Faculty profile

Siegfried Hekimi

ResearcherBiologyMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Siegfried Hekimi

Researcher

Biology

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
13 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 15 research grants (9 CIHR, 6 NSERC), most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications by year

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Signals and details

Research

Mitochondria Aging C. Elegans Reactive Oxygen Species Coenzyme Q Recycling/Trafficking Coenzyme Q/Ubiquinone Deficiency Hepatitis Virus C Intravenous Administration

Latest papers

Genetic analysis of sensitivity to temperature fluctuations identifies acclimation stress as a novel type of cellular stress in Caenorhabditis elegans.
Genetics · 2026 · senior author
Clarifying the molecular mechanisms underlying the lethal in vitro cellular effects and mild organismal phenotype of SOD1 loss.
Scientific reports · 2026 · senior author
Elevated cellular accumulation of endogenous and exogenous CoQ by altered intracellular trafficking.
The Journal of biological chemistry · 2025 · senior author

All 72 publications

Latest funding

Toward therapies for coenzyme Q10 deficiencies
CIHR · 2026 · Nominated PI
$994,500
Identify and develop small-molecular-weight compounds for the treatment of ubiquinone deficiency and mitochondrial dysfunction.
CIHR · 2018 · Nominated PI
$688,500
ROS metabolism and mitochondrial function in the aging process and in age-dependent diseases.
CIHR · 2017 · Nominated PI
$3,048,055

All 15 grants and awards

72 publications.

Genetic analysis of sensitivity to temperature fluctuations identifies acclimation stress as a novel type of cellular stress in Caenorhabditis elegans.

Lilienfeldt N, Tai Y, Sun H, Waddell B, Yang W, Branicky R, Hekimi S

Genetics2026Senior author

DOI: 10.1093/genetics/iyag157 PMID: 42316942

Clarifying the molecular mechanisms underlying the lethal in vitro cellular effects and mild organismal phenotype of SOD1 loss.

Wang Y, Noë A, Truong-Ong L, Hekimi S

Scientific reports2026Senior author

DOI: 10.1038/s41598-026-59950-5 PMID: 42374077

Elevated cellular accumulation of endogenous and exogenous CoQ by altered intracellular trafficking.

Wang Y, Hekimi S

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2025.110878 PMID: 41197729

Intragenic suppressors of the C. elegans clk-2(qm37) mutation.

Pascal M, Cappadocia L, Hekimi S, Bénard CY

microPublication biology2025

DOI: 10.17912/micropub.biology.001828 PMID: 41122413

Understanding coenzyme Q.

Wang Y, Lilienfeldt N, Hekimi S

Physiological reviews2024Senior author

DOI: 10.1152/physrev.00040.2023 PMID: 38722242

Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation.

Parmar G, Fong-McMaster C, Pileggi CA, Patten DA, Cuillerier A, Myers S, Wang Y, Hekimi S, Cuperlovic-Culf M, Harper ME

The Journal of biological chemistry2024

DOI: 10.1016/j.jbc.2024.105626 PMID: 38211818

Biallelic variants in COQ7 cause distal hereditary motor neuropathy with upper motor neuron signs.

Rebelo AP, Tomaselli PJ, Medina J, Wang Y, Dohrn MF, Nyvltova E, Danzi MC, Garrett M, Smith SE, Pestronk A, Li C, Ruiz A, Jacobs E, Feely SME, França MC, Gomes MV, Santos DF, Kumar S, Lombard DB, Saporta M, Hekimi S, Barrientos A, Weihl C, Shy ME, Marques W, Zuchner S

Brain : a journal of neurology2023

DOI: 10.1093/brain/awad158 PMID: 37170631

Novel Homozygous Variant in COQ7 in Siblings With Hereditary Motor Neuropathy.

Smith IC, Pileggi CA, Wang Y, Kernohan K, Hartley T, McMillan HJ, Sampaio ML, Melkus G, Woulfe J, Parmar G, Bourque PR, Breiner A, Zwicker J, Pringle CE, Jarinova O, Lochmüller H, Dyment DA, Brais B, Boycott KM, Care4Rare Canada Consortium,, Hekimi S, Harper ME, Warman-Chardon J

Neurology. Genetics2023

DOI: 10.1212/nxg.0000000000200048 PMID: 37077559

Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression.

Branicky R, Wang Y, Khaki A, Liu JL, Kramer-Drauberg M, Hekimi S

Science advances2022Senior author

DOI: 10.1126/sciadv.adc9851 PMID: 36449615

Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans.

Haynes CM, Hekimi S

Genetics2022Senior author

DOI: 10.1093/genetics/iyac160 PMID: 36342845