Vanessa Dumeaux, McGill University

Research

Chromatin Development Embryo Epigenetic Inheritance Epigenomics Infertility Obesity Reproduction

Latest papers

Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction.
Molecular metabolism · 2022
The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans.
Genetics · 2022
Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development.
Cell reports · 2021

All 15 publications

Latest funding

Identification of functional epigenomic regions in sperm that are environmentally responsive and associate with fertility and embryo development
CIHR · 2021 · Principal investigator
$879,750
Identifying molecular mechanisms underlying the regulatory role of sperm chromatin in embryo development and adult disease
CIHR · 2021 · Co-investigator
$921,825

All 2 grants and awards

15 publications.

01

Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction.

Pepin AS, Lafleur C, Lambrot R, Dumeaux V, Kimmins S

Molecular metabolism2022

DOI: 10.1016/j.molmet.2022.101463 PMID: 35183795

02

The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans.

Parvizi Omran R, Ramírez-Zavala B, Aji Tebung W, Yao S, Feng J, Law C, Dumeaux V, Morschhäuser J, Whiteway M

Genetics2022

DOI: 10.1093/genetics/iyab155 PMID: 34849863

03

Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development.

Lambrot R, Chan D, Shao X, Aarabi M, Kwan T, Bourque G, Moskovtsev S, Librach C, Trasler J, Dumeaux V, Kimmins S

Cell reports2021

DOI: 10.1016/j.celrep.2021.109418 PMID: 34289352

04

ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance.

Lismer A, Lambrot R, Lafleur C, Dumeaux V, Kimmins S

STAR protocols2021

DOI: 10.1016/j.xpro.2021.100602 PMID: 34159325

05

Signal-mediated localization of Candida albicans pheromone response pathway components.

Costa ACBP, Omran RP, Law C, Dumeaux V, Whiteway M

G3 (Bethesda, Md.)2021

DOI: 10.1093/g3journal/jkaa033 PMID: 33793759

06

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Lismer A, Dumeaux V, Lafleur C, Lambrot R, Brind'Amour J, Lorincz MC, Kimmins S

Developmental cell2021

DOI: 10.1016/j.devcel.2021.01.014 PMID: 33596408

07

Modulation of the complex regulatory network for methionine biosynthesis in fungi.

Shrivastava M, Feng J, Coles M, Clark B, Islam A, Dumeaux V, Whiteway M

Genetics2021

DOI: 10.1093/genetics/iyaa049 PMID: 33724418

08

Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance.

Lismer A, Siklenka K, Lafleur C, Dumeaux V, Kimmins S

Nucleic acids research2020

DOI: 10.1093/nar/gkaa712 PMID: 33068438

09

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG

Cell reports2020

DOI: 10.1016/j.celrep.2020.107838 PMID: 32610139

10

Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1.

Costa ACBP, Omran RP, Correia-Mesquita TO, Dumeaux V, Whiteway M

Scientific reports2019

DOI: 10.1038/s41598-019-45624-y PMID: 31235750

Identification of functional epigenomic regions in sperm that are environmentally responsive and associate with fertility and embryo development

Principal investigatorCIHR2021Project Grant

Principal investigators: Kimmins, Sarah; Dumeaux, Vanessa

Keywords: Chromatin; Development; Embryo; Epigenetic Inheritance; Epigenomics; Infertility; Obesity; Reproduction; Sperm; Transcription

$879,750

Identifying molecular mechanisms underlying the regulatory role of sperm chromatin in embryo development and adult disease

Co-investigatorCIHR2021Project Grant

Principal investigators: Kimmins, Sarah

Keywords: Development; Embryo; Epigenetic Inheritance; Epigenomics; Infertility; Intervention; Nutrition; Obesity; Reproduction; Sperm

$921,825

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Oncology
Animal Science
Human Genetics
Pathology & Cell Biology
Biomedical Engineering
Radiation Oncology
Pediatrics
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Sarah Kimmins

Pathology & Cell Biology

5 shared papers, latest 2022

Sarah Kimmins

Animal Science

5 shared papers, latest 2022

Rinku Sutradhar

Institute of Health Policy, Management, and Evaluation

1 shared papers, latest 2019

ATILLA Omeroglu

Biomedical Engineering

1 shared papers, latest 2014

Yasser Riazalhosseini

Human Genetics

1 shared papers, latest 2014

Guillaume Bourque

Human Genetics

1 shared papers, latest 2021

Eileen Rakovitch

Radiation Oncology

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Chromatin Dear Professor Dumeaux, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Identification of functional epigenomic regions in sperm that are environmentally responsive and associate with fertility and embryo development" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Vanessa Dumeaux

Research

Latest papers

Latest funding

Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction.

The zinc cluster transcription factor Rha1 is a positive filamentation regulator in Candida albicans.

Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development.

ChIP-seq protocol for sperm cells and embryos to assess environmental impacts and epigenetic inheritance.

Signal-mediated localization of Candida albicans pheromone response pathway components.

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.

Modulation of the complex regulatory network for methionine biosynthesis in fungi.

Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance.

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.

Screening of Candida albicans GRACE library revealed a unique pattern of biofilm formation under repression of the essential gene ILS1.

Identification of functional epigenomic regions in sperm that are environmentally responsive and associate with fertility and embryo development

Identifying molecular mechanisms underlying the regulatory role of sperm chromatin in embryo development and adult disease

Frequent collaborators

Sarah Kimmins

Sarah Kimmins

Rinku Sutradhar

Morag Park

Vanessa Dumeaux

ATILLA Omeroglu

Jacquetta Trasler

Morag Park

Yasser Riazalhosseini

Guillaume Bourque

Lawrence Paszat

Timothy Whelan

Eileen Rakovitch