Gilbert Bernier, Université de Montréal

Research

Angiogenesis Dand5 Macular Edema Retinal Diseases Alzheimer'S Disease Chromatin Gene Expression Induced Pluripotent Stem Cells

Latest papers

BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication.
The Journal of biological chemistry · 2026 · senior author
Modeling Late-Onset Sporadic Alzheimer's Disease Using Patient-Derived Cells: A Review.
Neurology international · 2026 · senior author
Pharmaceutical inhibition of the Chk2 kinase mitigates cone photoreceptor degeneration in an iPSC model of Bardet-Biedl syndrome.
iScience · 2025 · senior author

All 22 publications

Latest funding

Études génétiques et moléculaires de la fonction des Polycomb dans la formation et le maintien de la stabilité de l'hétérochromatine
NSERC · 2023 · Principal investigator
$90,000
Role of COCO/Dand5 in visual function and assessment of its therapeutic potential for ocular pathologies.
CIHR · 2022 · Principal investigator
$699,975
Étude des mécanismes de déstabilisation du génome dans le vieillissement normal et pathologique
NSERC · 2017 · Principal investigator
$168,000

All 10 grants and awards

22 publications.

01

BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication.

Hanna R, Deneault E, Bernier G

The Journal of biological chemistry2026Senior author

DOI: 10.1016/j.jbc.2026.111172 PMID: 41570993

02

Modeling Late-Onset Sporadic Alzheimer's Disease Using Patient-Derived Cells: A Review.

Katbe A, Diagne I, Bernier G

Neurology international2026Senior author

DOI: 10.3390/neurolint18010017 PMID: 41591091

03

Pharmaceutical inhibition of the Chk2 kinase mitigates cone photoreceptor degeneration in an iPSC model of Bardet-Biedl syndrome.

Barabino A, Katbe A, Hanna R, Freedman BS, Bernier G

iScience2025Senior author

DOI: 10.1016/j.isci.2025.112130 PMID: 40151639

04

Molecular characterization and sub-retinal transplantation of hypoimmunogenic human retinal sheets in a minipig model of severe photoreceptor degeneration.

Barabino A, Mellal K, Hamam R, Polosa A, Griffith M, Bouchard JF, Kalevar A, Hanna R, Bernier G

Development (Cambridge, England)2024Senior author

DOI: 10.1242/dev.203071 PMID: 39633598

05

Alzheimer's disease: a tale of two diseases?

Nardini E, Hogan R, Flamier A, Bernier G

Neural regeneration research2021Senior author

DOI: 10.4103/1673-5374.308070 PMID: 33642366

06

G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer's disease.

Hanna R, Flamier A, Barabino A, Bernier G

Nature communications2021Senior author

DOI: 10.1038/s41467-021-22129-9 PMID: 33758195

07

COCO/DAND5 inhibits developmental and pathological ocular angiogenesis.

Popovic N, Hooker E, Barabino A, Flamier A, Provost F, Buscarlet M, Bernier G, Larrivée B

EMBO molecular medicine2021

DOI: 10.15252/emmm.202012005 PMID: 33587337

08

The Role of BMI1 in Late-Onset Sporadic Alzheimer's Disease.

Hogan R, Flamier A, Nardini E, Bernier G

Genes2020Senior author

DOI: 10.3390/genes11070825 PMID: 32708145

09

Deregulation of Neuro-Developmental Genes and Primary Cilium Cytoskeleton Anomalies in iPSC Retinal Sheets from Human Syndromic Ciliopathies.

Barabino A, Flamier A, Hanna R, Héon E, Freedman BS, Bernier G

Stem cell reports2020Senior author

DOI: 10.1016/j.stemcr.2020.02.005 PMID: 32160518

10

Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme.

Flamier A, Abdouh M, Hamam R, Barabino A, Patel N, Gao A, Hanna R, Bernier G

NPJ precision oncology2020Senior author

DOI: 10.1038/s41698-019-0106-1 PMID: 31934644

Études génétiques et moléculaires de la fonction des Polycomb dans la formation et le maintien de la stabilité de l'hétérochromatine

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Bernier, Gilbert

Keywords: Cellules souches; ChIP-seq; CRISPR; G-quadrupexes; Hétérochromatine; Neurones; Polycomb; RNA-seq; Séparation des phases; Stabilité du génome

$90,000

Role of COCO/Dand5 in visual function and assessment of its therapeutic potential for ocular pathologies.

Principal investigatorCIHR2022Project Grant

Principal investigators: Larrivee, Bruno; Bernier, Gilbert

Keywords: Angiogenesis; Dand5; Macular Edema; Retinal Diseases

$699,975

Étude des mécanismes de déstabilisation du génome dans le vieillissement normal et pathologique

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Bernier, Gilbert

$168,000

Disease mechanisms and targeted therapy for sporadic Alzheimer's disease

Nominated PICIHR2016Project Grant

Principal investigators: Bernier, Gilbert

Keywords: Alzheimer'S Disease; Chromatin; Gene Expression; Induced Pluripotent Stem Cells; Neurons; Polycomb Group Gene; Small Molecule; Therapy

$100,000

Evaluation of the anti-angiogenic and neuroprotective effects of the BMP antagonist COCO for the treatment of neovascular ocular pathologies.

Co-investigatorCIHR2016Project Grant

Principal investigators: Larrivee, Bruno

Keywords: Age-Related Macular Degeneration; Anti-Angiogenic Therapies; Experimental Models Of Eye Disease; Mechanisms Of Angiogenesis; Neuroprotection; Retinopathy Of Prematurity; Vascular Development

$573,375

Études génétiques du développement de la rétine et du cerveau chez la souris

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Bernier, Gilbert

$140,000

Les Cellules Souches : Mythes, Controverses et Réalité

Co-investigatorCIHR2011CIHR Café Scientifique Program

Principal investigators: Roy, Denis-Claude

Keywords: Cadre Règlementaire; Café Scientifique; Cellules Souches; Cellules Souches Embryonnaires; Enjeux Éthiques; Greffe De Cellules Souches; Immunothérapie Du Cancer; Médecine Régénérative; Réparation Tissulaire; Thérapie Cellulaire

$3,000

Génétique développement et des maladies de la rétine chez les mammifères

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Bernier, Gilbert

$150,000

Production de modèles animaux pour l'étude des rétinopathies et neuropathies humaines

Principal investigatorNSERC2006Discovery Grants Program - Individual

Principal investigators: Bernier, Gilbert

$35,000

Études génétiques du développement de la rétine chez la souris: isolation de nouveaux gènes et production de modèles animaux

Principal investigatorNSERC2002Discovery Grants Program - Individual

Principal investigators: Bernier, Gilbert

$152,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurosciences
Pharmacologie - Physiologie
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Anthony Flamier

Faculty

5 shared papers, latest 2021

Francis Rodier

Faculty

1 shared papers, latest 2009

Adriana Di Polo

Neurosciences

1 shared papers, latest 2013

May Griffith

Pharmacologie - Physiologie

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Angiogenesis Dear Professor Bernier, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Études génétiques et moléculaires de la fonction des Polycomb dans la formation et le maintien de la stabilité de l'hétérochromatine" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]