Marc Lavertu, Polytechnique Montréal

Research

Chitosan Biomechanics Cartilage Ligament Manufacturing scale-up Meniscus Orthobiologics Platelet-Rich Plasma

Latest papers

Chitosan-fibrinogen-thrombin matrix accelerates re-epithelialization and cornification in a rat wound healing model.
NPJ Regenerative medicine · 2026 · senior author
Title Freeze-Dried Chitosan-Thrombin-Platelet-Rich Plasma Implants Improve Supraspinatus Tendon Regeneration in a Rabbit Rotator Cuff Repair Model.
ACS biomaterials science & engineering · 2025 · senior author
Chitosan/Platelet-Rich Plasma Implants in an Ovine Arthroscopic Model of Meniscus Repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025 · senior author

All 36 publications

Latest funding

First Canadian Connective Tissue Workshop Focused on Industry, Entrepreneurship & Patient Engagement
CIHR · 2022 · Principal investigator
$19,070
Chitosan/Orthobiologics Biomaterials for Regenerative Medicine
NSERC · 2022 · Principal investigator
$868,000
Adhesion-based cell sorter
NSERC · 2020 · Co-investigator
$150,000

All 5 grants and awards

36 publications.

01

Chitosan-fibrinogen-thrombin matrix accelerates re-epithelialization and cornification in a rat wound healing model.

Lerhcha H, Chevrier A, Lavertu M

NPJ Regenerative medicine2026Senior author

DOI: 10.1038/s41536-026-00486-7 PMID: 42350458

02

Title Freeze-Dried Chitosan-Thrombin-Platelet-Rich Plasma Implants Improve Supraspinatus Tendon Regeneration in a Rabbit Rotator Cuff Repair Model.

Milano F, Chevrier A, De Crescenzo G, Lavertu M

ACS biomaterials science & engineering2025Senior author

DOI: 10.1021/acsbiomaterials.5c01414 PMID: 41104707

03

Chitosan/Platelet-Rich Plasma Implants in an Ovine Arthroscopic Model of Meniscus Repair.

Delvaux M, Chevrier A, Sim S, Quenneville É, Hurtig MB, De Crescenzo G, Lavertu M

Journal of orthopaedic research : official publication of the Orthopaedic Research Society2025Senior author

DOI: 10.1002/jor.70014 PMID: 40605350

04

Comparative Analysis of Chitosan, Lipid Nanoparticles, and Alum Adjuvants in Recombinant SARS-CoV-2 Vaccine: An Evaluation of Their Immunogenicity and Serological Efficacy.

Ghattas M, Dwivedi G, Chevrier A, Scobey T, El-Mayta R, Mattocks MD, Wang D, Lavertu M, Alameh MG

Vaccines2025

DOI: 10.3390/vaccines13080788 PMID: 40872875

05

Impact of BMI and PRP Platelet and Red Blood Cell Content on the Coagulation Kinetics of Ortho-R/PRP Mixtures.

Chevrier A, Lavertu M

Polymers2025Senior author

DOI: 10.3390/polym17111515 PMID: 40508758

06

Monitoring mRNA vaccine antigen expression in vivo using PET/CT.

Blizard GS, Dwivedi G, Pan YG, Hou C, Etersque JM, Said H, Chevrier A, Lavertu M, Ni H, Davis B, Tam Y, Cao Q, Mach RH, Weissman D, Alameh MG, Sellmyer MA

Nature communications2025

DOI: 10.1038/s41467-025-57446-w PMID: 40044669

07

Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways.

Ghattas M, Dwivedi G, Chevrier A, Horn-Bourque D, Alameh MG, Lavertu M

RSC advances2025Senior author

DOI: 10.1039/d4ra08406c PMID: 39802469

08

A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection.

Alameh MG, Semon A, Bayard NU, Pan YG, Dwivedi G, Knox J, Glover RC, Rangel PC, Tanes C, Bittinger K, She Q, Hu H, Bonam SR, Maslanka JR, Planet PJ, Moustafa AM, Davis B, Chevrier A, Beattie M, Ni H, Blizard G, Furth EE, Mach RH, Lavertu M, Sellmyer MA, Tam Y, Abt MC, Weissman D, Zackular JP

Science (New York, N.Y.)2024

DOI: 10.1126/science.adn4955 PMID: 39361752

09

Manufacturing Process Affects Coagulation Kinetics of Ortho-R, an Injectable Chitosan-Platelet-Rich Plasma Biomaterial for Tissue Repair.

Chevrier A, Lavertu M

Bioengineering (Basel, Switzerland)2024Senior author

DOI: 10.3390/bioengineering11090929 PMID: 39329671

10

Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.

Alameh MG, Tavakoli Naeini A, Dwivedi G, Lesage F, Buschmann MD, Lavertu M

Polymers2024Senior author

DOI: 10.3390/polym16172547 PMID: 39274180

First Canadian Connective Tissue Workshop Focused on Industry, Entrepreneurship & Patient Engagement

Principal investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Changoor, Adele; Lavertu, Marc

Keywords: Connective Tissue Research; Entrepreneurship; Equity, Diversity, Inclusion; Industry Careers; Knowlege Transfer; Patient Engagement; Workshop

$19,070

Chitosan/Orthobiologics Biomaterials for Regenerative Medicine

Principal investigatorNSERC2022Alliance Grants

Principal investigators: Lavertu, Marc M

Keywords: biomechanics; cartilage; chitosan; ligament; manufacturing scale-up; meniscus; orthobiologics; platelet-rich plasma; regenerative medicine; tendon

$868,000

Adhesion-based cell sorter

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Banquy, Xavier

$150,000

Polymeric Nanoparticles for Delivery of Ribonucleic Acids: Overcoming the Endosomal Barrier and Going Beyond the Liver

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Lavertu, Marc

Keywords: Biodistribution; Chitosan; Endosomal escape; Endosomolytic moiety; Gene delivery; Hydrophobically modified polymer; Intracellular trafficking; mRNA; Nanoparticles; siRNA

$168,000

Electrospray-Differential Mobility Analysis System for the Analysis of Biomacromolecules, Polymeric (Bio)Materials and Nanoparticles

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Buschmann, Michael

$149,560

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Génie chimique
Chemical Engineering
Pharmacologie - Physiologie
Infection and Immunology

Co-authors at Polytechnique Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Gregory De Crescenzo

Génie chimique

4 shared papers, latest 2025

Frédéric Lesage

Pharmacologie - Physiologie

2 shared papers, latest 2024

Abderrazzak Merzouki

Chemical Engineering

2 shared papers, latest 2013

Frédéric Lesage

Faculty

2 shared papers, latest 2024

Sachiko Sato

Infection and Immunology

1 shared papers, latest 2017

Mario Jolicoeur

Génie chimique

1 shared papers, latest 2013

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Chitosan Dear Professor Lavertu, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Chitosan-fibrinogen-thrombin matrix accelerates re-epithelialization and cornification in a rat wound healing model." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "First Canadian Connective Tissue Workshop Focused on Industry, Entrepreneurship & Patient Engagement" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]