Gerhard Multhaup, McGill University

Research

Alzheimer Disease Cerebral Amyloid Angiopathy Toxicity Abeta Aggregation Amyloid Clearance Human Cells And Tissues Seeding/Template Animal Models

Latest papers

Dually Charged Dendrimeric Polyglycerol Modulates Interleukin-33 at Alarmin Receptors in Microglia.
ACS chemical neuroscience · 2026
BACE-1 and ADAM-10 as Potential Peripheral Biomarkers for Alzheimer's Disease.
Current pharmaceutical design · 2026
Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway.
Proceedings of the National Academy of Sciences of the United States of America · 2025 · senior author

All 33 publications

Latest funding

Charging into the Future (CITF): Training in Polyelectrolyte Biosystems for Tomorrowès Health Challenges
NSERC · 2023 · Co-investigator
$508,892
Investigation of amyloid seeding in Cerebral Amyloid Angiopathy
CIHR · 2023 · Nominated PI
$50,000
Investigation of amyloid seeding in Cerebral Amyloid Angiopathy
CIHR · 2023 · Nominated PI
$1,061,056

All 9 grants and awards

33 publications.

01

Dually Charged Dendrimeric Polyglycerol Modulates Interleukin-33 at Alarmin Receptors in Microglia.

Zhang I, Herrmann A, Mohammadifar E, Herre F, Multhaup G, Haag R, Maysinger D

ACS chemical neuroscience2026

DOI: 10.1021/acschemneuro.6c00161 PMID: 42081615

02

BACE-1 and ADAM-10 as Potential Peripheral Biomarkers for Alzheimer's Disease.

Cervellati C, Trentini A, Zuin M, Mola G, Riccetti R, Manfrinato C, Sergi D, Multhaup G, Zuliani G

Current pharmaceutical design2026

DOI: 10.2174/0113816128339561241120135914 PMID: 39781737

03

Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway.

Ulku I, Ansari FE, Hancock MA, Zhou H, Cagnone G, Joyal JS, Fisher TAJ, Kennedy TE, Liebsch F, Multhaup G

Proceedings of the National Academy of Sciences of the United States of America2025Senior author

DOI: 10.1073/pnas.2507450122 PMID: 41144673

04

Serum β-secretase 1 (sBACE1) activity in subjective cognitive decline: an exploratory study.

Cervellati C, Trentini A, Rosta V, Passaro A, Brombo G, Renzini C, Multhaup G, Zuliani G

GeroScience2025

DOI: 10.1007/s11357-025-01523-x PMID: 39828771

05

Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression.

Ulku I, Leung R, Herre F, Walther L, Shobo A, Saftig P, Hancock MA, Liebsch F, Multhaup G

The Journal of biological chemistry2024Senior author

DOI: 10.1016/j.jbc.2024.107510 PMID: 38944120

06

Sulfated Hyperbranched and Linear Polyglycerols Modulate HMGB1 and Morphological Plasticity in Neural Cells.

Maysinger D, Zhang I, Wu PY, Kagelmacher M, Luo HD, Kizhakkedathu JN, Dernedde J, Ballauff M, Haag R, Shobo A, Multhaup G, McKinney RA

ACS chemical neuroscience2023

DOI: 10.1021/acschemneuro.2c00558 PMID: 36717083

07

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis.

Ulku I, Liebsch F, Akerman SC, Schulz JF, Kulic L, Hock C, Pietrzik C, Di Spiezio A, Thinakaran G, Saftig P, Multhaup G

Scientific reports2023Senior author

DOI: 10.1038/s41598-023-28846-z PMID: 36750595

08

Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease.

Gallwitz L, Schmidt L, Marques ARA, Tholey A, Cassidy L, Ulku I, Multhaup G, Di Spiezio A, Saftig P

Neurobiology of disease2022

DOI: 10.1016/j.nbd.2022.105919 PMID: 36347423

09

Biophysical characterization as a tool to predict amyloidogenic and toxic properties of amyloid-β42 peptides.

Shobo A, Röntgen A, Hancock MA, Multhaup G

FEBS letters2022Senior author

DOI: 10.1002/1873-3468.14358 PMID: 35466397

10

Insights into the Impact of Gold Nanoclusters Au10SG10 on Human Microglia.

Maysinger D, Sanader Maršić Ž, Gran ER, Shobo A, Macairan JR, Zhang I, Perić Bakulić M, Antoine R, Multhaup G, Bonačić-Kouteckỳ V

ACS chemical neuroscience2022

DOI: 10.1021/acschemneuro.1c00621 PMID: 35080850

Charging into the Future (CITF): Training in Polyelectrolyte Biosystems for Tomorrowès Health Challenges

Co-investigatorNSERC2023Collaborative Research and Training Experience

Principal investigators: Kizhakkedathu, Jayachandran N

Keywords: biomaterials; biomedical applications; drug delivery; material innovation for biology; nanomedicinie; polycations and polyanions; polyelectrolytes; protein binding; theoretical chemistry; therapeutics

$508,892