Gregory Fonseca, McGill University

Research

ATAC Cell death ChIP-sequencing DNA binding motif Machine learning macrophage Mass spectrometry NfkB

Latest papers

Machine-guided cell-fate engineering.
Cell reports · 2025
Induction of a memory-like CD4+ T-cell phenotype by airway smooth muscle cells.
European journal of immunology · 2024
Regulation of long non-coding RNA expression by aryl hydrocarbon receptor activation.
Toxicology letters · 2024

All 4 publications

Latest funding

The Sex Hormone Crossroad of Carotid Plaque Instability
CIHR · 2026 · Co-investigator
$589,050
Deciphering Host-Pathogen Interactions in Cystic Fibrosis Lung Through Spatial Transcriptomic Analysis
CIHR · 2024 · Supervisor
$210,000
Decoding how the aryl hydrocarbon receptor (AhR) controls cigarette smoke-induced lung inflammation and development of chronic obstructive pulmonary disease (COPD)
CIHR · 2023 · Co-investigator
$940,950

All 6 grants and awards

4 publications.

01

Machine-guided cell-fate engineering.

Appleton E, Tao J, Liu S, Glass C, Fonseca G, Church G

Cell reports2025

DOI: 10.1016/j.celrep.2025.115726 PMID: 40382774

02

Induction of a memory-like CD4+ T-cell phenotype by airway smooth muscle cells.

Jang JH, Zhou M, Makita K, Sun R, El-Hajjar M, Fonseca G, Lauzon AM, Martin JG

European journal of immunology2024

DOI: 10.1002/eji.202249800 PMID: 38334162

03

Regulation of long non-coding RNA expression by aryl hydrocarbon receptor activation.

Alluli A, Fonseca G, Matthews J, Eidelman DH, Baglole CJ

Toxicology letters2024

DOI: 10.1016/j.toxlet.2023.11.004 PMID: 38036013

04

DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal.

Cattaneo P, Hayes MGB, Baumgarten N, Hecker D, Peruzzo S, Aslan GS, Kunderfranco P, Larcher V, Zhang L, Contu R, Fonseca G, Spinozzi S, Chen J, Condorelli G, Dimmeler S, Schulz MH, Heinz S, Guimarães-Camboa N, Evans SM

Nature communications2022

DOI: 10.1038/s41467-022-35070-2 PMID: 36460641

The Sex Hormone Crossroad of Carotid Plaque Instability

Co-investigatorCIHR2026Project Grant

Principal investigators: Daskalopoulou, Stella S

Keywords: Atherosclerosis; Lcms; Maldi; Sex Differences; Sex Hormones; Spatial Proteomics; Spatial Transcriptomics

$589,050

Deciphering Host-Pathogen Interactions in Cystic Fibrosis Lung Through Spatial Transcriptomic Analysis

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Mathé, Justine

Keywords: Cystic Fibrosis; Microbiota; Pseudomonas Aeruginosa; Single-Cell Rna-Sequencing; Spatial Transcriptomics; Transcriptomic

$210,000

Decoding how the aryl hydrocarbon receptor (AhR) controls cigarette smoke-induced lung inflammation and development of chronic obstructive pulmonary disease (COPD)

Co-investigatorCIHR2023Project Grant

Principal investigators: Baglole, Carolyn

Keywords: Aryl Hydrocarbon Receptor; Chronic Obstructive Pulmonary Disease; Cigarette Smoke; Inflammation

$940,950

Studying transcription factor binding networks in activated and dying macrophages

Principal investigatorNSERC2022Discovery Launch Supplement

Principal investigators: Fonseca, Gregory

$12,500

Studying transcription factor binding networks in activated and dying macrophages

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Fonseca, Gregory

Keywords: transcription factor; dna binding motif; macrophage; nfkb; chip-sequencing; atac; rna-sequencing; mass spectrometry; machine learning; cell death

$84,000

Blood Epigenetic Age Biomarkers and Health Outcomes in COPD

Co-investigatorCIHR2022Project Grant - PA: Epigenetics/epigenomics in human health or disease

Principal investigators: Sin, Donald; Leung, Janice

Keywords: Ageing; Copd; Health Outcomes; Methylation

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Pharmacology and Toxicology

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Jason Matthews

Pharmacology and Toxicology

1 shared papers, latest 2024

Anne-Marie Lauzon

Medicine

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2022

Subject: Prospective PhD student: ATAC Dear Professor Fonseca, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Machine-guided cell-fate engineering." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Studying transcription factor binding networks in activated and dying macrophages" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]