Jacques Lapointe, Université Laval

Research

Read how they describe their research on their Université Laval profile.

Latest papers

Inhibition of Helicobacter pylori Glu-tRNAGln amidotransferase by novel analogues of the putative transamidation intermediate.
FEBS letters · 2016
Cyclic peptides identified by phage display are competitive inhibitors of the tRNA-dependent amidotransferase of Helicobacter pylori.
Peptides · 2016 · senior author
tRNAGlu increases the affinity of glutamyl-tRNA synthetase for its inhibitor glutamyl-sulfamoyl-adenosine, an analogue of the aminoacylation reaction intermediate glutamyl-AMP: mechanistic and evolutionary implications.
PloS one · 2015 · senior author

All 13 publications

Latest funding

Spectrophotomètre pour cinétiques enzymatiques
NSERC · 2012 · Co-investigator
$61,376
Protein/tRNA and conformational changes involved in the faithful aminoacylation of tRNAs specific for glutamate, glutamine, aspartate and aspargine
NSERC · 2010 · Principal investigator
$280,000
Compteur à scintillations
NSERC · 2007 · Co-investigator
$34,667

All 22 grants and awards

13 publications.

01

Inhibition of Helicobacter pylori Glu-tRNAGln amidotransferase by novel analogues of the putative transamidation intermediate.

Pham VH, Maaroufi H, Balg C, Blais SP, Messier N, Roy PH, Otis F, Voyer N, Lapointe J, Chênevert R

FEBS letters2016

DOI: 10.1002/1873-3468.12380 PMID: 27586694

02

Cyclic peptides identified by phage display are competitive inhibitors of the tRNA-dependent amidotransferase of Helicobacter pylori.

Pham VH, Maaroufi H, Levesque RC, Lapointe J

Peptides2016Senior author

DOI: 10.1016/j.peptides.2016.03.001 PMID: 26976271

03

tRNAGlu increases the affinity of glutamyl-tRNA synthetase for its inhibitor glutamyl-sulfamoyl-adenosine, an analogue of the aminoacylation reaction intermediate glutamyl-AMP: mechanistic and evolutionary implications.

Blais SP, Kornblatt JA, Barbeau X, Bonnaure G, Lagüe P, Chênevert R, Lapointe J

PloS one2015Senior author

DOI: 10.1371/journal.pone.0121043 PMID: 25860020

04

Natural insertion of the bro-1 β-lactamase gene into the gatCAB operon affects Moraxella catarrhalis aspartyl-tRNA(Asn) amidotransferase activity.

Akochy PM, Lapointe J, Roy PH

Microbiology (Reading, England)2012

DOI: 10.1099/mic.0.060095-0 PMID: 22745266

05

Gln-tRNAGln synthesis in a dynamic transamidosome from Helicobacter pylori, where GluRS2 hydrolyzes excess Glu-tRNAGln.

Huot JL, Fischer F, Corbeil J, Madore E, Lorber B, Diss G, Hendrickson TL, Kern D, Lapointe J

Nucleic acids research2011Senior author

DOI: 10.1093/nar/gkr619 PMID: 21813455

06

Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by chloramphenicol analogs.

Balg C, De Mieri M, Huot JL, Blais SP, Lapointe J, Chênevert R

Bioorganic & medicinal chemistry2010

DOI: 10.1016/j.bmc.2010.09.045 PMID: 20943400

07

A C-truncated glutamyl-tRNA synthetase specific for tRNA(Glu) is stimulated by its free complementary distal domain: mechanistic and evolutionary implications.

Dubois DY, Blais SP, Huot JL, Lapointe J

Biochemistry2009Senior author

DOI: 10.1021/bi801690f PMID: 19496540

08

Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by puromycin analogues.

Balg C, Huot JL, Lapointe J, Chênevert R

Journal of the American Chemical Society2008

DOI: 10.1021/ja7100714 PMID: 18293984

09

Mechanism of a GatCAB amidotransferase: aspartyl-tRNA synthetase increases its affinity for Asp-tRNA(Asn) and novel aminoacyl-tRNA analogues are competitive inhibitors.

Huot JL, Balg C, Jahn D, Moser J, Emond A, Blais SP, Chênevert R, Lapointe J

Biochemistry2007Senior author

DOI: 10.1021/bi700602n PMID: 17929881

10

Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases.

Balg C, Blais SP, Bernier S, Huot JL, Couture M, Lapointe J, Chênevert R

Bioorganic & medicinal chemistry2007

DOI: 10.1016/j.bmc.2006.09.056 PMID: 17049867

Spectrophotomètre pour cinétiques enzymatiques

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Levesque, Roger

$61,376

Protein/tRNA and conformational changes involved in the faithful aminoacylation of tRNAs specific for glutamate, glutamine, aspartate and aspargine

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Lapointe, Jacques

$280,000

Compteur à scintillations

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Bernier, Louis

$34,667

Centre de bio-informatique

Co-investigatorNSERC2006Major Facilities Access Grants

Principal investigators: Lemieux, Claude

$65,100

Structure/function studies of bacterial glutamyl- and aspartyl-tRNA synthetases, and of the novel synthetase encoded

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Lapointe, Jacques

$334,400

Freeze dryer

Co-investigatorNSERC2002Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Auger, Michèle

$15,653

Centre de bioinformatique

Co-investigatorNSERC2002Major Facilities Access Grants

Principal investigators: Bousquet, Jean

$210,000

Nuclear Magnetic Resonance Facility for the Study of Protein Structure

Co-investigatorCFI2000Innovation Fund: Innovation Fund (1999-2005)

Principal investigators: Voyer, Normand

Keywords: Protein structure and function, Biological NMR, Structural biology, Structural proteomics, High-field NMR

$800,000

Synthesis and characterization of glutamyl-tRNA synthetase (GLuRS) inhibitors with antibiotic properties, and use of resistant mutants to study the biosynthesis of this enzyme

Principal investigatorNSERC2000Collaborative Research and Development Grants

Principal investigators: Lapointe, Jacques

$55,000

Purchase of a MALDI-TOF (Matrix assisted laser desorption/ionisation time-of-flight) mass spectrometer

Co-investigatorNSERC2000Research Tools and Instruments - Category 2 ($150,000 - $325,000)

Principal investigators: Poirier, Guy

$210,543

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Frequent collaborators

Prix Et Distinctions
Molecular Medicine
Biochemistry, microbiology and bioinformatics

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Jacques Corbeil

Molecular Medicine

1 shared papers, latest 2011

Manon Couture

Biochemistry, microbiology and bioinformatics

1 shared papers, latest 2007

Normand Voyer

Prix Et Distinctions

1 shared papers, latest 2016

Write to this professor

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Applying for

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Subject: Prospective PhD student Dear Professor Lapointe, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Inhibition of Helicobacter pylori Glu-tRNAGln amidotransferase by novel analogues of the putative transamidation intermediate." (2016), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jacques Lapointe

Research

Latest papers

Latest funding

Inhibition of Helicobacter pylori Glu-tRNAGln amidotransferase by novel analogues of the putative transamidation intermediate.

Cyclic peptides identified by phage display are competitive inhibitors of the tRNA-dependent amidotransferase of Helicobacter pylori.

tRNAGlu increases the affinity of glutamyl-tRNA synthetase for its inhibitor glutamyl-sulfamoyl-adenosine, an analogue of the aminoacylation reaction intermediate glutamyl-AMP: mechanistic and evolutionary implications.

Natural insertion of the bro-1 &#x3b2;-lactamase gene into the gatCAB operon affects Moraxella catarrhalis aspartyl-tRNA(Asn) amidotransferase activity.

Gln-tRNAGln synthesis in a dynamic transamidosome from Helicobacter pylori, where GluRS2 hydrolyzes excess Glu-tRNAGln.

Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by chloramphenicol analogs.

A C-truncated glutamyl-tRNA synthetase specific for tRNA(Glu) is stimulated by its free complementary distal domain: mechanistic and evolutionary implications.

Inhibition of Helicobacter pylori aminoacyl-tRNA amidotransferase by puromycin analogues.

Mechanism of a GatCAB amidotransferase: aspartyl-tRNA synthetase increases its affinity for Asp-tRNA(Asn) and novel aminoacyl-tRNA analogues are competitive inhibitors.

Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases.

Spectrophotomètre pour cinétiques enzymatiques

Protein/tRNA and conformational changes involved in the faithful aminoacylation of tRNAs specific for glutamate, glutamine, aspartate and aspargine

Compteur à scintillations

Centre de bio-informatique

Structure/function studies of bacterial glutamyl- and aspartyl-tRNA synthetases, and of the novel synthetase encoded

Freeze dryer

Centre de bioinformatique

Nuclear Magnetic Resonance Facility for the Study of Protein Structure

Synthesis and characterization of glutamyl-tRNA synthetase (GLuRS) inhibitors with antibiotic properties, and use of resistant mutants to study the biosynthesis of this enzyme

Purchase of a MALDI-TOF (Matrix assisted laser desorption/ionisation time-of-flight) mass spectrometer

Frequent collaborators

Jacques Corbeil

Manon Couture

Normand Voyer

Natural insertion of the bro-1 β-lactamase gene into the gatCAB operon affects Moraxella catarrhalis aspartyl-tRNA(Asn) amidotransferase activity.