Claire Brown, McGill University

Research

Confocal Microscopy Fluorescence Cell Adhesion Cell Mechanics Cell Movement (Migration)Cytoskeleton (Alpha-Actinin)Extracellular Matrix (Substrate Engineering)Image Correlation Microscopy (Icm)

Latest papers

Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.
eLife · 2023
Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA.
ACS chemical biology · 2011
Direct interorganellar transfer of iron from endosome to mitochondrion.
Blood · 2007

All 3 publications

Latest funding

Elucidating how paxillin phosphorylation regulates adhesion dynamics and cell migration
NSERC · 2024 · Principal investigator
$67,000
Understanding the mechanisms that regulate vasculature changes in highly invasive brain cancer using expansion miscroscopy
CIHR · 2023 · Supervisor
$6,000
Controlling cellular and organismal microenvironment using light
NSERC · 2021 · Co-investigator
$150,000

All 16 grants and awards

3 publications.

01

Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.

Ayoubi R, Ryan J, Biddle MS, Alshafie W, Fotouhi M, Bolivar SG, Ruiz Moleon V, Eckmann P, Worrall D, McDowell I, Southern K, Reintsch W, Durcan TM, Brown C, Bandrowski A, Virk H, Edwards AM, McPherson P, Laflamme C

eLife2023

DOI: 10.7554/elife.91645 PMID: 37995198

02

Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA.

Wahba AS, Azizi F, Deleavey GF, Brown C, Robert F, Carrier M, Kalota A, Gewirtz AM, Pelletier J, Hudson RH, Damha MJ

ACS chemical biology2011

DOI: 10.1021/cb200070k PMID: 21667942

03

Direct interorganellar transfer of iron from endosome to mitochondrion.

Sheftel AD, Zhang AS, Brown C, Shirihai OS, Ponka P

Blood2007

DOI: 10.1182/blood-2007-01-068148 PMID: 17376890

Elucidating how paxillin phosphorylation regulates adhesion dynamics and cell migration

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Brown, Claire

Keywords: cell migration; adhesion; quantitative methods; stimulated emission depletion (sted); protein dynamics/interactions; fair image data; phototoxicity; cell health; paxilin; focal adhesion kinase

$67,000

Understanding the mechanisms that regulate vasculature changes in highly invasive brain cancer using expansion miscroscopy

SupervisorCIHR2023Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Woo, Natalie

Keywords: Brain Cancer; Expansion Microscopy; Metastatic Cancer; Protein Factors; Super-Resolution Microscopy; Vasculature Changes

$6,000

Controlling cellular and organismal microenvironment using light

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Hayer, Arnold

$150,000

COVID19 tools to enable contact free advanced microscopy, remote training and technical support while maintaining physical distancing._x000d_ _x000d_ _x000d_ _x000d_

Principal investigatorNSERC2020Alliance Grants

Principal investigators: Brown, Claire Marie

$50,000

Advanced light microscopy methods to study the molecular mechanisms regulating cell adhesion and migration

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Brown, Claire

$192,000

Scientific Platform Corporate Relationships Workshop

Principal investigatorNSERC2018Connect Grants Level 2

Principal investigators: Brown, ClaireMarie

$8,900

Determination of optimal conditions to minimize dye photo-bleaching and photo-toxicity using a resonant confocal laser scanning microscope (rCLSM).

Principal investigatorNSERC2016Engage Grants Program

Principal investigators: Brown, ClaireMarie

$25,000

Biophysical Tools for the Characterization of Breast Cancer Cell Migration and Invasion

Principal investigatorNSERC2016Collaborative Health Research Projects

Principal investigators: Brown, ClaireMarie

$272,500

Bioengineering Facility for Confocal Rheology

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Ehrlicher, Allen

$150,000

Biophysical Tools for the Characterization of Breast Cancer Cell Migration and Invasion

Nominated PICIHR2015Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Brown, Claire M; Siegel, Peter M

Keywords: Cell Adhesion; Cell Mechanics; Cell Movement (Migration); Cytoskeleton (Alpha-Actinin); Extracellular Matrix (Substrate Engineering); Image Correlation Microscopy (Icm); Lipoma Preferred Partner (Lpp); Protein Dynamics & Interactions; Spinning Disk Confocal Microscope (Sdcm); Traction Force Microscopy (Tfm)

$272,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology
Biochemistry
Neurology and Neurosurgery

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Jerry Pelletier

Biochemistry

1 shared papers, latest 2011

Peter McPherson

Neurology and Neurosurgery

1 shared papers, latest 2023

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Confocal Microscopy Dear Professor Brown, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Elucidating how paxillin phosphorylation regulates adhesion dynamics and cell migration" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]