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Research
Latest papers
Editorial: Exploring the role of epigenetic modifications in pulmonary vascular disease pathogenesis.
Frontiers in medicine · 2025
Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.
Nature cardiovascular research · 2023
An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats.
Frontiers in physiology · 2022
Latest funding
- $864,450
Epigenome wide study for the investigation of DNA methylation as therapeutic target and novel biomarker of pulmonary arterial hypertension.
CIHR · 2021 · Nominated PI
- $183,050
An innovative minimally invasive modular right ventricular assist device
NSERC · 2021 · Co-investigator
- $891,225
Dysregulation of TET2 and DNMT3A promotes pulmonary arterial hypertension (PAH) through inflammation : A new mechanism of PAH
CIHR · 2020 · Co-investigator
12 publications.
Editorial: Exploring the role of epigenetic modifications in pulmonary vascular disease pathogenesis.
Prisco SZ, Umar S, Potus F, Agrawal V
Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.
Khassafi F, Chelladurai P, Valasarajan C, Nayakanti SR, Martineau S, Sommer N, Yokokawa T, Boucherat O, Kamal A, Kiely DG, Swift AJ, Alabed S, Omura J, Breuils-Bonnet S, Kuenne C, Potus F, Günther S, Savai R, Seeger W, Looso M, Lawrie A, Zaugg JB, Tello K, Provencher S, Bonnet S, Pullamsetti SS
An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats.
Hindmarch CCT, Tian L, Xiong PY, Potus F, Bentley RET, Al-Qazazi R, Prins KW, Archer SL
Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension.
Al-Qazazi R, Lima PDA, Prisco SZ, Potus F, Dasgupta A, Chen KH, Tian L, Bentley RET, Mewburn J, Martin AY, Wu D, Jones O, Maurice DH, Bonnet S, Provencher S, Prins KW, Archer SL
Recent advancements in pulmonary arterial hypertension and right heart failure research: overview of selected abstracts from ATS2020 and emerging COVID-19 research.
Potus F, Frump AL, Umar S, R Vanderpool R, Al Ghouleh I, Lai YC
PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension.
Dasgupta A, Chen KH, Lima PDA, Mewburn J, Wu D, Al-Qazazi R, Jones O, Tian L, Potus F, Bonnet S, Archer SL
17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin.
Frump AL, Albrecht M, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez B, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T
Pulmonary hypertension thresholds: time to lower further?
Provencher S, Boucherat O, Potus F, Bonnet S
Dual ETA/ETB blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension.
Nadeau V, Potus F, Boucherat O, Paradis R, Tremblay E, Iglarz M, Paulin R, Bonnet S, Provencher S
MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.
Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary K, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL
Epigenome wide study for the investigation of DNA methylation as therapeutic target and novel biomarker of pulmonary arterial hypertension.
Principal investigators: Potus, Francois
Keywords: Biomarker & Therapeutics; Blood; Dna Methylation; Epigenetic; Familial & Hereditary Pulmonary Hypertension; Human Tissues; Methylome; Pulmonary Hypertension; Transcriptomic; Translational L
An innovative minimally invasive modular right ventricular assist device
Principal investigators: KADEM, Lyes L
Dysregulation of TET2 and DNMT3A promotes pulmonary arterial hypertension (PAH) through inflammation : A new mechanism of PAH
Principal investigators: Rauh, Michael
Keywords: Dnmt3a; Epigenetics; Gene Expression; Genetics; Human Subjects; Inflammation; Murine Models; Pulmonary Hypertension; Tet2; Translational Biomarkers & Therapeutics
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Médecine
- Medicine
- Biomedical and Molecular Sciences
- Other
Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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