Faculty profile

Nahum Sonenberg

ResearcherBiochemistryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Nahum Sonenberg

Researcher

Biochemistry

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
67 publications in the last five years, latest in 2026.
Senior (last) author on 26 recent papers, a sign of leading a research group.
Principal investigator on 23 research grants (22 CIHR, 1 NSERC), most recently in 2025.
Supervised 16 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

295

Publications

105

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Mrna Translation Microrna Protein Synthesis Autism Spectrum Disorder Translational Control Autism Ribosome Profiling Behavior

Latest papers

Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution.
Nature cell biology · 2026
Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins.
Cell reports · 2026
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.
eLife · 2026

All 295 publications

Latest funding

Unlocking Psilocybin's Antidepressant Mechanisms: Receptor Targets, Neuronal Circuits, and m-TOR Plasticity
CIHR · 2025 · Co-investigator
$684,675
mRNA Translational Repression by GIGYF Proteins and Their Partners
CIHR · 2025 · Nominated PI
$1,053,406
Deciphering the role of 4E-T in enterovirus infection
CIHR · 2025 · Supervisor
$120,000

All 48 grants and awards

From the 150 most recent of 295 publications.

Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution.

Diao S, Zou JY, Wang S, Chan JE, Kortlever RM, Poulain N, Ghaddar N, Kim H, Evan GI, Koumenis C, Hatzoglou M, Walter P, Sonenberg N, Le Quesne J, Tammela T, Koromilas AE

Nature cell biology2026

DOI: 10.1038/s41556-026-01991-z PMID: 42298057

Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins.

Harris Snell P, Naeli P, Garzia A, Chen Y, Waldron JA, Chatterjee S, McGirr T, Kilmartin A, Mohammad Almomani ES, Kelsall IR, Ladak RJ, Choi JH, Luo J, Leino SA, Jess N, Shariati SA, Soto X, Gkogkas CG, Sonenberg N, Tuschl T, Maguire S, Jafarnejad SM

Cell reports2026

DOI: 10.1016/j.celrep.2026.117511 PMID: 42268714

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.

Lister KC, Wong C, Uttam S, Parisien M, Stecum P, Brown N, Cai W, Ho-Tieng D, Hooshmandi M, Gu N, Amiri M, Beaudry F, Jafarnejad SM, Tavares-Ferreira D, Inturi NN, Mazhar K, Zhao HT, Fitzsimmons B, Gkogkas CG, Sonenberg N, Price TJ, Diatchenko L, Atlasi Y, Mogil JS, Khoutorsky A

eLife2026

DOI: 10.7554/elife.100451 PMID: 41960785

4E-BP inhibition ameliorates heart failure through translational upregulation of SERCA2a and modulation of mitochondrial redox signaling in cardiomyocytes.

Gao J, Lan T, Xu X, Guo H, Wang S, Zhang P, Polunovsky VA, Sonenberg N, Bitterman PB, Bache RJ, Hu X, Lu Z, Chen Y

Redox biology2026

DOI: 10.1016/j.redox.2026.104089 PMID: 41713223

The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior.

Mahmood N, Dang CL, Wu PY, Huang Z, Choi JH, Psycharis K, Portugese R, Khoutorsky A, Costa-Mattioli M, McKinney RA, Sonenberg N

Proceedings of the National Academy of Sciences of the United States of America2026Senior author

DOI: 10.1073/pnas.2532796123 PMID: 41706892

4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory.

Huang Z, Mahmood N, Psycharis K, Lister K, Hooshmandi M, Nageshwar Inturi N, Tavares-Ferreira D, Wiebe S, Khoutorsky A, Sonenberg N

Molecular neurobiology2026Senior author

DOI: 10.1007/s12035-026-05684-4 PMID: 41615594

Viral inhibition of the anaphase promoting complex enhances replication by elevating nucleotide pools.

Chen OJ, Feng CY, Blanchette P, Ladak RJ, Crosby MA, de Sá Tavares Russo M, Wang Y, Fernandez C, Liang Y, Sharon DM, Moustafa-Kamal M, Gamache I, Sonenberg N, Avizonis D, Teodoro JG

PLoS pathogens2026

DOI: 10.1371/journal.ppat.1013930 PMID: 42585267

FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall.

Li JT, Amiri M, Kailasam S, Drever L, Sun J, Bohorquez L, Sonenberg N, Ortega J, Sossin WS

eLife2026

DOI: 10.7554/elife.106692 PMID: 42474467

Uncovering novel endocannabinoidome-gut microbiome-brain axis-based therapeutic targets in a Fragile X Syndrome mouse model.

Campanale A, Mir HD, Dumais E, Inserra A, Flamand N, Chakravarty M, Gantois I, Siddiqui N, Sonenberg N, Gobbi G, Silvestri C, Di Marzo V

Progress in neuro-psychopharmacology & biological psychiatry2026

DOI: 10.1016/j.pnpbp.2025.111575 PMID: 41386393

Shank3B-/- pathophysiology: Early metformin treatment rescues behavioural deficits and normalises exacerbated mRNA translation.

Marsal-García L, Choi JH, Peraldi E, Wu PY, Dang CL, McKinney RA, Gantois I, Sonenberg N

Neurobiology of disease2026Senior author

DOI: 10.1016/j.nbd.2025.107217 PMID: 41352540

Unlocking Psilocybin's Antidepressant Mechanisms: Receptor Targets, Neuronal Circuits, and m-TOR Plasticity

Co-investigatorCIHR2025Project Grant

Principal investigators: Gobbi, Gabriella

Keywords: Antidepressant; Behavioral Pharmacology; Electrophysiology; M-Tor; Molecular Biology; Psilocybin; Psychedelics; Rapid Antidepressant

$684,675

mRNA Translational Repression by GIGYF Proteins and Their Partners

Nominated PICIHR2025Project Grant

Principal investigators: Sonenberg, Nahum

Keywords: 4ehp; Gigyf1/2; Microrna; Mrna Translation; Ribosome Profiling

$1,053,406

Deciphering the role of 4E-T in enterovirus infection

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Bellucci, Michael

Keywords: Innate Immunity; Mrna Metabolism; Mrna Translation; Non-Polio Enteroviruses; Phosphorylation; Protein-Protein Interactions; Ribosome Profiling; Slam-Seq

$120,000

A histology platform to visualize cells, tissues and organs across living systems

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Cockburn, Katherine

Keywords: Animal models; Biomedical engineering; Cell biology; Cell morphology; Gene expression; Histology; Materials science; Tissue architecture; Tissue sectioning

$97,880

Dysregulated insulin signaling in the pathophysiology of ASD

Nominated PICIHR2024Project Grant

Principal investigators: Sonenberg, Nahum

Keywords: Autism Spectrum Disorder; Behavior; Fragile X Syndrome; Insulin Receptor; Mouse Model; Protein Synthesis

$1,101,600

21st Workshop Fragile X syndrome & other Neurodevelopmental Disorders

Nominated PICIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Sonenberg, Nahum

Keywords: Autism Spectrum Disorder; Cognitive Disorders; Conference; Fragile X; Genetic Disease; Intellectual Disability; Neurodevelopmental Disorders; Workshop

$10,000

Leveraging the immunosuppressive function of SARS-CoV-2-encoding NSP2 to improve VSVd51 oncolytic efficacy

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Ladak, Reese

Keywords: 4ehp; Immunotherapy; Interferon-Beta; Nsp2; Oncolytic Viruses; Riboseq; Translation Repression; Tumour Mouse Models; Vsvd51

$105,000

Control of Host mRNA Translation in Enterovirus Infection

Nominated PICIHR2023Project Grant

Principal investigators: Sonenberg, Nahum

Keywords: Crispr Screen; Functional Genomics; Mrna Translation; Ribosome Profiling; Single-Molecule Imaging Assays; Viral Infection

$1,093,645

Regulation of long-term memory via eIF2alpha-dependent translational control mechanisms

Nominated PICIHR2022Project Grant

Principal investigators: Sonenberg, Nahum

Keywords: Astrocytes; Eif2a; Gcn2; Impact; Memory; Synaptic Plasticity

$1,109,250

Role and regulatory mechanisms of pre- versus post-synaptic mRNA translation in remote memory recall at single neuron type resolution 'in vivo'

SupervisorCIHR2022CIHR Fellowship

Principal investigators: Cagnetta, Roberta

Keywords: Adeno-Associated Virus-Based Gene Targeting 'In Vivo'; Local Mrna Translation; Memory Reconsolidation; Neural Circuit Maintenance And Remodelling; Parvalbumin-Expressing Interneurons; Pre- And Post-Synaptic Terminals; Remote Memory Recall; Ribosome Profiling; Synaptic Plasticity; Translational Control

$45,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Nahum Sonenberg

Research

Latest papers

Latest funding

Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution.

Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins.

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.

4E-BP inhibition ameliorates heart failure through translational upregulation of SERCA2a and modulation of mitochondrial redox signaling in cardiomyocytes.

The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior.

4E-BP2-dependent translational control in GABAergic interneurons is required for long-term memory.

Viral inhibition of the anaphase promoting complex enhances replication by elevating nucleotide pools.

FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall.

Uncovering novel endocannabinoidome-gut microbiome-brain axis-based therapeutic targets in a Fragile X Syndrome mouse model.

Shank3B-/- pathophysiology: Early metformin treatment rescues behavioural deficits and normalises exacerbated mRNA translation.

A histology platform to visualize cells, tissues and organs across living systems

Frequent collaborators

Arkady Khoutorsky

Ivan Topisirovic

Jerry Pelletier

Ivan Topisirovic

Tommy Alain

Jean-Claude Lacaille

Karim Nader

Bhushan Nagar

Masha Prager-Khoutorsky

Michael Pollak

Argel Aguilar Valles

Anne-Claude Gingras

Gabriella Gobbi

Shimon Amir

Shimon Amir

Argel Aguilar Valles

Morag Park

Arnim Pause

Yojiro Yamanaka

Alfredo Ribeiro-Da-Silva

Thomas Duchaine

Morag Park

Kalle Gehring

Karen Mossman

Jean-Simon Diallo

Martin Olivier

Robert Rottapel

Yonghong Wan

Brian Lichty

Ali A Ashkar