Anne-Marie Lauzon, McGill University

Research

Asthma Muscle Mechanics Smooth Muscle Biophysics Airway Hyperresponsiveness Airway Resistance Alarmins Cd4+ T Cells

Latest papers

Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived macrophages during influenza A infection.
Mucosal immunology · 2025
Serum Response Factor Expression in Excess Permits a Dual Contractile-Proliferative Phenotype of Airway Smooth Muscle.
American journal of respiratory cell and molecular biology · 2024
Induction of a memory-like CD4+ T-cell phenotype by airway smooth muscle cells.
European journal of immunology · 2024

All 41 publications

Latest funding

Smooth muscle biophysics
NSERC · 2024 · Principal investigator
$54,000
CD4+T Cells, Alarmins and Human Airway Smooth Muscle Function in Asthma
CIHR · 2022 · Nominated PI
$807,076
High-throughput tissue mechanics testing apparatus in an incubator environment: the prototype
NSERC · 2017 · Principal investigator
$97,632

All 14 grants and awards

41 publications.

01

Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived macrophages during influenza A infection.

Chakraborty R, Chronopoulos J, Sun R, Morozan A, Joy S, Divangahi M, Lauzon AM, Martin JG

Mucosal immunology2025

DOI: 10.1016/j.mucimm.2025.04.008 PMID: 40319941

02

Serum Response Factor Expression in Excess Permits a Dual Contractile-Proliferative Phenotype of Airway Smooth Muscle.

Sun R, Pan X, Ward E, Intrevado R, Morozan A, Lauzon AM, Martin JG

American journal of respiratory cell and molecular biology2024

DOI: 10.1165/rcmb.2024-0081oc PMID: 38775474

03

Induction of a memory-like CD4+ T-cell phenotype by airway smooth muscle cells.

Jang JH, Zhou M, Makita K, Sun R, El-Hajjar M, Fonseca G, Lauzon AM, Martin JG

European journal of immunology2024

DOI: 10.1002/eji.202249800 PMID: 38334162

04

A method for isolating contractile smooth muscle cells from cryopreserved tissue.

Schultz MLC, Seth P, Kachmar L, Ijpma G, Lauzon AM

American journal of physiology. Cell physiology2024Senior author

DOI: 10.1152/ajpcell.00442.2023 PMID: 38314725

05

CD4+ T cell-derived IFN-γ and LIGHT synergistically upregulate chemokine production from airway smooth muscle cells.

Zhou M, Sun R, Chakraborty R, Wang C, Lauzon AM, Martin JG

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

DOI: 10.1096/fj.202301428rr PMID: 38193542

06

Automated, high temporal resolution mechanics measurements during incubation of contractile tissues.

Ijpma G, Lauzon AM

Journal of biomechanics2023Senior author

DOI: 10.1016/j.jbiomech.2023.111577 PMID: 37058766

07

Airway smooth muscle function in asthma.

Xiong DJP, Martin JG, Lauzon AM

Frontiers in physiology2022Senior author

DOI: 10.3389/fphys.2022.993406 PMID: 36277199

08

Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation.

Hammell MJ, Kachmar L, Balassy Z, IJpma G, Lauzon AM

The Journal of general physiology2022Senior author

DOI: 10.1085/jgp.202213117 PMID: 36001043

09

Interferon-γ amplifies airway smooth muscle-mediated CD4+ T cell recruitment by promoting the secretion of C-X-C-motif chemokine receptor 3 ligands.

Sun R, Jang JH, Lauzon AM, Martin JG

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

DOI: 10.1096/fj.202001480r PMID: 33337555

10

Intrapulmonary airway smooth muscle is hyperreactive with a distinct proteome in asthma.

Ijpma G, Kachmar L, Panariti A, Matusovsky OS, Torgerson D, Benedetti A, Lauzon AM

The European respiratory journal2020Senior author

DOI: 10.1183/13993003.02178-2019 PMID: 32299863

Smooth muscle biophysics

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Lauzon, Anne-Marie

Keywords: smooth muscle; molecular mechanics; myosin; actin; latch state; force; velocity; laser trap; in vitro motility; myosin light chain phosphatase

$54,000

CD4+T Cells, Alarmins and Human Airway Smooth Muscle Function in Asthma

Nominated PICIHR2022Project Grant

Principal investigators: Lauzon, Anne-Marie

Keywords: Airway Resistance; Alarmins; Asthma; Biophysics; Cd4+ T Cells; Contractile Proteins; Hypercontractility; Hyperresponsiveness; Muscle Mechanics; Smooth Muscle

$807,076

High-throughput tissue mechanics testing apparatus in an incubator environment: the prototype

Principal investigatorNSERC2017Collaborative Research and Development Grants

Principal investigators: Lauzon, AnneMarie

$97,632

Asthmatic phenotyping by microfluidic assessment of shortening velocity and contractile force of airway smooth muscle cells obtained from biopsies

Nominated PICIHR2017Project Grant

Principal investigators: Lauzon, Anne-Marie

Keywords: Airway Hyperresponsiveness; Asthma; Biophysics; Cell; Contractile Force; Diagnostics; Microfluidics; Muscle Mechanics; Smooth Muscle; Velocity Of Shortening

$673,200

Establishing the role of airway smooth muscle in human asthma and its potential as a target for therapy

Nominated PICIHR2016Project Grant

Principal investigators: Lauzon, Anne-Marie

Keywords: Airway Hyperresponsiveness; Asthma; Cytokine; Inflammation; Muscle Mechanics; Smooth Muscle; T Cell

$688,051

High-throughput tissue mechanics testing apparatus in an incubator environment

Principal investigatorNSERC2016Engage Grants Program

Principal investigators: Lauzon, AnneMarie

$25,000

Smooth muscle molecular mechanics

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Lauzon, AnneMarie

$280,000

Smooth muscle molecular mechanics

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Lauzon, AnneMarie

$230,000

Smooth Muscle Mechanics in Airway Hyperresponsiveness and Asthma

Nominated PICIHR2009Operating Grant

Principal investigators: Lauzon, Anne-Marie

Keywords: Actin; In Vitro Motility Assay; Myosin Heavy Chain; Myosin Light Chain Phosphorylation; Quick Release Assay; Sm22

$662,985

CIHR - Quebec Respiratory Health Training Program

Co-investigatorCIHR2008Training Grant

Principal investigators: Maltais, François; Berthiaume, Yves; Martin, James G; Rousseau, Eric C; Schwartzman, Kevin

Keywords: Knowledge Transfer; Respiratory Biology; Respiratory Epidemiology And Health; Student Exchange Programs; Transdisciplinary Training And Research

$1,950,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Infectious Diseases
Sciences cliniques
Biomedical Engineering
Kinesiology and Physical Education
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Andrea Benedetti

Infectious Diseases

7 shared papers, latest 2020

Jean-Pierre Lavoie

Sciences cliniques

3 shared papers, latest 2018

Dilson Rassier

Kinesiology and Physical Education

1 shared papers, latest 2013

David Juncker

Biomedical Engineering

1 shared papers, latest 2015

Brian Chen

Medicine

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Asthma Dear Professor Lauzon, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived macrophages during influenza A infection." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Smooth muscle biophysics" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Anne-Marie Lauzon

Research

Latest papers

Latest funding

Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived macrophages during influenza A infection.

Serum Response Factor Expression in Excess Permits a Dual Contractile-Proliferative Phenotype of Airway Smooth Muscle.

Induction of a memory-like CD4+ T-cell phenotype by airway smooth muscle cells.

A method for isolating contractile smooth muscle cells from cryopreserved tissue.

CD4+ T cell-derived IFN-&#x3b3; and LIGHT synergistically upregulate chemokine production from airway smooth muscle cells.

Automated, high temporal resolution mechanics measurements during incubation of contractile tissues.

Airway smooth muscle function in asthma.

Molecular-level evidence of force maintenance by smooth muscle myosin during LC20 dephosphorylation.

Interferon-&#x3b3; amplifies airway smooth muscle-mediated CD4+ T cell recruitment by promoting the secretion of C-X-C-motif chemokine receptor 3 ligands.

Intrapulmonary airway smooth muscle is hyperreactive with a distinct proteome in asthma.

Smooth muscle biophysics

CD4+T Cells, Alarmins and Human Airway Smooth Muscle Function in Asthma

High-throughput tissue mechanics testing apparatus in an incubator environment: the prototype

Asthmatic phenotyping by microfluidic assessment of shortening velocity and contractile force of airway smooth muscle cells obtained from biopsies

Establishing the role of airway smooth muscle in human asthma and its potential as a target for therapy

High-throughput tissue mechanics testing apparatus in an incubator environment

Smooth muscle molecular mechanics

Smooth muscle molecular mechanics

Smooth Muscle Mechanics in Airway Hyperresponsiveness and Asthma

CIHR - Quebec Respiratory Health Training Program

Frequent collaborators

Andrea Benedetti

Andrea Benedetti

Jean-Pierre Lavoie

Dilson Rassier

David Juncker

Maziar Divangahi

Brian Chen

CD4+ T cell-derived IFN-γ and LIGHT synergistically upregulate chemokine production from airway smooth muscle cells.

Interferon-γ amplifies airway smooth muscle-mediated CD4+ T cell recruitment by promoting the secretion of C-X-C-motif chemokine receptor 3 ligands.