Faculty profile

Nick Daneman

ResearcherInfectious Diseases/Internal MedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Nick Daneman

Researcher

Infectious Diseases/Internal Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
165 publications in the last five years, latest in 2026.
Senior (last) author on 51 recent papers, a sign of leading a research group.
Principal investigator on 30 research grants (30 CIHR), most recently in 2026.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

320

Publications

6,498

Citations

259

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Randomized Controlled Trial Antimicrobial Resistance Antibiotic Treatment Duration Of Therapy Adaptive Platform Trial Antibiotic De-Escalation Bloodstream Infection Central Venous Catheter Infection

Latest papers

Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia
New England Journal of Medicine · 2026
Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection
JAMA Network Open · 2026
Shorter versus longer durations of antibiotic treatment for pneumonia in dogs and cats: a systematic review and meta-analysis.
Journal of the American Veterinary Medical Association · 2026 · senior author

All 320 publications

Latest funding

Evaluating De-escalation Strategies for Gram-Negative Sepsis
CIHR · 2026 · Supervisor
$120,000
Treatment of Enterococcal Bacteremia Platform (TENT)
CIHR · 2026 · Principal investigator
$1,946,926
Canadian ANtibiotic prescribing feedback initiative: Building a national framework to combat AntiMicrobial Resistance in primary care (CANBuild-AMR) - Planning and Dissemination Grant
CIHR · 2025 · Co-investigator
$50,000

All 68 grants and awards

From the 150 most recent of 320 publications.

Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia

Lee TC, Barina LA, Walls G, Goodman AL, Yahav D, Cheng MP, Bonten M, Bowen AC, Boyles T, Daneman N

New England Journal of Medicine202613 citations

DOI: 10.1056/nejmoa2506905

Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection

McDonald EG, Butler-Laporte G, Brophy JM, Elsayed S, Frenette C, Huseen I, Loo VG, Moran K, Coburn B, Hota SS

JAMA Network Open20268 citations

DOI: 10.1001/jamanetworkopen.2025.60495

Shorter versus longer durations of antibiotic treatment for pneumonia in dogs and cats: a systematic review and meta-analysis.

Emdin F, Emdin A, Ong SWX, Leung V, Schwartz KL, Langford BJ, Brown KA, Weese JS, Massarella S, Daneman N

Journal of the American Veterinary Medical Association20263 citationsSenior author

DOI: 10.2460/javma.25.09.0588

Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study

Brown KA, Coburn B, Hernandez A, Langford BJ, Leung V, MacFadden D, Rooney AM, Schwartz KL, Daneman N

Journal of Infectious Diseases20263 citationsSenior author

DOI: 10.1093/infdis/jiag001

Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial

Ong SWX, Pinto R, Mahar RK, Rishu A, Davis JS, Fowler RA, Tong SYC, Daneman N, consortium BT, Rogers B

The Lancet Infectious Diseases20263 citationsSenior author

DOI: 10.1016/s1473-3099(25)00592-4

Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections

Ramendra R, Wright JK, Kain KC, Kim B, Mishra H, Zhong K, Aslanian P, Carignan A, Conly J, Detsky M

JAMA Network Open20262 citationsSenior author

DOI: 10.1001/jamanetworkopen.2026.20973

Comparing different methods for analysing hierarchical composite endpoints: two illustrative case studies with post hoc analyses of the BALANCE (Bacteraemia Antibiotic Length Actually Needed for Clinical Effectiveness) and CAMERA2 (Combination Antibiotics for methicillin-resistant Staphylococcus aureus) randomized clinical trials

Ong SWX, Pinto R, Mahar RK, Petersiel N, Fowler RA, Davis JS, Daneman N, Tong SYC, Lye DC, Yahav D

Clinical Microbiology and Infection (CMI)20262 citations

DOI: 10.1016/j.cmi.2025.11.027

Variability in Hospital-Onset Bacteremia in Ontario.

Bedard-Lapointe O, Wei XS, Daneman N, Brown K, Manzoor F, Golmohammadzadeh M, Mertz D, Chagla Z, Flemming JA, Gill SS

JAMA Network Open20261 citations

DOI: 10.1001/jamanetworkopen.2026.32981

Antimicrobial stewardship resourcing and programme outcomes: a scoping review

Langford BJ, Kang AY, Ji M, Bhatjire P, Huynh K, Lim S, McArthur A, Brown K, Daneman N, Schwartz KL

JAC-Antimicrobial Resistance20261 citations

DOI: 10.1093/jacamr/dlag034

Duration of Therapy for Pseudomonas aeruginosa Bacteremia—A Post Hoc Subgroup Analysis From the BALANCE Randomized Controlled Trial

Yahav D, Pinto R, Cook D, Davis J, Duan E, Hoffman T, Lee TC, McDonald EG, Morpeth S, Muscedere J

Clinical Infectious Diseases20261 citationsSenior author

DOI: 10.1093/cid/ciag144

Evaluating De-escalation Strategies for Gram-Negative Sepsis

SupervisorCIHR2026DRA: Canada Impact+ Research Training Awards - Doctoral

Principal investigators: Yisa, Mohammed

Keywords: Antimicrobial Stewardship; Blood Stream Infections; Gram-Negative; Treatment Outcomes

$120,000

Treatment of Enterococcal Bacteremia Platform (TENT)

Principal investigatorCIHR2026Project Grant

Principal investigators: Lee, Todd C; Briggs, Simon; Cheng, Matthew P; Daneman, Nick; Davis, Joshua; Golchi, Shirin; Goodman, Anna L; Hasse, Barbara; Kuehl, Richard; Martin, Yonas; McDonald, Emily G; Mertz, Dominik; Paul, Mical; Sligl, Wendy I; Somayaji, Ranjani; Speich, Benjamin; Tong, Steven; Walls, Genevieve

Keywords: Bacteremia; Bloodstream Infection; Endocarditis; Enterococcus; Platform Trial; Randomized Controlled Trial

$1,946,926

Canadian ANtibiotic prescribing feedback initiative: Building a national framework to combat AntiMicrobial Resistance in primary care (CANBuild-AMR) - Planning and Dissemination Grant

Co-investigatorCIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Schwartz, Kevin L

Keywords: Antimicrobial Resistance; Antimicrobial Stewardship; Audit And Feedback; Knowledge Translation; Primary Care

$50,000

Oral Vancomycin for the Prevention of C. difficile Infection in High-Risk HCT and CAR-T Patients (VAPOR-HCT): A Pilot Randomized Placebo-Controlled Trial

Principal investigatorCIHR2025Project Grant - Priority Announcement - Cancer Survivorship

Principal investigators: MacFadden, Derek R; Atkins, Harold L; Buchan, Catharine A; Cheng, Matthew P; Climans, Troy; Coburn, Bryan A; Daneman, Nick; Gauthier, Karine; Hay, Annette; Kabbani, Dima; Kekre, Natasha; Kennah, Michael; McIntyre, Lauralyn A; Mertz, Dominik; Monteith, Bethany E; Mortimer, Leanne M; Purssell, Andrew; Taljaard, Monica; Tsang, Corey

Keywords: Antimicrobial Resistance; Biomarker; C.Difficile Infection; Chimeric Antigen Receptor T-Cell Therapy; Feasibility; Hematopoietic Stem Cell Transplantation; Microbiome; Pilot; Prophylaxis; Randomized Trial

$100,000

Strategies for the Treatment and Prevention of Recurrent Clostridioides difficile infection: The SPORES Platform

Principal investigatorCIHR2025Project Grant

Principal investigators: McDonald, Emily G; Carignan, Alex; Chan, Adrienne; Chen, Yan; Daley, Peter; Daneman, Nick; Kandel, Christopher; Lee, Todd C; Longtin, Yves; Perez Patrigeon, Santiago; Wuerz, Terence

Keywords: C. Difficile; Clostridioides Difficile Infection; Diarrhea; Fidaxomicin; Nosocomial Infection; Placebo Controlled; Platform Trial; Randomized Controlled Trial; Recurrence; Vancomycin

$2,015,775

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Nominated PICIHR2025Project Grant

Principal investigators: Daneman, Nick; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Ong, Sean W; Pinto, Ruxandra; Rogers, Benjamin A

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Duration; Antibiotic Oral Switch; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Clinical Trial

$1,908,674

Practical Antibiograms for Long-Term Care: From Small-Sample Methods to Facility Targets and Individualized Risk

SupervisorCIHR2025Doctoral Research Award: PA -General Pandemic Prepared./Health Emergen. Research

Principal investigators: Amer, Adan

Keywords: Antimicrobial Resistance; Long-Term Care; Precision Medicine; Predictive Modelling; Urinary Tract Infections

$120,000

Clopidogrel vs. Aspirin in S. aureus Bacteremia (Clopido-SNAP)

Principal investigatorCIHR2024Project Grant

Principal investigators: Lee, Todd C; Cheng, Matthew P; Daneman, Nick; Davis, Joshua; Goodman, Anna L; Lawler, Patrick R; McDonald, Emily G; Mertz, Dominik; Paul, Mical; Siegal, Deborah M; Tong, Steven; Walls, Genevieve

Keywords: Antithrombotic Therapy; Bacteremia; Randomized Controlled Trial; Staphylococcus Aureus

$539,325

Vancomycin dosing for serious MRSA infections: A non-inferiority randomized trial of trough level versus AUC/MIC.

Principal investigatorCIHR2024Project Grant

Principal investigators: Bai, Anthony D; Daneman, Nick; Jorgensen, Sarah C; Lee, Todd C; Loeb, Mark B; McDonald, Emily G; Mertz, Dominik; Morris, Andrew M

Keywords: Antibiotic Resistance; Antibiotic Therapy; Methicillin-Susceptible Staphylococcus Aureus (Mrsa); Vancomycin

$749,700

BALANCE+ PRO (Patient-informed Relevant Outcomes)

Co-investigatorCIHR2024Project Grant

Principal investigators: Somayaji, Ranjani; Fiest, Kirsten M; Fowler, Robert A

Keywords: Balance+ Trial; Blood Stream Infections; Critical Illness; Health Outcomes; International Study; Mixed-Methods Study; Patient Informed Outcomes; Patients And Family Members; Quality Of Life; Severe Infections

$309,825

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Nick Daneman

Research

Latest papers

Latest funding

Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia

Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection

Shorter versus longer durations of antibiotic treatment for pneumonia in dogs and cats: a systematic review and meta-analysis.

Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study

Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial

Procalcitonin to Guide 7 vs 14 Days of Antibiotics in Bloodstream Infections

Variability in Hospital-Onset Bacteremia in Ontario.

Antimicrobial stewardship resourcing and programme outcomes: a scoping review

Duration of Therapy for Pseudomonas aeruginosa Bacteremia—A Post Hoc Subgroup Analysis From the BALANCE Randomized Controlled Trial

Frequent collaborators

Bradley Langford

Ruxandra Pinto

Gary Garber

Jennie Johnstone

Allison McGeer

Samira Mubareka

Jennifer Tsang

Deborah Cook

Andrew Simor

John Muscedere

Nisha Andany

Bryan Coburn

Miranda So

Erick Duan

Francois Lamontagne

Robert Fowler

Srinivas Murthy

Michael Silverman

John Marshall

Lauralyn McIntyre

Tara Gomes

Beate Sander

Noah Ivers

Ryan Zarychanski

Michelle Science

Kevin Schwartz

Elizabeth Leung

Peter Dodek

Anand Kumar

Peter Daley

François Lauzier

Monica Taljaard

Lisa Schwartz

John Neary

Dawn Bowdish

Murray Krahn

Donald Arnold

Jamie Brehaut

Bram Rochwerg

Nancy Heddle