James Martin, McGill University

Research

Cysteinyl Leukotrienes Macrophages Innate Lymphoid Cells Murine Model Anti-Fibrosis Cellular Therapy Fibrosis Fibrosis Resolution

Latest papers

Tissue-specific oxidative stress and bleomycin hydrolase signatures are associated with organ-specific fibrotic responses in a mouse model of systemic sclerosis.
Frontiers in cell and developmental biology · 2026
Equine Asthma: Current Understanding and Future Directions.
Frontiers in veterinary science · 2020
Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Allergy, Asthma & Clinical Immunology · 2019

All 9 publications

Latest funding

Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.
CIHR · 2024 · Principal investigator
$1,040,400
Understanding the Mechanistic Basis of Irritant-Induced Airway Dysfunction
CIHR · 2023 · Nominated PI
$562,275
Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats
CIHR · 2023 · Supervisor
$1,500

All 13 grants and awards

9 publications.

01

Tissue-specific oxidative stress and bleomycin hydrolase signatures are associated with organ-specific fibrotic responses in a mouse model of systemic sclerosis.

Johri R, Brizio M, Lora M, Joy S, Martin J, Colmegna I

Frontiers in cell and developmental biology2026

DOI: 10.3389/fcell.2026.1888823 PMID: 42682543

02

Equine Asthma: Current Understanding and Future Directions.

Couetil L, Cardwell JM, Leguillette R, Mazan M, Richard E, Bienzle D, Bullone M, Gerber V, Ivester K, Lavoie JP, Martin J, Moran G, Niedźwiedź A, Pusterla N, Swiderski C

Frontiers in veterinary science2020

DOI: 10.3389/fvets.2020.00450 PMID: 32903600

03

Omalizumab in patients with severe asthma and persistent sputum eosinophilia

Mukherjee M, Kjarsgaard M, Radford K, Huang C, Leigh R, Dorscheid DR, Lemiere C, Boulet L-P, Waserman S, Martin J

Allergy, Asthma & Clinical Immunology201921 citationsOpen Access

DOI: 10.1186/s13223-019-0337-2 PMID: W2944052075

04

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria J-P, O'Byrne PM, Gauvreau GM, Boulet L-P, Lemiere C, Martin J

Journal of Allergy and Clinical Immunology2016461 citations

DOI: 10.1016/j.jaci.2015.05.037

05

The Louis and Artur Lucian Award in Cardiovascular Diseases at McGill University.

Genest J, Hébert TE, Martin J

Circulation research2016Senior author

DOI: 10.1161/circresaha.116.309972 PMID: 27737939

06

Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle.

Chang NC, Nguyen M, Bourdon J, Risse PA, Martin J, Danialou G, Rizzuto R, Petrof BJ, Shore GC

Human molecular genetics2012

DOI: 10.1093/hmg/dds048 PMID: 22343142

07

Psychologic distress and maladaptive coping styles in patients with severe vs moderate asthma.

Lavoie KL, Bouthillier D, Bacon SL, Lemière C, Martin J, Hamid Q, Ludwig M, Olivenstein R, Ernst P

Chest2010

DOI: 10.1378/chest.09-1979 PMID: 20097803

08

Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction.

Kaminska M, Foley S, Maghni K, Storness-Bliss C, Coxson H, Ghezzo H, Lemière C, Olivenstein R, Ernst P, Hamid Q, Martin J

The Journal of allergy and clinical immunology2009Senior author

DOI: 10.1016/j.jaci.2009.03.049 PMID: 19481790

09

Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate.

Tulandi T, Martin J, Al-Fadhli R, Kabli N, Forman R, Hitkari J, Librach C, Greenblatt E, Casper RF

Fertility and sterility2006

DOI: 10.1016/j.fertnstert.2006.03.014 PMID: 16650422

Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.

Principal investigatorCIHR2024Project Grant

Principal investigators: Colmegna, Ines; Langlais, David; Martin, James G

Keywords: Anti-Fibrosis; Cellular Therapy; Fibrosis; Fibrosis Resolution; Lung Fibrosis; Multipotent Mesenchymal Stromal Cells; Scleroderma; Skin Fibrosis; Systemic Bleomycin Minipump Model

$1,040,400

Understanding the Mechanistic Basis of Irritant-Induced Airway Dysfunction

Nominated PICIHR2023Project Grant

Principal investigators: Martin, James G

Keywords: Airway Epithelium; Chlorine; Cysteinyl Leukotrienes; Innate Lymphoid Cells; Interleukin-13; Macrophages; Murine Model

$562,275

Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats

SupervisorCIHR2023CIHR-ICRH Travel Awards - General pool

Principal investigators: Sun, Rui

Keywords: Airway Inflammation; Allergy; Asthma; Sensitized Rats; Synthetic Double-Stranded Rna

$1,500

Determinants of susceptibility to influenza infection in pregnant mice

Nominated PICIHR2022Project Grant

Principal investigators: Martin, James G

Keywords: Allogeneic; Epithelium; Influenza A; Innate Lymphoid Cells; Interleukin 33; Macrophage; Murine Model; Syngeneic

$768,825

The role of eicosanoids in airway responses to oxidative injury from chlorine

Nominated PICIHR2017Project Grant

Principal investigators: Martin, James G

Keywords: Cysteinyl Leukotrienes; Fox P3; Induced Sputum; Inflammation; Knockout Mice; Macrophages; Occupational Asthma; Oxidative Injury; Prostaglandin E2; Spirometry

$707,625

Bidirectional crosstalk between T lymphocytes and airway smooth muscle

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Martin, James

$204,000

Asthmatic phenotyping by microfluidic assessment of shortening velocity and contractile force of airway smooth muscle cells obtained from biopsies

Co-investigatorCIHR2017Project Grant

Principal investigators: Lauzon, Anne-Marie

Keywords: Airway Hyperresponsiveness; Asthma; Biophysics; Cell; Contractile Force; Diagnostics; Microfluidics; Muscle Mechanics; Smooth Muscle; Velocity Of Shortening

$673,200

The EGFR; a key pathway in immune effector responses and asthmatic airway remodeling.

Nominated PICIHR2016Project Grant

Principal investigators: Martin, James G

Keywords: Airway Remodelling; Airway Smooth Muscle; Allergy; Asthma; Bronchoscopy; Epidermal Growth Factor Receptor; Sputum

$649,825

The role of CD44 in the bidirectional crosstalk between T lymphocytes and airway smooth muscle

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Martin, James

$130,000

Novel roles for cysteinyl leukotrienes in oxidant induced airway injury from chlorine

Nominated PICIHR2012Operating Grant

Principal investigators: Martin, James G

Keywords: 5-Lipoxygenase Pathway; Antioxidants; Asthma Model; Epithelial Repair

$624,809

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Rheumatology
Cardiology
Sciences cliniques
Respiratory Division

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Marta Kaminska

Respiratory Division

1 shared papers, latest 2009

Jean-Pierre Lavoie

Sciences cliniques

1 shared papers, latest 2020

Paul O'Byrne

Medicine

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Cysteinyl Leukotrienes Dear Professor Martin, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Tissue-specific oxidative stress and bleomycin hydrolase signatures are associated with organ-specific fibrotic responses in a mouse model of systemic sclerosis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells." (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

James Martin

Research

Latest papers

Latest funding

Tissue-specific oxidative stress and bleomycin hydrolase signatures are associated with organ-specific fibrotic responses in a mouse model of systemic sclerosis.

Equine Asthma: Current Understanding and Future Directions.

Omalizumab in patients with severe asthma and persistent sputum eosinophilia

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

The Louis and Artur Lucian Award in Cardiovascular Diseases at McGill University.

Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle.

Psychologic distress and maladaptive coping styles in patients with severe vs moderate asthma.

Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction.

Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate.

Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.

Understanding the Mechanistic Basis of Irritant-Induced Airway Dysfunction

Synthetic Double-stranded RNA Aggravates Allergen-induced Airway Inflammation and Remodelling While Suppressing the Expression of T Helper 2 Cytokines in the Sensitized Rats

Determinants of susceptibility to influenza infection in pregnant mice

The role of eicosanoids in airway responses to oxidative injury from chlorine

Bidirectional crosstalk between T lymphocytes and airway smooth muscle

Asthmatic phenotyping by microfluidic assessment of shortening velocity and contractile force of airway smooth muscle cells obtained from biopsies

The EGFR; a key pathway in immune effector responses and asthmatic airway remodeling.

The role of CD44 in the bidirectional crosstalk between T lymphocytes and airway smooth muscle

Novel roles for cysteinyl leukotrienes in oxidant induced airway injury from chlorine

Frequent collaborators

Parameswaran Krishna Nair

Melanie Kjarsgaard

Marta Kaminska

Jean-Pierre Lavoie

Richard Leigh

Jacques Genest

Gail Gauvreau

Roma Sehmi

Susan Waserman

Manali Mukherjee

John Paul Oliveria

Paul O'Byrne