Janelle Drouin-Ouellet, Université de Montréal

Research

Dopaminergic Neurons Induced Neurons Induced Pluripotent Stem Cells Mitochondrial Dysfunction Mitophagy Parkinson'S Disease Crc

Latest papers

Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons.
Cellular & molecular biology letters · 2026
Investigating the ageing-Parkinson's disease nexus: standardisation of in vitro models and techniques by the PD-AGE network.
NPJ Parkinson's disease · 2025
Mitochondrial complex I deficiency and Parkinson disease.
Nature reviews. Neuroscience · 2023 · first author

All 13 publications

Latest funding

Développement de stratégies de reprogrammation neuronale directe à partir de cultures d'astrocytes humains pour le traitement de la maladie d'Alzheimer.
CIHR · 2025 · Supervisor
$120,000
Investigation of the heterogeneity of mitochondrial dysfunction in idiopathic Parkinson's disease using induced neurons derived from patients
CIHR · 2022 · Nominated PI
$100,000
A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders
SSHRC · 2022 · Co-investigator
$8,000,000

All 8 grants and awards

13 publications.

01

Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons.

Danics L, Muralidharan C, Varga Á, Rezeli M, Gil J, Abbas AA, Pap Á, Park AS, Cserhalmi M, Legault EM, Sőth Á, Jamniczky D, Zsoldos R, Barker RA, Róna G, Drouin-Ouellet J, Markó-Varga G, Darula Z, Pircs K

Cellular & molecular biology letters2026

DOI: 10.1186/s11658-026-00948-2 PMID: 42231151

02

Investigating the ageing-Parkinson's disease nexus: standardisation of in vitro models and techniques by the PD-AGE network.

Bury AG, Olejnik A, Tocco C, Saurat N, Stephen E, Hockemeyer D, Schwamborn JC, Studer L, Mastroberardino PG, Bolognin S, Kunath T, Korolchuk VI, Drouin-Ouellet J, Mortiboys H

NPJ Parkinson's disease2025

DOI: 10.1038/s41531-025-01137-2 PMID: 41068112

03

Mitochondrial complex I deficiency and Parkinson disease.

Drouin-Ouellet J

Nature reviews. Neuroscience2023First author

DOI: 10.1038/s41583-023-00676-y PMID: 36697768

04

Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.

Drouin-Ouellet J, Legault EM, Nilsson F, Pircs K, Bouquety J, Petit F, Shrigley S, Birtele M, Pereira M, Storm P, Sharma Y, Bruzelius A, Vuono R, Kele M, Stoker TB, Ottosson DR, Falk A, Jakobsson J, Barker RA, Parmar M

Stem cell reports2022First author

DOI: 10.1016/j.stemcr.2022.08.010 PMID: 36150382

05

The 2022 International Society for Stem Cell Research (ISSCR) Annual Meeting: Celebrating 20 Years of Achievements.

Drouin-Ouellet J, Li D, Lu YR, Echegaray CV

Cellular reprogramming2022First author

DOI: 10.1089/cell.2022.0105 PMID: 36219715

06

Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming.

Legault EM, Bouquety J, Drouin-Ouellet J

Cellular reprogramming2022Senior author

DOI: 10.1089/cell.2021.0172 PMID: 35749150

07

Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease.

Pircs K, Drouin-Ouellet J, Horváth V, Gil J, Rezeli M, Garza R, Grassi DA, Sharma Y, St-Amour I, Harris K, Jönsson ME, Johansson PA, Vuono R, Fazal SV, Stoker T, Hersbach BA, Sharma K, Lagerwall J, Lagerström S, Storm P, Hébert SS, Marko-Varga G, Parmar M, Barker RA, Jakobsson J

Brain : a journal of neurology2022

DOI: 10.1093/brain/awab473 PMID: 34936701

08

An Improved Method to Generate Human Induced Astrocytes.

Drouin-Ouellet J

Cellular reprogramming2022First author

DOI: 10.1089/cell.2022.0076 PMID: 35969675

09

Reprogramming Human Adult Fibroblasts into GABAergic Interneurons.

Bruzelius A, Kidnapillai S, Drouin-Ouellet J, Stoker T, Barker RA, Rylander Ottosson D

Cells2021

DOI: 10.3390/cells10123450 PMID: 34943958

10

A quantitative model of cellular decision making in direct neuronal reprogramming.

Merlevede A, Legault EM, Drugge V, Barker RA, Drouin-Ouellet J, Olariu V

Scientific reports2021

DOI: 10.1038/s41598-021-81089-8 PMID: 33452356

Développement de stratégies de reprogrammation neuronale directe à partir de cultures d'astrocytes humains pour le traitement de la maladie d'Alzheimer.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Armanville, Sandrine

Keywords: Astrocytes; Facteurs De Transcription; Maladie D'Alzheimer; Maladies Neurodégénératives; Maladies Neurologiques; Reprogrammation Cellulaire Directe; Réseau De Régulation Des Gènes

$120,000

Investigation of the heterogeneity of mitochondrial dysfunction in idiopathic Parkinson's disease using induced neurons derived from patients

Nominated PICIHR2022Project Grant - Priority Announcement: Aging

Principal investigators: Drouin-Ouellet, Janelle

Keywords: Dopaminergic Neurons; Induced Neurons; Induced Pluripotent Stem Cells; Mitochondrial Dysfunction; Mitophagy; Parkinson'S Disease

$100,000

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Schuurmans, Carol

Keywords: neurodegenerative disease,; Alzheimer's disease; direct neuronal reprogramming; transcription factors; gene regulatory networks ; computer-guided design; nanoparticles; epigenomics ; neurological disorders; self-amplifying RNA; bacteriophage; astrocytes; stroke; epilepsy; focused ultrasound

$8,000,000

Maturation of microRNAs targeting alpha-synuclein

Co-investigatorCIHR2022Project Grant

Principal investigators: Legault, Pascale

Keywords: Alpha-Synuclein; Control Of Gene Expression; Ipsc Lines; Microrna Maturation; Micrornas; Mouse Models; Primary Dopaminergic Neurons; Riboproteomics; Rna-Protein Interactions; Transcriptomics

$1,021,275

Mechanisms of direct dopaminergic neuronal reprogramming to study aging

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Drouin-Ouellet, Janelle

$120,000

Mechanisms of direct dopaminergic neuronal reprogramming to study aging

Principal investigatorNSERC2021Discovery Launch Supplement

Principal investigators: Drouin-Ouellet, Janelle

$12,500

Highly versatile benchtop Flow Cytometry Analyzer

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Brambilla, Davide

$135,662

Canada Research Chairs - Tier 2

Nominated PICIHR2019Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Drouin-Ouellet, Janelle

Keywords: Crc

$600,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurology and Neurosurgery
Psychiatrie et de neurosciences
Neurosciences
Clinical Neurosciences
Other

1 shared papers, latest 2020

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A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Dopaminergic Neurons Dear Professor Drouin-Ouellet, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Phosphoproteomic profiling reveals post-translational dysregulation in Huntington's disease patient-derived neurons." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Investigation of the heterogeneity of mitochondrial dysfunction in idiopathic Parkinson's disease using induced neurons derived from patients" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]