Faculty profile

Adriana Di Polo

ResearcherNeurosciencesUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Adriana Di Polo

Researcher

Neurosciences

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
22 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (9 CIHR, 1 NSERC), most recently in 2026.
Supervised 1 trainee who won CIHR awards, most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Glaucoma Retinal Ganglion Cell Retina Cell Biology Mechanisms Of Disease Dendrite Regeneration Insulin Signaling Mammalian Target Of Rapamycin

Latest papers

Breaking the barrier: Endothelial mitochondrial stress drives vascular compromise in glaucoma.
Neural regeneration research · 2026 · senior author
Vascular regeneration and blood flow recovery in glaucoma.
Frontiers in cell and developmental biology · 2026 · senior author
Reply.
Ophthalmology science · 2026

All 58 publications

Latest funding

Mechanisms driving neuronal regeneration in glaucoma: novel strategies to promote vision restoration
CIHR · 2026 · Nominated PI
$1,185,750
Neurovascular repair in glaucoma: novel mechanisms and therapeutic targets
CIHR · 2024 · Nominated PI
$849,150
Live two-photon calcium imaging in retinal ganglion cells: characterization of pathological changes and mechanisms in glaucoma.
CIHR · 2020 · Supervisor
$135,000

All 11 grants and awards

58 publications.

Breaking the barrier: Endothelial mitochondrial stress drives vascular compromise in glaucoma.

Vidal-Paredes IA, Quintero H, Di Polo A

Neural regeneration research2026Senior author

DOI: 10.4103/nrr.nrr-d-26-00345 PMID: 42608767

Vascular regeneration and blood flow recovery in glaucoma.

Waxman S, Di Polo A

Frontiers in cell and developmental biology2026Senior author

DOI: 10.3389/fcell.2026.1851815 PMID: 42317267

Reply.

Saludares M, Wennberg-Smith Z, Beykin G, Khatib TZ, Nunez M, Wang Q, Di Polo A, Goldberg JL

Ophthalmology science2026

DOI: 10.1016/j.xops.2026.101173 PMID: 42100597

Blood flow patterns in mice are regulated by interpericyte tunneling nanotubes connecting functionally-opposite neuronal areas.

Gardner-Russell J, Haddara M, Wang AYM, Villafranca-Baughman D, van Wijngaarden P, Bui B, Martin KR, Di Polo A, Alarcon-Martinez L

Nature communications2026

DOI: 10.1038/s41467-026-71804-2 PMID: 41974735

Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.

Dunn M, Cull G, Reynaud J, Gardiner SK, Di Polo A, Fortune B

Investigative ophthalmology & visual science2026

DOI: 10.1167/iovs.67.2.24 PMID: 41665300

A Phase I Randomized Trial of Topical Insulin for Glaucoma: Safety and Efficacy Outcomes.

Saludares M, Wennberg-Smith Z, Beykin G, Khatib TZ, Nunez M, Wang Q, Di Polo A, Goldberg JL

Ophthalmology science2026

DOI: 10.1016/j.xops.2025.101032 PMID: 41584099

Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.

Cueva Vargas JL, Belforte N, Vidal-Paredes IA, Dotigny F, Vande Velde C, Quintero H, Di Polo A

Molecular therapy : the journal of the American Society of Gene Therapy2026Senior author

DOI: 10.1016/j.ymthe.2025.09.037 PMID: 40994007

Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies.

Ward EL, Benowitz L, Brunner TM, Bu G, Cayouette M, Canto-Soler V, Dá Mesquita S, Di Polo A, DiAntonio A, Duan X, Goldberg JL, He Z, Hu Y, Liddelow SA, La Torre A, Margeta M, Quintana F, Shekhar K, Stevens B, Temple S, Venkatesh H, Welsbie D, Flanagan JG

Molecular neurodegeneration2025

DOI: 10.1186/s13024-025-00858-5 PMID: 41088409

Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.

Cueva-Vargas JL, Belforte N, Vidal-Paredes IA, Dotigny F, Vande Velde C, Quintero H, Di Polo A

bioRxiv : the preprint server for biology2025Senior author

DOI: 10.1101/2024.12.21.629919 PMID: 39975311

Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation.

Shiga Y, Rangel Olguin AG, El Hajji S, Belforte N, Quintero H, Dotigny F, Alarcon-Martinez L, Krishnaswamy A, Di Polo A

Cell reports. Medicine2024Senior author

DOI: 10.1016/j.xcrm.2024.101839 PMID: 39615485

Mechanisms driving neuronal regeneration in glaucoma: novel strategies to promote vision restoration

Nominated PICIHR2026Project Grant

Principal investigators: Di Polo, Adriana

Keywords: Glaucoma; Glucose Metabolism; Insulin; Mitochondrial Dysfunction; Retinal Ganglion Cell Regeneration

$1,185,750

Neurovascular repair in glaucoma: novel mechanisms and therapeutic targets

Nominated PICIHR2024Project Grant

Principal investigators: Di Polo, Adriana

Keywords: Cell Biology; Glaucoma; Mechanisms Of Disease; Retina; Retinal Ganglion Cell; Vascular Function

$849,150

Live two-photon calcium imaging in retinal ganglion cells: characterization of pathological changes and mechanisms in glaucoma.

SupervisorCIHR2020CIHR Fellowship

Principal investigators: Shiga, Yukihiro

Keywords: Glaucoma; In Vivo Imaging; Retinal Ganglion Cell

$135,000

Neural repair in glaucoma: the role of insulin signaling

Nominated PICIHR2019Project Grant

Principal investigators: Di Polo, Adriana

Keywords: Cell Biology; Dendrite Regeneration; Glaucoma; Insulin Signaling; Mammalian Target Of Rapamycin; Mechanisms Of Disease; Neuronal Repair; Pre-Clinical Studies; Retina; Retinal Ganglion Cell

$889,314

Neural repair in glaucoma: the role of insulin signaling

Nominated PICIHR2018Project Grant

Principal investigators: Di Polo, Adriana

Keywords: Cell Biology; Dendrite Regeneration; Glaucoma; Insulin Signaling; Mammalian Target Of Rapamycin; Mechanisms Of Disease; Neuronal Repair; Pre-Clinical Studies; Retina; Retinal Ganglion Cell

$100,000

Canada Research Chair - Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Di Polo, Adriana

Keywords: Crc

$1,400,000

Tau: a novel target to prevent early neuronal dysfunction and death in glaucoma.

Nominated PICIHR2016Project Grant

Principal investigators: Di Polo, Adriana

Keywords: Alzheimer'S Disease; Dendrite Pathology; Glaucoma; Optic Nerve Pathology; Retina; Retinal Degeneration; Retinal Ganglion Cell; Tau

$895,050

Molecular mechanisms of retinal ganglion cell dendrite degeneration.

Nominated PICIHR2012Operating Grant

Principal investigators: Di Polo, Adriana

Keywords: Animal Models; Apoptosis; Dendrite; Glaucoma; Mammalian Target Of Rapamycin (Mtor); Neurodegeneration; Retinal Ganglion Cell; Synapse; Tumor Necrosis Factor-Alpha (Tnfalpha); Visual Function

$715,845

CIHR Team Grant in "Saving Vision in Glaucoma: Novel Mechanisms and Therapeutic Targets."

Nominated PICIHR2010Team Grant: Vision, Hearing and Communication Disorders

Principal investigators: Di Polo, Adriana; Barker, Philip A; Bowie, Derek

Keywords: Glaucoma; Glutamate Receptors; Mueller Glia; Nuclear Factor Kappa B; Retinal Ganglion Cell; Tumor Necrosis Factor

$1,496,160

CIHR Team Grant in "Saving Vision in Glaucoma: Novel Mechanisms and Therapeutic Targets."

Nominated PICIHR2009Team Grant: Vision, Hearing and Communication Disorders - LOI

Principal investigators: Di Polo, Adriana; Barker, Philip A; Bowie, Derek

Keywords: Glaucoma; Glutamate Receptors; Mueller Glia; Nuclear Factor Kappa B; Retinal Ganglion Cell; Tumor Necrosis Factor

$5,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Adriana Di Polo

Research

Latest papers

Latest funding

Breaking the barrier: Endothelial mitochondrial stress drives vascular compromise in glaucoma.

Vascular regeneration and blood flow recovery in glaucoma.

Reply.

Blood flow patterns in mice are regulated by interpericyte tunneling nanotubes connecting functionally-opposite neuronal areas.

Microvascular Volume Loss Exceeds Nerve Fiber Layer but Not Neuroretinal Rim Tissue Loss During Progression of Nonhuman Primate Experimental Glaucoma.

A Phase I Randomized Trial of Topical Insulin for Glaucoma: Safety and Efficacy Outcomes.

Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.

Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies.

Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.

Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation.

Frequent collaborators

Pierre Lachapelle

Sylvain Chemtob

Pierre Hardy

Przemyslaw Sapieha

Derek Bowie

Przemyslaw Sapieha

Marie-Claude Robert

Alexandre Prat

Christine Vande Velde

Arjun Krishnaswamy

Gilbert Bernier

Pierre Drapeau

Sophie Tremblay

Elvire Vaucher

Christian Casanova

David Stellwagen

Gregor Andelfinger

Nathalie Arbour

Michel Cayouette

Cheryl Wellington