Ghassan Bkaily, Université de Sherbrooke

Research

Cardiomyocytes Dépendance Du Sexe Hamsters Normaux Et Cardiomyopathiques Hypertrophie Et Défaillance Cardiaque Imagerie Par Résonance Magnétique (Irm)Ros Sodium Et Calcium Intracellulaire Supplément En Taurine

Latest papers

Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.
Pathophysiology : the official journal of the International Society for Pathophysiology · 2026 · first author
Resting Cytosolic and Nuclear Reactive Oxygen Species (ROS) Are Regulated by the Basal Activity of ET-1 Receptors in Human Vascular Smooth Muscle Cells.
International journal of molecular sciences · 2026 · first author
Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system.
Canadian journal of physiology and pharmacology · 2026 · first author

All 60 publications

Latest funding

Role of the sodium/calcium exchanger in regulation of nuclear Na+ and Ca2+ homeostasis by Angiotensin II in heart cells.
NSERC · 2024 · Principal investigator
$46,000
Rôle d'un supplément de taurine pour la prévention de la nécrose, de l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire.
CIHR · 2022 · Principal investigator
$830,025
Regulation of nuclear calcium and ROS by Angiotensin II in heart cells. Régulation du calcium et ROS nucléaires par l'angiotensine II dans les cellules cardiaques.
NSERC · 2016 · Principal investigator
$168,000

All 9 grants and awards

60 publications.

01

Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.

Bkaily G, Normand A, Jazzar A, Najibeddine H, Jacques D

Pathophysiology : the official journal of the International Society for Pathophysiology2026First author

DOI: 10.3390/pathophysiology33020037 PMID: 42347022

02

Resting Cytosolic and Nuclear Reactive Oxygen Species (ROS) Are Regulated by the Basal Activity of ET-1 Receptors in Human Vascular Smooth Muscle Cells.

Bkaily G, Semaan R, Jacques D

International journal of molecular sciences2026First author

DOI: 10.3390/ijms27062524 PMID: 41898389

03

Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system.

Bkaily G, Jazzar A, Jacques D

Canadian journal of physiology and pharmacology2026First author

DOI: 10.1139/cjpp-2025-0240 PMID: 41086444

04

Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System.

Bkaily G, Jazzar A, Abou-Aichi A, Jacques D

Biomedicines2025First author

DOI: 10.3390/biomedicines13081842 PMID: 40868096

05

In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner.

Jazzar A, Jacques D, Abou-Aichi A, Bkaily G

Pathophysiology : the official journal of the International Society for Pathophysiology2025Senior author

DOI: 10.3390/pathophysiology32010012 PMID: 40137469

06

Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent.

Bkaily G, Simon Y, Abou Abdallah J, Ouertane C, Essalhi A, Khalil A, Jacques D

Nutrients2024First author

DOI: 10.3390/nu16070946 PMID: 38612980

07

Taurine Prevents Angiotensin II-Induced Human Endocardial Endothelium Morphological Remodeling and the Increase in Cytosolic and Nuclear Calcium and ROS.

Jacques D, Bkaily G

Nutrients2024Senior author

DOI: 10.3390/nu16050745 PMID: 38474873

08

High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory.

Simon Y, Jacques D, Bkaily G

Canadian journal of physiology and pharmacology2023Senior author

DOI: 10.1139/cjpp-2023-0087 PMID: 37290125

09

Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System.

Bkaily G, Jacques D

International journal of molecular sciences2023First author

DOI: 10.3390/ijms24108803 PMID: 37240147

10

Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases.

Bkaily G, Jacques D

International journal of molecular sciences2023First author

DOI: 10.3390/ijms24031998 PMID: 36768314

Role of the sodium/calcium exchanger in regulation of nuclear Na+ and Ca2+ homeostasis by Angiotensin II in heart cells.

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Bkaily, Ghassan

Keywords: cardiovascular cells; angiotensin ii; heart; nuclear envelope; nuclear membranes receptors; quantitative 3d confocal microscopy imaging; nuclear sodium and calcium homeostasis; sodium/calcium exchanger; sodium imaging; calcium imaging

$46,000

Rôle d'un supplément de taurine pour la prévention de la nécrose, de l'hypertrophie, de la défaillance cardiaque et de la mort prématurée dans la cardiomyopathie héréditaire.

Principal investigatorCIHR2022Project Grant

Principal investigators: Jacques, Danielle; Bkaily, Ghassan

Keywords: Cardiomyocytes; Dépendance Du Sexe; Hamsters Normaux Et Cardiomyopathiques; Hypertrophie Et Défaillance Cardiaque; Imagerie Par Résonance Magnétique (Irm); Ros; Sodium Et Calcium Intracellulaire; Supplément En Taurine; Tomographie D'Émission Par Positron (Tep); Étude In Vivo

$830,025

Regulation of nuclear calcium and ROS by Angiotensin II in heart cells. Régulation du calcium et ROS nucléaires par l'angiotensine II dans les cellules cardiaques.

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Bkaily, Ghassan

$168,000

Role of ET-1 and Ang II induced cytosolic and nuclear ROS generation in nuclear T-tubules formation in hypertrophy and ageing of human vascular smooth muscle cells.

Nominated PICIHR2012Operating Grant

Principal investigators: Bkaily, Ghassan

Keywords: Calcium Homeostasis; Nuclear Membranes Receptors; Nuclear T-Tubules; Nuclear Transport; Pharmacology Of Nuclear Membranes Receptors; Vascular Aging; Vascular Hypertrophy

$651,185

Roles of sodium-hydrogen exchangers in the development of hereditary cardiomyopathy

Nominated PICIHR2011Operating Grant

Principal investigators: Bkaily, Ghassan

Keywords: Calcium Overload; Cardiomyopathy; Heart Failure; Hypertrophy; Hypotension; Nuclear Membranes Transport; Sodium Overload; Sodium-Hydrogen Exchanger

$663,327

Regulation of nuclear calcium and ros by angiotensin II in heart cells. régulation du calcium et ros nucléaires par l'angiotensione II dans les cellules cardiaques.

Principal investigatorNSERC2011Discovery Grants Program - Individual

Principal investigators: Bkaily, Ghassan

$150,000

Regulation of nuclear calcium by angiotensin II in heart cells

Principal investigatorNSERC2005Discovery Grants Program - Individual

Principal investigators: Bkaily, Ghassan

$164,500

Regulation of nuclear calcium by angiotensin II in heart cells - Regulation du calcium nucléaire par l'Angiotensin II dans les cellules cardiaques

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Bkaily, Ghassan

$24,000

Regulation of nuclear calcium by angiotensin II in heart cells

Principal investigatorNSERC2000Discovery Grants Program - Individual

Principal investigators: Bkaily, Ghassan

$120,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Immunologie-Biologie Cellulaire
Surgery
Médecine
Pharmacologie
Medicine/Cardiology
Rhumatologie
Biochemistry

Co-authors at Université de Sherbrooke, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Danielle Jacques

Immunologie-Biologie Cellulaire

49 shared papers, latest 2026

Pedro D'Orléans-Juste

Pharmacologie

5 shared papers, latest 2010

Sheldon Magder

Surgery

3 shared papers, latest 2018

Abdelouahed Khalil

Médecine

2 shared papers, latest 2024

Hugues Allard-Chamard

Rhumatologie

1 shared papers, latest 2006

Adel Schwertani

Medicine/Cardiology

1 shared papers, latest 2015

Xavier Roucou

Biochemistry

1 shared papers, latest 2021

Jean-Luc Parent

Médecine

1 shared papers, latest 2006

Robert Day

Surgery

1 shared papers, latest 2015

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Cardiomyocytes Dear Professor Bkaily, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Role of the sodium/calcium exchanger in regulation of nuclear Na+ and Ca2+ homeostasis by Angiotensin II in heart cells." (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]