Faculty profile

Manon Couture

ResearcherBiochemistry, microbiology and bioinformaticsUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Manon Couture

Researcher

Biochemistry, microbiology and bioinformatics

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
1 publication in the last five years, latest in 2024.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 6 research grants (6 NSERC), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Antibacterials Bacterial metabolism Enzyme kinetics Escherichia coli O157:H7 Heme-iron metabolism Heme oxygenase Microbiology Raman spectroscopy

Latest papers

The heme binding protein ChuX is a regulator of heme degradation by the ChuS protein in Escherichia coli O157:H7.
Journal of inorganic biochemistry · 2024 · senior author
Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19.
Nature medicine · 2021
Effects of Hexane on Protein Profile, Solubility and Foaming Properties of Defatted Proteins Extracted from Tenebrio molitor Larvae.
Molecules (Basel, Switzerland) · 2021

All 22 publications

Latest funding

Direct write photolithography for advanced microsystems: chemistry to life sciences
NSERC · 2024 · Co-investigator
$150,000
Biochemical and functional characterization of proteins and enzymes for heme-iron acquisition and utilisation in bacteria
NSERC · 2019 · Principal investigator
$192,000
Cell Grower : High-throughput measurements of microbial growths
NSERC · 2017 · Co-investigator
$77,425

All 11 grants and awards

22 publications.

The heme binding protein ChuX is a regulator of heme degradation by the ChuS protein in Escherichia coli O157:H7.

Ye D, Nguyen PT, Bourgault S, Couture M

Journal of inorganic biochemistry2024Senior author

DOI: 10.1016/j.jinorgbio.2024.112575 PMID: 38678912

Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19.

Ward BJ, Gobeil P, Séguin A, Atkins J, Boulay I, Charbonneau PY, Couture M, D'Aoust MA, Dhaliwall J, Finkle C, Hager K, Mahmood A, Makarkov A, Cheng MP, Pillet S, Schimke P, St-Martin S, Trépanier S, Landry N

Nature medicine2021

DOI: 10.1038/s41591-021-01370-1 PMID: 34007070

Effects of Hexane on Protein Profile, Solubility and Foaming Properties of Defatted Proteins Extracted from Tenebrio molitor Larvae.

Gravel A, Marciniak A, Couture M, Doyen A

Molecules (Basel, Switzerland)2021

DOI: 10.3390/molecules26020351 PMID: 33445507

Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism.

Pham VD, To TA, Gagné-Thivierge C, Couture M, Lagüe P, Yao D, Picard MÈ, Lortie LA, Attéré SA, Zhu X, Levesque RC, Charette SJ, Shi R

The Journal of biological chemistry2020

DOI: 10.1074/jbc.ra119.011809 PMID: 32371400

Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations.

Manenda MS, Picard MÈ, Zhang L, Cyr N, Zhu X, Barma J, Pascal JM, Couture M, Zhang C, Shi R

The Journal of biological chemistry2020

DOI: 10.1074/jbc.ra119.011212 PMID: 32111738

Resonance Raman studies on the flavohemoglobin of the protist Giardia intestinalis: evidence of a type I/II-peroxidase-like heme environment and roles of the active site distal residues.

Lukaszewicz B, McColl E, Yee J, Rafferty S, Couture M

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2017Senior author

DOI: 10.1007/s00775-017-1487-7 PMID: 28884403

Reaction Intermediates and Molecular Mechanism of Peroxynitrite Activation by NO Synthases.

Lang J, Maréchal A, Couture M, Santolini J

Biophysical journal2016

DOI: 10.1016/j.bpj.2016.05.056 PMID: 27851935

Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis.

Zhu Y, Picard MÈ, Zhang Q, Barma J, Després XM, Mei X, Zhang L, Duvignaud JB, Couture M, Zhu W, Shi R, Zhang C

Chemical science2016

DOI: 10.1039/c6sc00771f PMID: 30155134

Oxygen activation in NO synthases: evidence for a direct role of the substrate.

Brunel A, Lang J, Couture M, Boucher JL, Dorlet P, Santolini J

FEBS open bio2016

DOI: 10.1002/2211-5463.12036 PMID: 27419044

An alternative reaction for heme degradation catalyzed by the Escherichia coli O157:H7 ChuS protein: Release of hematinic acid, tripyrrole and Fe(III).

Ouellet YH, Ndiaye CT, Gagné SM, Sebilo A, Suits MD, Jubinville É, Jia Z, Ivancich A, Couture M

Journal of inorganic biochemistry2016Senior author

DOI: 10.1016/j.jinorgbio.2015.11.002 PMID: 26598215

Direct write photolithography for advanced microsystems: chemistry to life sciences

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Greener, Jesse

Keywords: Bacteriology; Biomedical materials; Biomedical sensors and implants; Lab-on-a-chip (electrochemistry, spectroscopy, microscopy); Microfluidics, MEMS and Micro-electronics; Microscale reactors and assays; Optoelectronics; Photolithography; Sustainable plastics; Water quality

$150,000

Biochemical and functional characterization of proteins and enzymes for heme-iron acquisition and utilisation in bacteria

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Couture, Manon

Keywords: Antibacterials; Bacterial metabolism; Enzyme kinetics; Escherichia coli O157:H7; Heme-iron metabolism; Heme oxygenase; Microbiology; Raman spectroscopy; Structure and function of heme proteins

$192,000

Cell Grower : High-throughput measurements of microbial growths

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Landry, Christian

$77,425

Spectrophotomètre pour cinétiques enzymatiques

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Levesque, Roger

$61,376

Mechanisms of molecular oxygen and peroxide activation by the nitric oxide synthases and the heme degrading enzyme ChuS

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Couture, Manon

$170,000

Green DPSS laser for nanoparticles characterization by SERS and rRaman spectroscopy of heme proteins

Principal investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Couture, Manon

$7,860

The mechanisms of nitric oxyde synthesis by nitric oxide synthases

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Couture, Manon

$210,000

Thermal mass flow gas-mixer

Co-investigatorNSERC2004Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Guertin, Michel

$20,026

Resonance Raman Spectroscopy System for the Biophysical Characterization of Heme Proteins

Principal investigatorNSERC2002Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Couture, Manon

$97,000

Stopped-flow reaction analyser

Co-investigatorNSERC2002Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Guertin, Michel

$29,004

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Manon Couture

Research

Latest papers

Latest funding

The heme binding protein ChuX is a regulator of heme degradation by the ChuS protein in Escherichia coli O157:H7.

Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19.

Effects of Hexane on Protein Profile, Solubility and Foaming Properties of Defatted Proteins Extracted from Tenebrio molitor Larvae.

Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism.

Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations.

Resonance Raman studies on the flavohemoglobin of the protist Giardia intestinalis: evidence of a type I/II-peroxidase-like heme environment and roles of the active site distal residues.

Reaction Intermediates and Molecular Mechanism of Peroxynitrite Activation by NO Synthases.

Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis.

Oxygen activation in NO synthases: evidence for a direct role of the substrate.

An alternative reaction for heme degradation catalyzed by the Escherichia coli O157:H7 ChuS protein: Release of hematinic acid, tripyrrole and Fe(III).

Direct write photolithography for advanced microsystems: chemistry to life sciences

Biochemical and functional characterization of proteins and enzymes for heme-iron acquisition and utilisation in bacteria

Cell Grower : High-throughput measurements of microbial growths

Spectrophotomètre pour cinétiques enzymatiques

Mechanisms of molecular oxygen and peroxide activation by the nitric oxide synthases and the heme degrading enzyme ChuS

Green DPSS laser for nanoparticles characterization by SERS and rRaman spectroscopy of heme proteins

The mechanisms of nitric oxyde synthesis by nitric oxide synthases

Thermal mass flow gas-mixer

Resonance Raman Spectroscopy System for the Biophysical Characterization of Heme Proteins

Stopped-flow reaction analyser

Frequent collaborators

Rong Shi

Michel Cusson

Janet Yee

Steven Rafferty

Alain Doyen

Steve Bourgault

Zongchao Jia