Faculty profile

Danielle Jacques

ResearcherImmunologie-Biologie CellulaireUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Danielle Jacques

Researcher

Immunologie-Biologie Cellulaire

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
13 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 NSERC, 2 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Cardiomyocytes Dépendance Du Sexe Hamsters Normaux Et Cardiomyopathiques Hypertrophie Et Défaillance Cardiaque Imagerie Par Résonance Magnétique (Irm)Ros Sodium Et Calcium Intracellulaire Supplément En Taurine

Latest papers

Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.
Pathophysiology : the official journal of the International Society for Pathophysiology · 2026 · senior author
Resting Cytosolic and Nuclear Reactive Oxygen Species (ROS) Are Regulated by the Basal Activity of ET-1 Receptors in Human Vascular Smooth Muscle Cells.
International journal of molecular sciences · 2026 · senior author
Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system.
Canadian journal of physiology and pharmacology · 2026 · senior author

All 56 publications

Latest funding

Rôle d'un supplément de taurine pour la prévention de la nécrose, de l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire.
CIHR · 2022 · Nominated PI
$830,025
Modulation of cytosolic and nuclear calcium in endocardial endothelium by endothelin-1. Modulation du calcium cytosolique et nucléaire par l'endothéline-1 au niveau de l'endothélium endocardique.
NSERC · 2017 · Principal investigator
$150,000
Role of ET-1 and Ang II induced cytosolic and nuclear ROS generation in nuclear T-tubules formation in hypertrophy and ageing of human vascular smooth muscle cells.
CIHR · 2012 · Co-investigator
$651,185

All 8 grants and awards

56 publications.

Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.

Bkaily G, Normand A, Jazzar A, Najibeddine H, Jacques D

Pathophysiology : the official journal of the International Society for Pathophysiology2026Senior author

DOI: 10.3390/pathophysiology33020037 PMID: 42347022

Resting Cytosolic and Nuclear Reactive Oxygen Species (ROS) Are Regulated by the Basal Activity of ET-1 Receptors in Human Vascular Smooth Muscle Cells.

Bkaily G, Semaan R, Jacques D

International journal of molecular sciences2026Senior author

DOI: 10.3390/ijms27062524 PMID: 41898389

Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system.

Bkaily G, Jazzar A, Jacques D

Canadian journal of physiology and pharmacology2026Senior author

DOI: 10.1139/cjpp-2025-0240 PMID: 41086444

Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System.

Bkaily G, Jazzar A, Abou-Aichi A, Jacques D

Biomedicines2025Senior author

DOI: 10.3390/biomedicines13081842 PMID: 40868096

In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner.

Jazzar A, Jacques D, Abou-Aichi A, Bkaily G

Pathophysiology : the official journal of the International Society for Pathophysiology2025

DOI: 10.3390/pathophysiology32010012 PMID: 40137469

Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent.

Bkaily G, Simon Y, Abou Abdallah J, Ouertane C, Essalhi A, Khalil A, Jacques D

Nutrients2024Senior author

DOI: 10.3390/nu16070946 PMID: 38612980

Taurine Prevents Angiotensin II-Induced Human Endocardial Endothelium Morphological Remodeling and the Increase in Cytosolic and Nuclear Calcium and ROS.

Jacques D, Bkaily G

Nutrients2024First author

DOI: 10.3390/nu16050745 PMID: 38474873

High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory.

Simon Y, Jacques D, Bkaily G

Canadian journal of physiology and pharmacology2023

DOI: 10.1139/cjpp-2023-0087 PMID: 37290125

Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System.

Bkaily G, Jacques D

International journal of molecular sciences2023Senior author

DOI: 10.3390/ijms24108803 PMID: 37240147

Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases.

Bkaily G, Jacques D

International journal of molecular sciences2023Senior author

DOI: 10.3390/ijms24031998 PMID: 36768314

Rôle d'un supplément de taurine pour la prévention de la nécrose, de l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire.

Nominated PICIHR2022Project Grant

Principal investigators: Jacques, Danielle; Bkaily, Ghassan

Keywords: Cardiomyocytes; Dépendance Du Sexe; Hamsters Normaux Et Cardiomyopathiques; Hypertrophie Et Défaillance Cardiaque; Imagerie Par Résonance Magnétique (Irm); Ros; Sodium Et Calcium Intracellulaire; Supplément En Taurine; Tomographie D'Émission Par Positron (Tep); Étude In Vivo

$830,025

Modulation of cytosolic and nuclear calcium in endocardial endothelium by endothelin-1. Modulation du calcium cytosolique et nucléaire par l'endothéline-1 au niveau de l'endothélium endocardique.

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Jacques, Danielle

$150,000

Role of ET-1 and Ang II induced cytosolic and nuclear ROS generation in nuclear T-tubules formation in hypertrophy and ageing of human vascular smooth muscle cells.

Co-investigatorCIHR2012Operating Grant

Principal investigators: Bkaily, Ghassan

Keywords: Calcium Homeostasis; Nuclear Membranes Receptors; Nuclear T-Tubules; Nuclear Transport; Pharmacology Of Nuclear Membranes Receptors; Vascular Aging; Vascular Hypertrophy

$651,185

Roles of sodium-hydrogen exchangers in the development of hereditary cardiomyopathy

Co-investigatorCIHR2011Operating Grant

Principal investigators: Bkaily, Ghassan

Keywords: Calcium Overload; Cardiomyopathy; Heart Failure; Hypertrophy; Hypotension; Nuclear Membranes Transport; Sodium Overload; Sodium-Hydrogen Exchanger

$663,327

Regulation of secretion of cardiac endocardial endothelial cells by neuropeptide Y. Régulation de la sécrétion des cellules endothéliales endocardiques par le neuropeptide Y.

Nominated PICIHR2010Operating Grant

Principal investigators: Jacques, Danielle

Keywords: Endocardial Endothelium; Endothelin-1; Hypertrophy; Left And Right Ventricles; Neuropeptide Y

$689,007

Modulation of nuclear T-tubules in endocardial endothelium by ET-1. Modulation des tubules-T nucléaires par l'ET-1 au niveau de l'endothelium endocardique

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Jacques, Danielle

$135,000

Modulation of cytosolic and nuclear calcium in endocardial endothelium by ET-1

Principal investigatorNSERC2003Discovery Grants Program - Individual

Principal investigators: Jacques, Danielle

$153,600

Modulation du ca2+ cytosolique et nucléaire de l`endothélium endocardique par l?T-1

Principal investigatorNSERC1999Discovery Grants Program - Individual

Principal investigators: Jacques, Danielle

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Cardiomyocytes Dear Professor Jacques, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Rôle d'un supplément de taurine pour la prévention de la nécrose, de l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire." (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Danielle Jacques

Research

Latest papers

Latest funding

Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.

Resting Cytosolic and Nuclear Reactive Oxygen Species (ROS) Are Regulated by the Basal Activity of ET-1 Receptors in Human Vascular Smooth Muscle Cells.

Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system.

Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System.

In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner.

Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent.

Taurine Prevents Angiotensin II-Induced Human Endocardial Endothelium Morphological Remodeling and the Increase in Cytosolic and Nuclear Calcium and ROS.

High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory.

Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System.

Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases.

Rôle d'un supplément de taurine pour la prévention de la nécrose, de l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire.

Modulation of cytosolic and nuclear calcium in endocardial endothelium by endothelin-1. Modulation du calcium cytosolique et nucléaire par l'endothéline-1 au niveau de l'endothélium endocardique.

Role of ET-1 and Ang II induced cytosolic and nuclear ROS generation in nuclear T-tubules formation in hypertrophy and ageing of human vascular smooth muscle cells.

Roles of sodium-hydrogen exchangers in the development of hereditary cardiomyopathy

Regulation of secretion of cardiac endocardial endothelial cells by neuropeptide Y. Régulation de la sécrétion des cellules endothéliales endocardiques par le neuropeptide Y.

Modulation of nuclear T-tubules in endocardial endothelium by ET-1. Modulation des tubules-T nucléaires par l'ET-1 au niveau de l'endothelium endocardique

Modulation of cytosolic and nuclear calcium in endocardial endothelium by ET-1

Modulation du ca2+ cytosolique et nucléaire de l`endothélium endocardique par l?T-1

Frequent collaborators

Ghassan Bkaily

Pedro D'Orléans-Juste

Sheldon Magder

Abdelouahed Khalil

Roger LECOMTE

Martin Lepage

Adel Schwertani

Robert Day