Roxane Pouliot, Université Laval

Research

Génie Tissulaire Peau Psoriasis Fonction Barrière Kératinocytes Libération Contrôlée Nouveau Traitement Pénétration Cutanée Non-Invasive

Latest papers

Alteration of epidermal lipid metabolism by 2-linoleoylglycerol in a 3D skin model.
Scientific reports · 2026 · senior author
Linoleic acid concentration at the air-liquid interface is key for optimal incorporation into skin model lipidome.
Frontiers in physiology · 2026 · senior author
A tissue-engineered human psoriatic skin model: targeting inflammation and glucose metabolism dysregulation in psoriasis using microneedle patches.
Frontiers in molecular biosciences · 2026 · senior author

All 56 publications

Latest funding

Breaking barriers in drug delivery via using viscoplastic fluids for precise control of jet evolution and penetration
SSHRC · 2023 · Co-investigator
$250,000
A human tissue-engineered three-layer cornea (hTEC) supplemented with macrophages as a biomaterial for in vitro studies
CIHR · 2023 · Co-investigator
$864,450
Nouvelles options thérapeutiques pour les patients atteints de psoriasis
CIHR · 2019 · Nominated PI
$677,026

All 13 grants and awards

56 publications.

01

Alteration of epidermal lipid metabolism by 2-linoleoylglycerol in a 3D skin model.

Tremblay A, Simard M, Larouche A, Dumais É, Julien P, Flamand N, Pouliot R

Scientific reports2026Senior author

DOI: 10.1038/s41598-026-60336-w PMID: 42431977

02

Linoleic acid concentration at the air-liquid interface is key for optimal incorporation into skin model lipidome.

Tremblay A, Larouche A, Simard M, Dumais É, Julien P, Flamand N, Pouliot R

Frontiers in physiology2026Senior author

DOI: 10.3389/fphys.2026.1838020 PMID: 42441238

03

A tissue-engineered human psoriatic skin model: targeting inflammation and glucose metabolism dysregulation in psoriasis using microneedle patches.

Ruel Y, Moawad F, Cortez Ghio S, Brambilla D, Pouliot R

Frontiers in molecular biosciences2026Senior author

DOI: 10.3389/fmolb.2026.1830240 PMID: 42344152

04

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges.

Moawad F, Ruel Y, Pouliot R, Brambilla D

Advanced healthcare materials2026

DOI: 10.1002/adhm.202504294 PMID: 41334788

05

Toward Long-Acting Psoriasis Therapy with Phloretin-Loaded Microneedle Patches: Insights from In Vitro Patient-Derived Skin Models.

Ruel Y, Moawad F, Jean E, Nadeau C, Alsarraf J, Pichette A, Legault J, Brambilla D, Pouliot R

ACS pharmacology & translational science2025Senior author

DOI: 10.1021/acsptsci.5c00361 PMID: 40969878

06

Dissolving microneedles in transdermal drug delivery: A critical analysis of limitations and translation challenges.

Moawad F, Pouliot R, Brambilla D

Journal of controlled release : official journal of the Controlled Release Society2025

DOI: 10.1016/j.jconrel.2025.113794 PMID: 40319916

07

Microneedles with Implantable Tip-Accumulated Therapeutics for the Long-Term Management of Psoriasis.

Moawad F, Ruel Y, Rezaei N, Alsarraf J, Pichette A, Legault J, Pouliot R, Brambilla D

Small (Weinheim an der Bergstrasse, Germany)2024

DOI: 10.1002/smll.202405927 PMID: 39375985

08

Sensory neurons increase keratinocyte proliferation through CGRP release in a tissue engineered in vitro model of innervation in psoriasis.

Pepin R, Ringuet J, Beaudet MJ, Bellenfant S, Galbraith T, Veillette H, Pouliot R, Berthod F

Acta biomaterialia2024

DOI: 10.1016/j.actbio.2024.05.021 PMID: 38750917

09

Antiproliferative and Anti-Inflammatory Effects of the Polyphenols Phloretin and Balsacone C in a Coculture of T Cells and Psoriatic Keratinocytes.

Ruel Y, Moawad F, Alsarraf J, Pichette A, Legault J, Brambilla D, Pouliot R

International journal of molecular sciences2024Senior author

DOI: 10.3390/ijms25115639 PMID: 38891824

10

Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles.

Moawad F, Le Meur M, Ruel Y, Gaëlle Roullin V, Pouliot R, Brambilla D

International journal of pharmaceutics2024

DOI: 10.1016/j.ijpharm.2023.123676 PMID: 38056795

Breaking barriers in drug delivery via using viscoplastic fluids for precise control of jet evolution and penetration

Co-investigatorSSHRC2023New Frontiers in Research Fund - Exploration

Principal investigators: Taghavi, Seyed Mohammad

Keywords: Fluid mechanics; Viscoplastic fluids; Needle-free injection; Non-Newtonian fluid mechanics; Modeling complex flows; Rheology; Drug injection; Multilayer skin model

$250,000

A human tissue-engineered three-layer cornea (hTEC) supplemented with macrophages as a biomaterial for in vitro studies

Co-investigatorCIHR2023Project Grant

Principal investigators: Guerin, Sylvain L

Keywords: Biomaterial; Clusterin Gene; Corneal Wound Healing; Human Corneal Endothelial Cells; Human Corneal Epithelial Cells; Human Corneal Stromal Stem Cells; Human Immune Cells; Signal Transduction Pathways; Tissue Engineered Human Cornea

$864,450

Nouvelles options thérapeutiques pour les patients atteints de psoriasis

Nominated PICIHR2019Project Grant

Principal investigators: Pouliot, Roxane

Keywords: Fonction Barrière; Génie Tissulaire; Kératinocytes; Libération Contrôlée; Nouveau Traitement; Peau; Psoriasis; Pénétration Cutanée Non-Invasive; Substituts Cutanés Immunocompétents; Timbre Transdermique À Microaiguilles

$677,026

Comprendre la complexité du domaine lipidique cutané

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Pouliot, Roxane

$252,000

Comprendre la complexité du domaine lipidique cutané

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Pouliot, Roxane

$32,000

Étude de l'impact de l'innervation cutanée dans le Psoriasis

Co-investigatorCIHR2017Project Grant

Principal investigators: Berthod, François

Keywords: Cellules Dendritiques; Cellules Endothéliales; Génie Tissulaire; Innervation Sensorielle; Kératinocytes; Migration Axonale; Neurones; Neuropeptides; Peau; Psoriasis

$719,100

Substituted phenyl alkylureas as new potent antipsoriatic drugs: Mechanism of action and structure-activity relationships

Co-investigatorCIHR2015Operating Grant

Principal investigators: C.-Gaudreault, René

Keywords: Drugs; Mechanism Of Action; Molecular Pharmacology; Psoriasis; Psoriasis Mode

$623,533

Scanning electron microscope with energy dispersive X-ray spectroscopy for studies in regenerative medecine

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Laroche, Gaétan

$150,000

Comprendre le rôle des cellules immunitaires dans le psoriasis grâce au génie tissulaire

Nominated PICIHR2013Operating Grant

Principal investigators: Pouliot, Roxane

Keywords: Différenciation Cellulaire; Greffe; Génie Tissulaire; Immunologie; Peau; Peau Reconstruite; Psoriasis; Substituts Pathologiques

$555,672

FTIR imaging system for advanced materials characterization

Co-investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Laroche, Gaétan

$146,782

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Médecine
Surgery
Chirurgie
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Nicolas Flamand

Médecine

10 shared papers, latest 2026

Julie Fradette

Surgery

4 shared papers, latest 2022

Davide Brambilla

Faculty

4 shared papers, latest 2026

Vincenzo Di Marzo

Faculty

2 shared papers, latest 2021

Lucie Germain

Chirurgie

1 shared papers, latest 2013

Francois Gros-Louis

Faculty

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Génie Tissulaire Dear Professor Pouliot, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Alteration of epidermal lipid metabolism by 2-linoleoylglycerol in a 3D skin model." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Nouvelles options thérapeutiques pour les patients atteints de psoriasis" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]