Jeffrey Chen, University of Saskatchewan

Research

Host-Pathogen Interactions Protein Secretion Systems Tuberculosis Virulence Effectors

Latest papers

Applying prior knowledge of regulatory signaling to investigate macrophage cAMP dynamics during Mycobacterium tuberculosis infection.
Scientific reports · 2026
The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis.
npj antimicrobials and resistance · 2025

All 2 publications

Latest funding

Characterizing the novel virulence functions of Mycobacterium tuberculosis type-7 secretion system ESX-1 effectors
CIHR · 2023 · Nominated PI
$100,000
Role of phenotypic heterogeneity in mycobacterial persistence: Prospects for more effective treatment regimens
CIHR · 2022 · Co-investigator
$100,000
Host Directed Therapies in Tuberculosis
CIHR · 2021 · Co-investigator
$750,000

All 4 grants and awards

2 publications.

01

Applying prior knowledge of regulatory signaling to investigate macrophage cAMP dynamics during Mycobacterium tuberculosis infection.

Chen C, Saha P, Reimer J, Wachter S, Chen J, Dhar N, Broderick G

Scientific reports2026

DOI: 10.1038/s41598-026-62042-z PMID: 42432277

02

The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis.

Sahile HA, Christofferson M, Alford MA, Rens C, Haghdadi H, Chao JD, Langdon G, Hancock REW, Chen J, Av-Gay Y

npj antimicrobials and resistance2025

DOI: 10.1038/s44259-025-00143-x PMID: 40760081

Characterizing the novel virulence functions of Mycobacterium tuberculosis type-7 secretion system ESX-1 effectors

Nominated PICIHR2023Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Chen, Jeffrey M

Keywords: Host-Pathogen Interactions; Protein Secretion Systems; Tuberculosis; Virulence Effectors

$100,000

Role of phenotypic heterogeneity in mycobacterial persistence: Prospects for more effective treatment regimens

Co-investigatorCIHR2022Project Grant - PA: Antimicrobial Resistance (Bridge Grant)

Principal investigators: Dhar, Neeraj

Keywords: Antibiotics; Fluorescent Reporter; Heterogeneity; Mouse; Mycobacteria; Organoid; Persistence; Phenotypic Heterogeneity; Single-Cell Imaging; Tuberculosis

$100,000

Host Directed Therapies in Tuberculosis

Co-investigatorCIHR2021Project Grant - PA: Pandemic and Health Emergencies Research

Principal investigators: Av-Gay, Yossef

Keywords: Drug Discovery; Drug Repurposing; Macrophages; Signalling; Tuberculosis

$750,000

Acid pH suppression of mycobacterial type-7 ESX-1 protein secretion

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Chen, Jeffrey

$217,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Vaccine and Infectious Disease Organization
Medicine

Co-authors at University of Saskatchewan, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Neeraj Dhar

Vaccine and Infectious Disease Organization

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Host-Pathogen Interactions Dear Professor Chen, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Applying prior knowledge of regulatory signaling to investigate macrophage cAMP dynamics during Mycobacterium tuberculosis infection." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Characterizing the novel virulence functions of Mycobacterium tuberculosis type-7 secretion system ESX-1 effectors" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jeffrey Chen