Thomas Durcan, McGill University

Research

Induced Pluripotent Stem Cells Minibrains Organoids Parkinson'S Disease Propagation Seeding Synuclein

Latest papers

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing.
Neuroscience · 2020
Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication.
Neurobiology of disease · 2020
The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.
Journal of Parkinson's disease · 2020

All 3 publications

Latest funding

Uniting Canada's Leukodystrophy Community: The CARELeuko Mandate to Drive Collaboration and Accelerate Research and Care
CIHR · 2025 · Co-investigator
$20,000
Role of Mitochondrial Import and Processing of PINK1 in Parkinson Disease
CIHR · 2024 · Co-investigator
$1,101,600
Advancing POP inhibitors as potential Parkinson's disease therapeutics
CIHR · 2024 · Co-investigator
$1,067,176

All 8 grants and awards

3 publications.

01

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing.

Thiry L, Hamel R, Pluchino S, Durcan T, Stifani S

Neuroscience2020

DOI: 10.1016/j.neuroscience.2020.04.041 PMID: 32380268

02

Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication.

Siddu A, David LS, Lauinger N, Chen X, Saint-Pierre M, Alpaugh M, Durcan T, Cicchetti F

Neurobiology of disease2020

DOI: 10.1016/j.nbd.2020.105042 PMID: 32798729

03

The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.

Gan-Or Z, Rao T, Leveille E, Degroot C, Chouinard S, Cicchetti F, Dagher A, Das S, Desautels A, Drouin-Ouellet J, Durcan T, Gagnon JF, Genge A, Karamchandani J, Lafontaine AL, Sun SLW, Langlois M, Levesque M, Melmed C, Panisset M, Parent M, Poline JB, Postuma RB, Pourcher E, Rouleau GA, Sharp M, Monchi O, Dupré N, Fon EA

Journal of Parkinson's disease2020

DOI: 10.3233/jpd-191775 PMID: 31868683

Uniting Canada's Leukodystrophy Community: The CARELeuko Mandate to Drive Collaboration and Accelerate Research and Care

Co-investigatorCIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Bernard, Geneviève

Keywords: Collaborative Care; Genetic Leukoencephalopathies; Knowledge Translation; Leukodystrophies; Patient Engagement; Rare Diseases; Research Symposium

$20,000

Role of Mitochondrial Import and Processing of PINK1 in Parkinson Disease

Co-investigatorCIHR2024Project Grant

Principal investigators: Fon, Edward A

Keywords: Ipscs; Mitochondria; Mitophagy; Neurodegeneration; Parkin; Parkinson Disease; Pink1; Ubiquitin

$1,101,600

Advancing POP inhibitors as potential Parkinson's disease therapeutics

Co-investigatorCIHR2024Project Grant

Principal investigators: Moitessier, Nicolas R

Keywords: Alpha-Synuclein Aggregation; Disease Modifying Therapy; Parkinson'S Disease; Therapeutics

$1,067,176

TRIDENT: TRanslational Initiative to DE-risk NeuroTherapeutics

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Menon, Ravi

Keywords: cognition; drug discovery; mouse models; marmoset; organoids; imaging; open science; neurodegenerative disease; neurochemistry; neural circuits; sex differences

$8,000,000

EPRS1-related leukodystrophy: generation of a representative cellular model to study disease pathophysiology and potential therapeutic avenues using patient-derived iPSCs

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Chapleau, Alexandra K

Keywords: Aminoacyl Trna Synthetases; Cell Culture; Disease Modelling; Eprs1; Genetic Engineering; Hypomyelination; Induced Pluripotent Stem Cells (Ipscs); Leukodystrophy; Oligodendrocytes; Translation

$105,000

Investigating microglial contributions to inflammation in Parkinson's disease using brain-like organoids

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Dorion, Marie-France

Keywords: Ipsc; Microglia; Neuroinflammation; Organoid; Parkinson'S Disease

$105,000

Unravelling the complex process of synuclein seeding and propagation with human stem cell derived models

Nominated PICIHR2019Project Grant

Principal investigators: Durcan, Thomas M

Keywords: Induced Pluripotent Stem Cells; Minibrains; Organoids; Parkinson'S Disease; Propagation; Seeding; Synuclein

$726,750

Transforming the development and dissemination of expertise, knowledge and technologies in neuroscience through scientific platforms.

Co-investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Paquet, Marie-Eve

Keywords: Best Practices; Brain Research; Career Paths; Collaborative Models And Infrastructure; International Brain Initiatives; Neurotechnologies; Scientific Platforms; Shared Facilities; Technology Dissemination; Train The Trainer

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurology and Neurosurgery
Psychiatrie et de neurosciences
Neurosciences
Clinical Neurosciences
Other

Applying for

Paper to mentionMention their CIHR grant from 2019

Subject: Prospective PhD student: Induced Pluripotent Stem Cells Dear Professor Durcan, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing." (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Unravelling the complex process of synuclein seeding and propagation with human stem cell derived models" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Thomas Durcan

Research

Latest papers

Latest funding

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing.

Beneficial effects of cysteamine in Thy1-&#x3b1;-Syn mice and induced pluripotent stem cells with a SNCA gene triplication.

The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.

Uniting Canada's Leukodystrophy Community: The CARELeuko Mandate to Drive Collaboration and Accelerate Research and Care

Role of Mitochondrial Import and Processing of PINK1 in Parkinson Disease

Advancing POP inhibitors as potential Parkinson's disease therapeutics

TRIDENT: TRanslational Initiative to DE-risk NeuroTherapeutics

EPRS1-related leukodystrophy: generation of a representative cellular model to study disease pathophysiology and potential therapeutic avenues using patient-derived iPSCs

Investigating microglial contributions to inflammation in Parkinson's disease using brain-like organoids

Unravelling the complex process of synuclein seeding and propagation with human stem cell derived models

Transforming the development and dissemination of expertise, knowledge and technologies in neuroscience through scientific platforms.

Frequent collaborators

Francesca Cicchetti

Janelle Drouin-Ouellet

Madeleine Sharp

Jean-Baptiste Poline

Jason Karamchandani

Jason Karamchandani

Michel Panisset

Martin Lévesque

Alain Dagher

Oury Monchi

Angela Genge

Stefano Stifani

Martin Parent

Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication.