therapy in combination with immune checkpoint inhibition and natural killer T cell immunotherapy for treatment of primary and metastatic lung cancer
CIHR · 2023 · Supervisor
$105,000
Determining how PRP4K insufficiency impacts cancer signaling and therapy responses
CIHR · 2023 · Co-investigator
$1,178,100
Defining critical pathways of innate immunity for precision therapy of autoimmune diseases
CIHR · 2018 · Principal investigator
$20,000

All 9 grants and awards

37 publications.

Toxoplasma gondii infection induces the expression of the chemokine CXCL16 in macrophages to promote chemoattraction of CXCR6+ cells.

Leroux L-P, Chaparro V, Plouffe A, Johnston B, Jaramillo M

Infection and immunity2024

DOI: 10.1128/iai.00309-24 PMID: 39436058

Canadian National Pancreas Conference 2023: A Review of Multidisciplinary Engagement in Pancreatic Cancer Care.

Nickerson JL, Cyr C, Arseneau RJ, Lee SN, Condon-Oldreive S, Zogopoulos G, Roberts K, Kim CA, Ng SSW, Haider M, Villalba E, Stephenson L, Tsang E, Johnston B, Gala-Lopez B, Cooper V, Hannon B, Gangloff A, Gill S, Servidio-Italiano F, Ramjeesingh R

Current oncology (Toronto, Ont.)2024

DOI: 10.3390/curroncol31100461 PMID: 39451765

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response.

Nickerson R, Thornton CS, Johnston B, Lee AHY, Cheng Z

Frontiers in immunology2024

DOI: 10.3389/fimmu.2024.1405376 PMID: 39015565

Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer.

Nelson A, McMullen N, Gebremeskel S, De Antueno R, Mackenzie D, Duncan R, Johnston B

Breast cancer research : BCR2024Senior author

DOI: 10.1186/s13058-024-01818-5 PMID: 38750591

Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.

McKeown BT, Relja NJ, Hall SR, Gebremeskel S, MacLeod JM, Veinotte CJ, Bennett LG, Ohlund LB, Sleno L, Jakeman DL, Berman JN, Johnston B, Goralski KB

Canadian journal of physiology and pharmacology2023

DOI: 10.1139/cjpp-2023-0026 PMID: 36847292

Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.

McKeown BT, Relja NJ, Hall SR, Gebremeskel S, MacLeod JM, Veinotte CJ, Bennett LG, Ohlund LB, Sleno L, Jakeman DL, Berman JN, Johnston B, Goralski KB

Canadian journal of physiology and pharmacology2022

DOI: 10.1139/cjpp-2022-0152 PMID: 35985040

Editorial: Cytokine and cytokine receptor-based immunotherapies: Updates, controversies, challenges, and future perspectives.

Wang J, Johnston B, Berraondo P

Frontiers in immunology2022

DOI: 10.3389/fimmu.2022.985326 PMID: 35958607

Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation.

Westhaver LP, Nersesian S, Nelson A, MacLean LK, Carter EB, Rowter D, Wang J, Gala-Lopez BL, Stadnyk AW, Johnston B, Boudreau JE

Cell reports2022

DOI: 10.1016/j.celrep.2022.110847 PMID: 35613582

Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression

Nelson A, Gebremeskel S, Lichty BD, Johnston B

Journal for ImmunoTherapy of Cancer202249 citationsSenior authorOpen Access

DOI: 10.1136/jitc-2021-003923 PMID: W4214902204

The Current Landscape of NKT Cell Immunotherapy and the Hills Ahead.

Nelson A, Lukacs JD, Johnston B

Cancers2021Senior author

DOI: 10.3390/cancers13205174 PMID: 34680322

Fusogenic oncolytic virus therapy in combination with immune checkpoint inhibition and natural killer T cell immunotherapy for treatment of primary and metastatic lung cancer

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Lukacs, Jordan D

Keywords: Cancer Immunotherapy; Immune Checkpoint Blockade; Lung Cancer; Natural Killer T Cell; Oncolytic Virus

$105,000

Determining how PRP4K insufficiency impacts cancer signaling and therapy responses

Co-investigatorCIHR2023Project Grant

Principal investigators: Dellaire, Graham P

Keywords: Anoikis; Breast And Cervical Cancer; Chemotherapy; Confocal Microscopy; Growth Factor Signaling; Oxidative Stress Signaling; Pre-Mrna Splicing; Proximity Proteomics; Prp4k; Tissue Microarrays

$1,178,100

Defining critical pathways of innate immunity for precision therapy of autoimmune diseases

Principal investigatorCIHR2018Team Grant: Human Immunology - LOI - Autoimmune diseases related to IMHA pool

Principal investigators: Issekutz, Thomas B; Huber, Adam M; Barsalou, Julie; Boudreau, Jeanette E; Derfalvi, Beata; Haddad, Elie; Hanly, John G; Johnston, Brent; Kelvin, David J; Marshall, Jean S; Ritz, Stacey A; Touzot, Fabien; Turvey, Stuart E; Wang, Jun

Keywords: Arthritis; Human Immunology; Immunogenetics; Innate Immunity; Interferons; Lupus

$20,000

Examining the role of Natural Killer T cells in Rheumatoid Arthritis

SupervisorCIHR2017Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Walker, Brynn A

Keywords: Arthritis; Chemokine Receptors; Cytokine; Inflammation; Natural Killer T Cells

$5,000

Combined cancer therapy with NKT cell activation and oncolytic viruses

Nominated PICIHR2016Project Grant

Principal investigators: Johnston, Brent

Keywords: Animal Models; Chemokines; Cytokines; Cytotoxicity; Dendritic Cell (Dc); Flow Cytometry; Immunosuppression; Immunotherapy; Natural Killer T (Nkt) Cell; Oncolytic Virus

$684,675

NKT cell immunotherapy for breast cancer

SupervisorCIHR2014Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Gebremeskel, Simon Y

Keywords: Breast Cancer; Chemotherapy; Immuno-Oncology; Immunotherapy; Natural Killer T Cells

$105,000

Restitution Enhancement in Arthritis and Chronic Heart disease

Principal investigatorCIHR2013Team Grant: Health Challenges in Chronic Inflammation Initiative - (Full Appl)

Principal investigators: Marshall, Jean S; Bezuhly, Michael; Eklund, Kari K; Hanly, John G; Issekutz, Thomas B; Johnston, Brent; Legare, Jean-François; Lin, Tong-Jun; McDougall, Jason J

Keywords: Arthritis; Cell Migration; Chemokines; Heart Disease; Immunology; Inflammation; Mast Cells

$2,337,154

Mechanisms of natural killer T (NKT) cell development, homing, and activation

Nominated PICIHR2010Operating Grant

Principal investigators: Johnston, Brent

Keywords: Chemokine Receptors; Dendritic Cells; Gpcr Signaling; Leukocyte Homing; Metastasis; Nkt Cells

$755,141

The Terry Fox Foundation Strategic Health Research Training Program in Cancer Research at CIHR

Principal investigatorCIHR2008Terry Fox Foundation Training Grant in Cancer Research at CIHR -Full application

Principal investigators: Johnston, Gerald C; Fernandez, Conrad V; Hoskin, David; Jakeman, David L; Johnston, Brent; Kulka, Marianna; Lee, Patrick W; Marshall, Jean S; Miedema, Baukje; Parker, Louise

Keywords: Cancer; Effective Communication Skills; Problem-Based Learning; Professional Development; Transdisciplinary Approaches

$300,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Brent Johnston

Research

Latest papers

Latest funding

Toxoplasma gondii infection induces the expression of the chemokine CXCL16 in macrophages to promote chemoattraction of CXCR6+ cells.

Canadian National Pancreas Conference 2023: A Review of Multidisciplinary Engagement in Pancreatic Cancer Care.

Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response.

Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer.

Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.

Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models.

Editorial: Cytokine and cytokine receptor-based immunotherapies: Updates, controversies, challenges, and future perspectives.

Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation.

Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression

The Current Landscape of NKT Cell Immunotherapy and the Hills Ahead.

Fusogenic oncolytic virus therapy in combination with immune checkpoint inhibition and natural killer T cell immunotherapy for treatment of primary and metastatic lung cancer

Determining how PRP4K insufficiency impacts cancer signaling and therapy responses

Defining critical pathways of innate immunity for precision therapy of autoimmune diseases

Examining the role of Natural Killer T cells in Rheumatoid Arthritis

Combined cancer therapy with NKT cell activation and oncolytic viruses

NKT cell immunotherapy for breast cancer

Restitution Enhancement in Arthritis and Chronic Heart disease

Mechanisms of natural killer T (NKT) cell development, homing, and activation

The Terry Fox Foundation Strategic Health Research Training Program in Cancer Research at CIHR

Frequent collaborators

Michael Bezuhly

Jun Wang

Louis-Philippe Leroux

Maritza Jaramillo

Zhenyu Cheng

Roy Duncan

Tong-Jun Lin

Breffni Hannon

Anne Gangloff

Graham Dellaire

Christopher Richardson

Douglas Mahoney

Brian Lichty

Albert Descoteaux

Thomas Issekutz