Lawrence Kleiman, McGill University

Research

Apobec3g Conformation Of Hiv-1 Genomic Rna (Shape)Conformation Of Hiv-1 Trnalys3 (Shape)Hiv-1 Gag Hiv-1 Genomic Rna Dimerization Hiv-1 Infectivity Hiv-1 Replication Primer Trnalys3 Annealing To Hiv-1 Grna

Latest papers

Export of Precursor tRNAIle from the Nucleus to the Cytoplasm in Human Cells.
PloS one · 2016 · senior author
Inhibition of HIV-1 assembly by coiled-coil domain containing protein 8 in human cells.
Scientific reports · 2015 · senior author
In virio SHAPE analysis of tRNA(Lys3) annealing to HIV-1 genomic RNA in wild type and protease-deficient virus.
Retrovirology · 2015 · senior author

All 28 publications

Latest funding

Regulation of primer tRNALys3 annealing to HIV-1 genomic RNA during HIV-1 replication.
CIHR · 2014 · Nominated PI
$100,000
Annealing of primer tRNALys3 to genomic RNA in HIV-1
CIHR · 2011 · Nominated PI
$86,336
Formation of the tRNALys packaging complex in HIV-1
CIHR · 2009 · Nominated PI
$741,370

All 4 grants and awards

28 publications.

01

Export of Precursor tRNAIle from the Nucleus to the Cytoplasm in Human Cells.

Wei M, Zhao X, Liu M, Niu M, Seif E, Kleiman L

PloS one2016Senior author

DOI: 10.1371/journal.pone.0154044 PMID: 27101286

02

Inhibition of HIV-1 assembly by coiled-coil domain containing protein 8 in human cells.

Wei M, Zhao X, Liu M, Huang Z, Xiao Y, Niu M, Shao Y, Kleiman L

Scientific reports2015Senior author

DOI: 10.1038/srep14724 PMID: 26423533

03

In virio SHAPE analysis of tRNA(Lys3) annealing to HIV-1 genomic RNA in wild type and protease-deficient virus.

Seif E, Niu M, Kleiman L

Retrovirology2015Senior author

DOI: 10.1186/s12977-015-0171-7 PMID: 25981241

04

Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA.

Xing L, Niu M, Kleiman L

Biochimica et biophysica acta2014Senior author

DOI: 10.1016/j.bbagrm.2014.08.008 PMID: 25149208

05

Human APOBEC3F incorporation into human immunodeficiency virus type 1 particles.

Wang X, Li X, Ma J, Zhang L, Ma L, Mi Z, Zhou J, Guo F, Kleiman L, Cen S

Virus research2014

DOI: 10.1016/j.virusres.2014.07.011 PMID: 25038404

06

Helicase associated 2 domain is essential for helicase activity of RNA helicase A.

Xing L, Zhao X, Niu M, Kleiman L

Biochimica et biophysica acta2014Senior author

DOI: 10.1016/j.bbapap.2014.07.001 PMID: 25062910

07

The role of A-kinase anchoring protein 95-like protein in annealing of tRNALys3 to HIV-1 RNA.

Xing L, Zhao X, Guo F, Kleiman L

Retrovirology2014Senior author

DOI: 10.1186/1742-4690-11-58 PMID: 25034436

08

Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing.

Koh HR, Xing L, Kleiman L, Myong S

Nucleic acids research2014

DOI: 10.1093/nar/gku523 PMID: 24914047

09

Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell.

Xing L, Niu M, Zhao X, Kleiman L

Biochimica et biophysica acta2014Senior author

DOI: 10.1016/j.bbagen.2014.04.003 PMID: 24726449

10

Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism.

Xing L, Niu M, Zhao X, Kleiman L

PloS one2013Senior author

DOI: 10.1371/journal.pone.0078596 PMID: 24223160

Regulation of primer tRNALys3 annealing to HIV-1 genomic RNA during HIV-1 replication.

Nominated PICIHR2014Operating Grant - PA: HIV/AIDS Bridge Funding - Biomedical/Clinical Stream

Principal investigators: Kleiman, Lawrence

Keywords: Apobec3g; Conformation Of Hiv-1 Genomic Rna (Shape); Conformation Of Hiv-1 Trnalys3 (Shape); Hiv-1 Gag; Hiv-1 Genomic Rna Dimerization; Hiv-1 Infectivity; Hiv-1 Replication; Primer Trnalys3 Annealing To Hiv-1 Grna; Reverse Transcription; Rna Helicase A

$100,000

Annealing of primer tRNALys3 to genomic RNA in HIV-1

Nominated PICIHR2011Operating Grant - PA: HIV/AIDS Bridge Funding - Biomedical/Clinical Stream

Principal investigators: Kleiman, Lawrence

Keywords: Gag; Hiv-1; Pbsncrna; Primer Trnalys3 Annealing; Reverse Transcription; Rna Helicase A; Sirna; Viral Genomic Rna

$86,336

Formation of the tRNALys packaging complex in HIV-1

Nominated PICIHR2009Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Kleiman, Lawrence

Keywords: Gag; Gagpol; Genomic Rna; Hiv-1 Assembly; Lysyl-Trna; Primer Trnalys3 For Reverse Transcription

$741,370

Development of New Strategies to Target HIV Replication and Stimulate anti-HIV Post-Exposure Immunity

Co-investigatorCIHR2009Team Grant: China-Canada Collaborative Teams in Health Research

Principal investigators: Wainberg, Mark A

Keywords: Hiv/Aids; Inhibitors; Innate Immunity; Latency; Vaccine

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Lady Davis Institute for Medical Research
AIDS Pathogenesis Unit
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Shan Cen

Faculty

9 shared papers, latest 2009

Chen Liang

AIDS Pathogenesis Unit

2 shared papers, latest 2011

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Subject: Prospective PhD student: Apobec3g Dear Professor Kleiman, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Export of Precursor tRNAIle from the Nucleus to the Cytoplasm in Human Cells." (2016), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]