Jun-Li Liu, McGill University

Research

Beta Cell Regeneration Cell Survival Gene-Targeting Insulin Secretion Molecular Mechanism Pancreatic Islets Proliferation Transgenic Mice

Latest papers

Chrononutrition in Gestational Diabetes: Toward Precision Timing in Maternal Care.
Journal of personalized medicine · 2025 · senior author
Endogenous expression of cellular communication network factor 5 on normal β-cells growth and insulin resistance caused by diet-induced obesity.
American journal of physiology. Endocrinology and metabolism · 2025 · senior author
A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.
Medical review (2021) · 2025 · senior author

All 45 publications

Latest funding

Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling
CIHR · 2020 · Nominated PI
$100,000
Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling
CIHR · 2020 · Nominated PI
$711,450
The role of CCN5 protein in maintaining normal growth of pancreatic islets
NSERC · 2017 · Principal investigator
$156,000

All 4 grants and awards

45 publications.

01

Chrononutrition in Gestational Diabetes: Toward Precision Timing in Maternal Care.

Xega V, Liu JL

Journal of personalized medicine2025Senior author

DOI: 10.3390/jpm15110534 PMID: 41295235

02

Endogenous expression of cellular communication network factor 5 on normal β-cells growth and insulin resistance caused by diet-induced obesity.

Xega V, Yang MH, Lopez N, Eskandari Shahraki M, Liu X, Kokoeva M, Lyons KM, Liu JL

American journal of physiology. Endocrinology and metabolism2025Senior author

DOI: 10.1152/ajpendo.00384.2024 PMID: 40983392

03

A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.

Farhat C, Xega V, Liu JL

Medical review (2021)2025Senior author

DOI: 10.1515/mr-2024-0039 PMID: 39974557

04

Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery.

Shi W, Xue H, Du T, Liu JL, Ling V, Wang Y, Ma Z, Gao ZH

Biomaterials science2024

DOI: 10.1039/d4bm00807c PMID: 39370988

05

Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health.

Xega V, Liu JL

Medical review (2021)2024Senior author

DOI: 10.1515/mr-2024-0012 PMID: 39135604

06

Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets.

Xega V, Alami T, Liu JL

Journal of cell communication and signaling2023Senior author

DOI: 10.1007/s12079-023-00765-8 PMID: 37245185

07

An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling.

Yang H, Messina-Pacheco J, Corredor ALG, Gregorieff A, Liu JL, Nehme A, Najafabadi HS, Riazalhosseini Y, Gao B, Gao ZH

Frontiers in immunology2022

DOI: 10.3389/fimmu.2022.961457 PMID: 35979350

08

Metabolic Effects of CCN5/WISP2 Gene Deficiency and Transgenic Overexpression in Mice.

Alami T, Liu JL

International journal of molecular sciences2021Senior author

DOI: 10.3390/ijms222413418 PMID: 34948212

09

REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.

Zhang H, Corredor ALG, Messina-Pacheco J, Li Q, Zogopoulos G, Kaddour N, Wang Y, Shi BY, Gregorieff A, Liu JL, Gao ZH

Communications biology2021

DOI: 10.1038/s42003-021-02193-z PMID: 34099862

10

Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic β-Cell Growth and Insulin Secretion.

Liu JL, Segovia I, Yuan XL, Gao ZH

International journal of molecular sciences2020First author

DOI: 10.3390/ijms21030910 PMID: 32019155

Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling

Nominated PICIHR2020Project Grant - PA: Nutrition, Metabolism and Diabetes

Principal investigators: Liu, Jun-Li

Keywords: Beta Cell Regeneration; Cell Survival; Celll Surface Receptor; Gene-Targeting; Human Islets; Insulin Secretion; Molecular Mechanism; Pancreatic Islets; Proliferation; Transgenic Mice

$100,000

Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling

Nominated PICIHR2020Project Grant

Principal investigators: Liu, Jun-Li

Keywords: Beta Cell Regeneration; Cell Surface Receptor; Cell Survival; Gene-Targeting; Insulin Secretion; Molecular Mechanism; Pancreatic Islets; Proliferation; Transgenic Mice

$711,450

The role of CCN5 protein in maintaining normal growth of pancreatic islets

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Liu, JunLi

$156,000

The role IGF-I in pancreatic iselt cell growth and glucose homeostasis

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Liu, JunLi

$109,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Nutritional Biochemistry
Human Genetics
Urologic Sciences
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Guang Ning

Nutritional Biochemistry

2 shared papers, latest 2014

Yuzhuo Wang

Urologic Sciences

1 shared papers, latest 2024

Yasser Riazalhosseini

Human Genetics

1 shared papers, latest 2022

Maia Kokoeva

Medicine

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Beta Cell Regeneration Dear Professor Liu, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Chrononutrition in Gestational Diabetes: Toward Precision Timing in Maternal Care." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jun-Li Liu

Research

Latest papers

Latest funding

Chrononutrition in Gestational Diabetes: Toward Precision Timing in Maternal Care.

Endogenous expression of cellular communication network factor 5 on normal β-cells growth and insulin resistance caused by diet-induced obesity.

A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.

Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery.

Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health.

Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets.

An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling.

Metabolic Effects of CCN5/WISP2 Gene Deficiency and Transgenic Overexpression in Mice.

REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.

Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic β-Cell Growth and Insulin Secretion.

Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling

Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling

The role of CCN5 protein in maintaining normal growth of pancreatic islets

The role IGF-I in pancreatic iselt cell growth and glucose homeostasis

Frequent collaborators

Guang Ning

Alex Gregorieff

Yuzhuo Wang

Victor Ling

Yasser Riazalhosseini

Maia Kokoeva

Jun-Li Liu

Research

Latest papers

Latest funding

Chrononutrition in Gestational Diabetes: Toward Precision Timing in Maternal Care.

Endogenous expression of cellular communication network factor 5 on normal &#x3b2;-cells growth and insulin resistance caused by diet-induced obesity.

A stepwise approach to deriving functional &#x3b2;-cells from human embryonic or induced pluripotent stem cells.

Penetration enhancers strengthen tough hydrogel bioadhesion and modulate locoregional drug delivery.

Beyond reproduction: unraveling the impact of sex hormones on cardiometabolic health.

Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets.

An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling.

Metabolic Effects of CCN5/WISP2 Gene Deficiency and Transgenic Overexpression in Mice.

REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.

Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic &#x3b2;-Cell Growth and Insulin Secretion.

Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling

Matricellular protein CCN5/WISP2 mediates a synergistic stimulation of pancreatic beta-cell expansion by IGF-I and Wnt signaling

The role of CCN5 protein in maintaining normal growth of pancreatic islets

The role IGF-I in pancreatic iselt cell growth and glucose homeostasis

Frequent collaborators

Guang Ning

Alex Gregorieff

Yuzhuo Wang

Victor Ling

Yasser Riazalhosseini

Maia Kokoeva

Endogenous expression of cellular communication network factor 5 on normal β-cells growth and insulin resistance caused by diet-induced obesity.

A stepwise approach to deriving functional β-cells from human embryonic or induced pluripotent stem cells.

Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic β-Cell Growth and Insulin Secretion.