Martin Sirois, Université de Montréal

Research

Inflammation Neutrophils Biomarkers Cell Sorter Confocal Microscopy Heart Failure Murine Hfpef Model Neutrophil Extracellular Traps

Latest papers

Initial Pre-Clinical Evaluation of the Augmented Ultra-Low Temperature Cryoablation Catheter for Ventricular Ablations.
Journal of cardiovascular electrophysiology · 2026
Greater TIMP-1 protein levels and neointimal formation represent sex-dependent cellular events limiting aortic vessel expansion in female rats.
IUBMB life · 2024
SPECT imaging of pulmonary vascular disease in bleomycin-induced lung fibrosis using a vascular endothelium tracer.
Respiratory research · 2021

All 7 publications

Latest funding

Neutrophil extracellular traps (NETs) are major actors in heart failure with preserved ejection fraction
CIHR · 2021 · Nominated PI
$699,976
Differential agonistic activities of angiopoietins on neutrophils
CIHR · 2014 · Nominated PI
$716,595
Agonistic activities of angiopoietins on neutrophils
CIHR · 2009 · Nominated PI
$565,973

All 3 grants and awards

7 publications.

01

Initial Pre-Clinical Evaluation of the Augmented Ultra-Low Temperature Cryoablation Catheter for Ventricular Ablations.

Dyrda K, Verma A, Dinov B, Fink T, Potter T, Raffa S, Sirois M, Clavet-Lanthier ME, Grigorov I, Pourfard P, Babkin A, Essebag V

Journal of cardiovascular electrophysiology2026

DOI: 10.1111/jce.70311 PMID: 41845587

02

Greater TIMP-1 protein levels and neointimal formation represent sex-dependent cellular events limiting aortic vessel expansion in female rats.

Al-Katat A, Boudreau L, Gagnon E, Assous I, Villeneuve L, Leblanc CA, Bergeron A, Sirois M, El-Hamamsy I, Calderone A

IUBMB life2024

DOI: 10.1002/iub.2916 PMID: 39264710

03

SPECT imaging of pulmonary vascular disease in bleomycin-induced lung fibrosis using a vascular endothelium tracer.

Harel F, Nguyen QT, Nsaibia MJ, Finnerty V, Morgan A, Sirois M, Villeneuve L, Calderone A, Bergeron A, Brochiero E, Tardif JC, Shi Y, Dupuis J

Respiratory research2021

DOI: 10.1186/s12931-021-01836-3 PMID: 34481508

04

The inflammation-resolution promoting molecule resolvin-D1 prevents atrial proarrhythmic remodelling in experimental right heart disease.

Hiram R, Xiong F, Naud P, Xiao J, Sirois M, Tanguay JF, Tardif JC, Nattel S

Cardiovascular research2021

DOI: 10.1093/cvr/cvaa186 PMID: 32866246

05

A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes' interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19.

Ding J, Hostallero DE, El Khili MR, Fonseca GJ, Milette S, Noorah N, Guay-Belzile M, Spicer J, Daneshtalab N, Sirois M, Tremblay K, Emad A, Rousseau S

PLoS computational biology2021

DOI: 10.1371/journal.pcbi.1008810 PMID: 33684134

06

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia.

Moreira LM, Takawale A, Hulsurkar M, Menassa DA, Antanaviciute A, Lahiri SK, Mehta N, Evans N, Psarros C, Robinson P, Sparrow AJ, Gillis MA, Ashley N, Naud P, Barallobre-Barreiro J, Theofilatos K, Lee A, Norris M, Clarke MV, Russell PK, Casadei B, Bhattacharya S, Zajac JD, Davey RA, Sirois M, Mead A, Simmons A, Mayr M, Sayeed R, Krasopoulos G, Redwood C, Channon KM, Tardif JC, Wehrens XHT, Nattel S, Reilly S

Nature2020

DOI: 10.1038/s41586-020-2890-8 PMID: 33149301

07

In Vivo Near-Infrared Fluorescence Imaging of Atherosclerosis Using Local Delivery of Novel Targeted Molecular Probes.

Bertrand MJ, Abran M, Maafi F, Busseuil D, Merlet N, Mihalache-Avram T, Geoffroy P, Tardif PL, Abulrob A, Arbabi-Ghahroudi M, Ni F, Sirois M, L'Allier PL, Rhéaume É, Lesage F, Tardif JC

Scientific reports2019

DOI: 10.1038/s41598-019-38970-4 PMID: 30804367

Neutrophil extracellular traps (NETs) are major actors in heart failure with preserved ejection fraction

Nominated PICIHR2021Project Grant

Principal investigators: Sirois, Martin G

Keywords: Biomarkers; Cell Sorter; Confocal Microscopy; Heart Failure; Inflammation; Murine Hfpef Model; Neutrophil Extracellular Traps; Neutrophils

$699,976

Differential agonistic activities of angiopoietins on neutrophils

Nominated PICIHR2014Operating Grant

Principal investigators: Sirois, Martin G

Keywords: Angiogenesis; Cell Biology; Cell Signaling; Cytokines / Inflammatory Mediators; Flow Cytometry; Growth Factors; Histology / Immunohistochemistry; Inflammation; Microparticles; Neutrophils

$716,595

Agonistic activities of angiopoietins on neutrophils

Nominated PICIHR2009Operating Grant

Principal investigators: Sirois, Martin G

Keywords: Angiopoietins; Cell Biology; Cell Signaling; Chemotactic Activities; Endothelial Cells; Facs; Growth Factors; Inflammation; Integrins; Neutrophils; Tie2 Receptor; Tyrosine Kinase

$565,973

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Research Centre
Chemical Engineering
Cellular and Molecular Medicine
Meakins-Christie Laboratories
Other

1 shared papers, latest 2026

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A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Inflammation Dear Professor Sirois, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Initial Pre-Clinical Evaluation of the Augmented Ultra-Low Temperature Cryoablation Catheter for Ventricular Ablations." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Neutrophil extracellular traps (NETs) are major actors in heart failure with preserved ejection fraction" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]