Daniel Lajeunesse

Research

Not Applicable.

Latest papers

Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts.
Arthritis research & therapy · 2017 · senior author
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.
Annals of the rheumatic diseases · 2015
Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity.
Bone · 2014 · senior author

All 16 publications

Latest funding

Rôle of Prohibitins and SUMOylation in Osteoarthritis Pathogenesis
CIHR · 2017 · Co-investigator
$933,300
Role of Prohibitins and SUMOylation in OA pathogenesis
CIHR · 2016 · Co-investigator
$100,000
MD/PhD Program Grant (starting 2014-15)
CIHR · 2014 · Nominated PI
$132,000

All 6 grants and awards

16 publications.

01

Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts.

Abed É, Delalandre A, Lajeunesse D

Arthritis research & therapy2017Senior author

DOI: 10.1186/s13075-017-1365-2 PMID: 28666466

02

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.

Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M

Annals of the rheumatic diseases2015

DOI: 10.1136/annrheumdis-2014-205743 PMID: 25573665

03

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity.

Abed É, Couchourel D, Delalandre A, Duval N, Pelletier JP, Martel-Pelletier J, Lajeunesse D

Bone2014Senior author

DOI: 10.1016/j.bone.2013.10.020 PMID: 24184155

04

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium.

Pelletier JP, Kapoor M, Fahmi H, Lajeunesse D, Blesius A, Maillet J, Martel-Pelletier J

Annals of the rheumatic diseases2013

DOI: 10.1136/annrheumdis-2012-201710 PMID: 23065732

05

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts.

Chan TF, Couchourel D, Abed E, Delalandre A, Duval N, Lajeunesse D

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011Senior author

DOI: 10.1002/jbmr.358 PMID: 21312269

06

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis.

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H

Nature reviews. Rheumatology2011

DOI: 10.1038/nrrheum.2010.196 PMID: 21119608

07

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Kwan Tat S, Lajeunesse D, Pelletier JP, Martel-Pelletier J

Best practice & research. Clinical rheumatology2010

DOI: 10.1016/j.berh.2009.08.004 PMID: 20129200

08

Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression.

Mutabaruka MS, Aoulad Aissa M, Delalandre A, Lavigne M, Lajeunesse D

Arthritis research & therapy2010Senior author

DOI: 10.1186/ar2925 PMID: 20141628

09

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.

Kwan Tat S, Amiable N, Pelletier JP, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J

Rheumatology (Oxford, England)2009

DOI: 10.1093/rheumatology/kep300 PMID: 19762475

10

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.

Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C

Bone2009

DOI: 10.1016/j.bone.2009.02.015 PMID: 19264156

Rôle of Prohibitins and SUMOylation in Osteoarthritis Pathogenesis

Co-investigatorCIHR2017Project Grant

Principal investigators: Moreau, Alain

Keywords: Articular Chondrocytes; Expression Profiling; Knee/Hip Osteoarthritis; Osteoblasts; Phb1; Phb2; Proteomics; Str/Ort Mice; Sumoylation; Transcription Factor Pitx1

$933,300

Role of Prohibitins and SUMOylation in OA pathogenesis

Co-investigatorCIHR2016Project Grant

Principal investigators: Moreau, Alain

Keywords: Articular Chondrocytes; Expression Profiling; Knee/Hip Osteoarthritis; Osteoblasts; Phb1; Phb2; Proteomics; Str/Ort Mice; Sumoylation; Transcription Factor Pitx1

$100,000

MD/PhD Program Grant (starting 2014-15)

Nominated PICIHR2014CIHR MD/PhD Program Grants

Principal investigators: Lajeunesse, Daniel

$132,000

MD/PhD Program Grant (starting in 2013-14)

Nominated PICIHR2013CIHR MD/PhD Program Grants

Principal investigators: Lajeunesse, Daniel

Keywords: .; Not Applicable.

$132,000

Mechanisms involved in abnormal differentiation of osteogenic mesenchymal stem cells in osteoarthritis

Nominated PICIHR2011Operating Grant

Principal investigators: Lajeunesse, Daniel

Keywords: Adipocytes; Human Mesenchymal Stem Cells; Leptin; Osteoblasts; Str/Ort Mouse; Wnt Pathway

$472,023

Subvention de formation des IRSC en évaluation et traitement des troubles de la mobilité et de la posture (Programme MENTOR)

Co-investigatorCIHR2008Training Grant

Principal investigators: Labelle, Hubert B

Keywords: Appliquée; Apprentissage Actif; Arthrose; Cliniciens-Chercheurs; Compétences; Cycles Supérieurs; Déficits Neuromoteurs; Déformations; Fondamentale; Formation; Mentorat; Multidisciplinaire; Postdoctorat; Recherche; Recherche Clinique; Rigueur; Stagiaires; Transfert Et Application Des Connaissances; Traumatismes; Travail D'Équipe; Éthique; Évaluative

$1,050,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Orthopedics
Surgery
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Johanne Martel-Pelletier

Medicine

12 shared papers, latest 2015

Hassan Fahmi

Medicine

6 shared papers, latest 2015

Mohit Kapoor

Medicine

3 shared papers, latest 2015

Mohit Kapoor

Surgery

3 shared papers, latest 2015

Mohit Kapoor

Orthopedics

1 shared papers, latest 2015

Rajiv Gandhi

Orthopedics

1 shared papers, latest 2015

Peter Roughley

Faculty

1 shared papers, latest 2015

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Applying for

Paper to mention

Subject: Prospective PhD student: Not Applicable. Dear Professor Lajeunesse, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts." (2017), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Daniel Lajeunesse

Research

Latest papers

Latest funding

Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts.

PPAR&#x3b3; deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/&#x3b2;-catenin activity.

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1&#x3b2; in the synovium.

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts.

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis.

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression.

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.

Rôle of Prohibitins and SUMOylation in Osteoarthritis Pathogenesis

Role of Prohibitins and SUMOylation in OA pathogenesis

MD/PhD Program Grant (starting 2014-15)

MD/PhD Program Grant (starting in 2013-14)

Mechanisms involved in abnormal differentiation of osteogenic mesenchymal stem cells in osteoarthritis

Subvention de formation des IRSC en évaluation et traitement des troubles de la mobilité et de la posture (Programme MENTOR)

Frequent collaborators

Johanne Martel-Pelletier

Hassan Fahmi

Mohit Kapoor

Mohit Kapoor

Mohit Kapoor

Rajiv Gandhi

Peter Roughley

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity.

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium.