Kalle Gehring, McGill University

Research

Mitochondria X-Ray Crystallography Structural Biology Neurodegeneration Autophagy Ubiquitin Crc Nmr Spectroscopy

Latest papers

The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models.
iScience · 2026
The divergent LARP1 PAM2 motif adopts a non-canonical conformation for MLLE binding.
Biochemical and biophysical research communications · 2026 · senior author
The cytoplasmic domains of the CNNM family of transmembrane proteins modulate the ion channel-kinase TRPM7.
The Journal of biological chemistry · 2025

All 126 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2025 · Nominated PI
$1,400,000
Development of Small Molecule Activators of Parkin, a Neuroprotective Ubiquitin Ligase
CIHR · 2025 · Nominated PI
$1,396,125
Structure and Function of Bacterial CNNM Magnesium Transporters
NSERC · 2020 · Principal investigator
$226,125

All 27 grants and awards

126 publications.

01

The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models.

Jolly JT, Felisbino K, Mahbub L, Al-Hamaly MA, Jin M, Smith CN, Kozlov G, Gehring K, Blackburn JS

iScience2026

DOI: 10.1016/j.isci.2026.117338 PMID: 42699321

02

The divergent LARP1 PAM2 motif adopts a non-canonical conformation for MLLE binding.

Behvarmanesh A, Kozlov G, Sprules T, Gehring K

Biochemical and biophysical research communications2026Senior author

DOI: 10.1016/j.bbrc.2026.153517 PMID: 41762867

03

The cytoplasmic domains of the CNNM family of transmembrane proteins modulate the ion channel-kinase TRPM7.

Tetteh S, Zong P, Feng J, Lee EL, Al-Saadi N, Willekens J, Shah A, Nethramangalath T, Galeano AL, Zheng H, Gehring K, Yue L, Runnels LW

The Journal of biological chemistry2025

DOI: 10.1016/j.jbc.2025.110720 PMID: 40962059

04

Deep Mutational Scanning of an Engineered High-affinity Ligand of the poly(A) Binding Protein MLLE Domain.

Behvarmanesh A, Kozlov G, Wagner JP, Chen YS, Gehring K

Journal of molecular biology2025Senior author

DOI: 10.1016/j.jmb.2025.169120 PMID: 40180125

05

Structure of the phosphocysteine intermediate of the phosphatase of regenerating liver PTP4A1.

Mahbub L, Kozlov G, Knorn C, Gehring K

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2025.110251 PMID: 40398601

06

A molecular glue for PRKN/parkin.

Sauvé V, Gehring K

Autophagy2025Senior author

DOI: 10.1080/15548627.2024.2443232 PMID: 39699041

07

Structural basis for the pathogenicity of parkin catalytic domain mutants.

Wagner JP, Sauvé V, Saran A, Gehring K

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2024.108051 PMID: 39631693

08

Activation of parkin by a molecular glue.

Sauvé V, Stefan E, Croteau N, Goiran T, Fakih R, Bansal N, Hadzipasic A, Fang J, Murugan P, Chen S, Fon EA, Hirst WD, Silvian LF, Trempe JF, Gehring K

Nature communications2024Senior author

DOI: 10.1038/s41467-024-51889-3 PMID: 39300082

09

Naturally occurring hyperactive variants of human parkin.

Huq TS, Luo J, Fakih R, Sauvé V, Gehring K

Communications biology2024Senior author

DOI: 10.1038/s42003-024-06656-x PMID: 39117722

10

Dimerization of the CNNM extracellular domain.

Shahsavan A, Lee EL, Illes K, Kozlov G, Gehring K

Protein science : a publication of the Protein Society2024Senior author

DOI: 10.1002/pro.4860 PMID: 38149326

Canada Research Chair - Tier 1

Nominated PICIHR2025Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Gehring, Kalle B

Keywords: Crc

$1,400,000

Development of Small Molecule Activators of Parkin, a Neuroprotective Ubiquitin Ligase

Nominated PICIHR2025Project Grant

Principal investigators: Gehring, Kalle B

Keywords: Autophagy; Dna-Encoded Library; Drug Discovery; Mitochondria; Molecular Glue; Neuroscience; Parkinson'S Disease; Protein Phosphorylation; Structural Biology; Ubiquitin

$1,396,125

Structure and Function of Bacterial CNNM Magnesium Transporters

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Gehring, Kalle

$226,125

Canada Research Chair Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Gehring, Kalle B

Keywords: Crc

$1,400,000

Studies of the PRL/CNNM pathway in metastatic cancer

SupervisorCIHR2018Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Chen, Yu

Keywords: Biophysics; Cancer; Cryo-Electron Microscopy; Cyclin M (Cnnm); Drug Discovery; Integral Membrane Protein; Magnesium Transporter; Phosphatase Of Regenerating Liver (Prl); Structural Biology; X-Ray Crystallography

$105,000

Structural studies of neurodegenerative diseases

Nominated PICIHR2017Foundation Grant

Principal investigators: Gehring, Kalle B

Keywords: Mitochondria; Neurodegeneration; Nmr Spectroscopy; Protein Aggregation; Structural Biology; Ubiquitin; Ubiquitin Proteasome System; X-Ray Crystallography

$2,800,246

Structural studies of Parkinson's disease

Nominated PICIHR2017Project Grant

Principal investigators: Gehring, Kalle B

Keywords: Chaperone; Mitochondria; Neurodegeneration; Nmr Spectroscopy; Structural Biology; Ubiquitin Proteasome System; X-Ray Crystallography

$1,208,700

Structural and functional exploration of the misfolded protein sensor, UGGT

SupervisorCIHR2016CIHR Fellowship

Principal investigators: Yang, Meng

Keywords: 3d-Structure; Cryo-Electron Microscopy; Endoplasmic Reticulum; Glucosylation; Glycoprotein; Misfolded Proteins; Protein Chaperone; Protein Folding Diseases; Quality Sensor; Uggt

$135,000

Robot for lipidic cubic phase (LCP) crystallization of membrane proteins

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Baron, Christian

$143,943

Protein folding in the endoplasmic reticulum

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Gehring, Kalle

$265,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry
Neurology and Neurosurgery
Oncology
Pédiatrie
Chemical Engineering
Mechanical Engineering
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Bernard Brais

Neurology and Neurosurgery

6 shared papers, latest 2019

Qian Liu

Faculty

4 shared papers, latest 2010

Morag Park

Oncology

3 shared papers, latest 2007

Bhushan Nagar

Biochemistry

2 shared papers, latest 2013

Nahum Sonenberg

Biochemistry

2 shared papers, latest 2008

Andrea Richter

Pédiatrie

1 shared papers, latest 2012

Gregory De Crescenzo

Mechanical Engineering

1 shared papers, latest 2006

Gregory De Crescenzo

Chemical Engineering

1 shared papers, latest 2006

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Mitochondria Dear Professor Gehring, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The CNNM-binding interface drives PRL-3-dependent tumor progression in de novo cancer models." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chair - Tier 1" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]