Richard Roy, McGill University

Research

C. Elegans Ampk Quiescence Amp Activated Protein Kinase (Ampk)Cell Division Chromatin Remodeling Developmental Plasticity Epigenetic Modification

Latest papers

AMPK tunes reproductive gene expression and small RNA homeostasis to mediate timely germ cell development.
Nucleic acids research · 2026 · senior author
AMPK modulates a DEAH box RNA-helicase to attenuate TOR signaling and establish developmental quiescence in Caenorhabditis elegans.
PLoS biology · 2025 · senior author
Neuronal exosomes transport an miRISC cargo to preserve stem cell integrity during energy stress.
Cell reports · 2024 · senior author

All 32 publications

Latest funding

Cryo-3D-super-resolution light microscope for correlative microscopy
NSERC · 2022 · Co-investigator
$150,000
Regulation of germline stem cell quiescence through small RNA-mediated chromatin remodeling
CIHR · 2021 · Nominated PI
$715,275
AMPK blocks epigenetic misregulation and genome instability following acute starvation in C. elegans
CIHR · 2019 · Nominated PI
$673,200

All 13 grants and awards

32 publications.

01

AMPK tunes reproductive gene expression and small RNA homeostasis to mediate timely germ cell development.

Rashid S, Braukmann F, Miska EA, Roy R

Nucleic acids research2026Senior author

DOI: 10.1093/nar/gkag555 PMID: 42258542

02

AMPK modulates a DEAH box RNA-helicase to attenuate TOR signaling and establish developmental quiescence in Caenorhabditis elegans.

Rashid S, Roy R

PLoS biology2025Senior author

DOI: 10.1371/journal.pbio.3003144 PMID: 41325471

03

Neuronal exosomes transport an miRISC cargo to preserve stem cell integrity during energy stress.

Wong C, Jurczak EM, Roy R

Cell reports2024Senior author

DOI: 10.1016/j.celrep.2024.114851 PMID: 39392750

04

Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway.

Wong C, Kadekar P, Jurczak E, Roy R

PLoS genetics2023Senior author

DOI: 10.1371/journal.pgen.1010716 PMID: 37058536

05

Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation.

Sun B, Sherrin M, Roy R

Nucleic acids research2023Senior author

DOI: 10.1093/nar/gkac1155 PMID: 36504323

06

Developmental plasticity and the response to nutrient stress in Caenorhabditis elegans.

Rashid S, Wong C, Roy R

Developmental biology2021Senior author

DOI: 10.1016/j.ydbio.2021.01.015 PMID: 33549550

07

AMPK Regulates Developmental Plasticity through an Endogenous Small RNA Pathway in Caenorhabditis elegans.

Wong C, Roy R

International journal of molecular sciences2020Senior author

DOI: 10.3390/ijms21062238 PMID: 32213851

08

Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling.

Schmeisser S, Li S, Bouchard B, Ruiz M, Des Rosiers C, Roy R

Cell reports2019Senior author

DOI: 10.1016/j.celrep.2019.11.090 PMID: 31875559

09

AMPK regulates germline stem cell quiescence and integrity through an endogenous small RNA pathway.

Kadekar P, Roy R

PLoS biology2019Senior author

DOI: 10.1371/journal.pbio.3000309 PMID: 31166944

10

Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence.

Kadekar P, Chaouni R, Clark E, Kazanets A, Roy R

BMC genomics2018Senior author

DOI: 10.1186/s12864-018-4847-y PMID: 29907081

Cryo-3D-super-resolution light microscope for correlative microscopy

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Strauss, Mike

$150,000

Regulation of germline stem cell quiescence through small RNA-mediated chromatin remodeling

Nominated PICIHR2021Project Grant

Principal investigators: Roy, Richard D

Keywords: Amp Activated Protein Kinase (Ampk); C. Elegans; Cell Division; Chromatin Remodeling; Developmental Plasticity; Epigenetic Modification; Genetic Analysis; Germ Line Stem Cells; Quiescence; Small Rnas

$715,275

AMPK blocks epigenetic misregulation and genome instability following acute starvation in C. elegans

Nominated PICIHR2019Project Grant

Principal investigators: Roy, Richard D

Keywords: Ampk; C. Elegans; Dna Damage; Dripseq/Chipseq; Genome Instability; H3k4me3; R-Loops/Rna/Dna Hybrids; Rad-51; Transcriptional Elongation; Transgenerational Epigenetic Inheritance

$673,200

Characterisation of genes that regulate centriole stability and ciliogenesis

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: ROY, Richard

$168,000

Precise Photo-Manipulation and Rapid Imaging in Developing Organisms

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Lasko, Paul

$149,875

Downstream effectors of LKB1 mediated tumour suppression

Nominated PICIHR2016Project Grant

Principal investigators: Roy, Richard D

Keywords: Ampk; C. Elegans; Cancer; Germline Stem Cells; Lkb1; Notch; Peutz Jeghers Syndrome; Quiescence; Tor Signalling; Tumour Suppressor

$248,463

AMPK-dependent regulation of epigenetic modification links physiology to stem cell integrity

Nominated PICIHR2016Project Grant

Principal investigators: Roy, Richard D

Keywords: Ampk; C. Elegans; Chromatin Modification; Dauer; Epigenetics; Germ Line; Histone Methylation; Rnai; Stem Cells; Transgenerational Phenotypes

$565,731

Uncovering the genetic regulatory network controlling centrosome/cell division coupling/uncoupling and elimination in C. elegans

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Roy, Richard

$200,000

Dissecting the mechanisms required to regulate metabolism and tumour growth downstream of LKB1/AMPK signalling.

Nominated PICIHR2010Operating Grant

Principal investigators: Roy, Richard D

Keywords: Ampk; Autophagy; C. Elegans; Cell Polarity; Dauer; Lipid Hydrolysis/Metabolism; Lkb1; Peutz Jeghers Syndrome; Rnai; Tumour Suppressor

$597,720

Organ-specific regulation of cell growth and division

Nominated PICIHR2008Operating Grant

Principal investigators: Roy, Richard D

Keywords: C. Elegans; Cancer; Cell Cycle; Genetic Analysis; Rnai; Tumour Suppressors

$741,795

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biology
Nutrition
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Matthieu Ruiz

Nutrition

1 shared papers, latest 2019

Christine Des Rosiers

Faculty

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: C. Elegans Dear Professor Roy, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "AMPK tunes reproductive gene expression and small RNA homeostasis to mediate timely germ cell development." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Regulation of germline stem cell quiescence through small RNA-mediated chromatin remodeling" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]