Faculty profile

Yossef Av-Gay

ResearcherMedicineUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Yossef Av-Gay

Researcher

Medicine

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
17 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (8 CIHR), most recently in 2026.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Tuberculosis Drug Discovery Host-Pathogen Interactions Antibiotics Hit To Lead Medicinal Chemistry Sar Drug Repurposing

Latest papers

5-Carboxamide-Substituted Barbituric Acids: Promising Scaffolds for Drug Development against Mycobacterium tuberculosis.
ACS infectious diseases · 2026 · senior author
Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages.
ACS infectious diseases · 2026 · senior author
The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis.
npj antimicrobials and resistance · 2025 · senior author

All 76 publications

Latest funding

Developing fenoxacrim derivatives against drug resistant Mycobacterium tuberculosis
CIHR · 2026 · Nominated PI
$963,900
Characterizing the novel virulence functions of Mycobacterium tuberculosis type-7 secretion system ESX-1 effectors
CIHR · 2023 · Co-investigator
$100,000
Repurposing Histamine Receptor 1 (HR1) blockers for host directed therapy of tuberculosis
CIHR · 2023 · Supervisor
$270,000

All 14 grants and awards

76 publications.

5-Carboxamide-Substituted Barbituric Acids: Promising Scaffolds for Drug Development against Mycobacterium tuberculosis.

Sahile HA, Awasthi B, Olsen JE, Afshar H, Kim SW, Amrom I, Nikjo Z, Rankine-Wilson L, Law WWH, Vimalanathan S, Tsui CKM, Rubinstein JL, Page BDG, Av-Gay Y

ACS infectious diseases2026Senior author

DOI: 10.1021/acsinfecdis.6c00420 PMID: 42725973

Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages.

Rankine-Wilson L, Av-Gay Y

ACS infectious diseases2026Senior author

DOI: 10.1021/acsinfecdis.6c00093 PMID: 42384363

The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis.

Sahile HA, Christofferson M, Alford MA, Rens C, Haghdadi H, Chao JD, Langdon G, Hancock REW, Chen J, Av-Gay Y

npj antimicrobials and resistance2025Senior author

DOI: 10.1038/s44259-025-00143-x PMID: 40760081

Vacuolar-ATPase inhibitors are antimicrobial agents active against intracellular mycobacteria.

Rankine-Wilson L, Shapira T, Felker J, Christofferson M, Sahile H, Chao J, Afshar H, Andersen RJ, Sun J, Av-Gay Y

Antimicrobial agents and chemotherapy2025Senior author

DOI: 10.1128/aac.00478-25 PMID: 41170946

Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis infection.

Peña-Díaz S, Chao JD, Rens C, Haghdadi H, Zheng X, Flanagan K, Ko M, Shapira T, Richter A, Maestre-Batlle D, Canseco JO, Gutierrez MG, Duc KD, Pelech S, Av-Gay Y

iScience2024Senior author

DOI: 10.1016/j.isci.2024.110555 PMID: 39175770

The diversity of clinical Mycobacterium abscessus isolates in morphology, glycopeptidolipids and infection rates in a macrophage model.

Pichler V, Dalkilic L, Shoaib G, Shapira T, Rankine-Wilson L, Boudehen YM, Chao JD, Sexton D, Prieto M, Quon BS, Tocheva EI, Kremer L, Hsiao W, Av-Gay Y

Journal of medical microbiology2024Senior author

DOI: 10.1099/jmm.0.001869 PMID: 39158416

The antimicrobial activity of innate host-directed therapies: A systematic review.

Shapira T, Christofferson M, Av-Gay Y

International journal of antimicrobial agents2024Senior author

DOI: 10.1016/j.ijantimicag.2024.107138 PMID: 38490573

CAT PETR: a graphical user interface for differential analysis of phosphorylation and expression data.

Flanagan K, Pelech S, Av-Gay Y, Dao Duc K

Statistical applications in genetics and molecular biology2023

DOI: 10.1515/sagmb-2023-0017 PMID: 37592851

Acidic pH modulates Burkholderia cenocepacia antimicrobial susceptibility in the cystic fibrosis nutritional environment.

Morales LD, Av-Gay Y, Murphy MEP

Microbiology spectrum2023

DOI: 10.1128/spectrum.02731-23 PMID: 37966209

Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication.

Shapira T, Vimalanathan S, Rens C, Pichler V, Peña-Díaz S, Jordana G, Rees W, Winkler DFH, Sarai I, Steiner T, Jean F, Pelech S, Av-Gay Y

Molecular biomedicine2022Senior author

DOI: 10.1186/s43556-022-00111-1 PMID: 36508083

Developing fenoxacrim derivatives against drug resistant Mycobacterium tuberculosis

Nominated PICIHR2026Project Grant

Principal investigators: Av-Gay, Yossef

Keywords: Antibiotics; Drug Discovery; Hit To Lead; Medicinal Chemistry; Sar; Tuberculosis

$963,900

Characterizing the novel virulence functions of Mycobacterium tuberculosis type-7 secretion system ESX-1 effectors

Co-investigatorCIHR2023Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Chen, Jeffrey M

Keywords: Host-Pathogen Interactions; Protein Secretion Systems; Tuberculosis; Virulence Effectors

$100,000

Repurposing Histamine Receptor 1 (HR1) blockers for host directed therapy of tuberculosis

SupervisorCIHR2023CIHR REDI Early Career Transition Award - Pandemic Prepared./Health Emergencies

Principal investigators: Sahile, Henok A

Keywords: Antihistamine Drugs; Drug Discovery; Drug Repurposing; Host Directed Therapy; Medicinal Chemistry; Tuberculosis

$270,000

Host Directed Therapies in Tuberculosis

Nominated PICIHR2021Project Grant - PA: Pandemic and Health Emergencies Research

Principal investigators: Av-Gay, Yossef

Keywords: Drug Discovery; Drug Repurposing; Macrophages; Signalling; Tuberculosis

$750,000

Protein phase separation: A new mechanism of protein function regulation in Mycobacterium tuberculosis

Co-investigatorCIHR2020Project Grant

Principal investigators: Gsponer, Jörg; Mcintosh, Lawrence P

Keywords: Computational Biology; Fluorescence Microscopy; Microbial Signal Transduction; Molecular Mechanism Of Virulence; Nmr Spectroscopy; Protein Phase Separation; Proteomic And Protein Interaction Networks; Regulation Of Abc Transporter Activity

$887,400

Host-pathogen interaction directed therapies in Tuberculosis

Nominated PICIHR2016Project Grant

Principal investigators: Av-Gay, Yossef

Keywords: Drug Development; Host-Pathogen Interactions; Natural Products; Tuberculosis

$1,009,800

Intracellular growth of Mycobacterium tuberculosis: Prospects for drug discovery.

Nominated PICIHR2016Project Grant

Principal investigators: Av-Gay, Yossef

Keywords: Drug Targets; Host-Pathogen Interactions; Microbial Genetics; Tuberculosis

$802,725

The Genetic and Metabolic Basis of Intrinsic Resistance and Phenotypic Drug Tolerance in Mycobacterium tuberculosis.

Principal investigatorCIHR2010Canada-UK Partnership on Antibiotic Resistance - LOI

Principal investigators: Thompson, Charles J; Av-Gay, Yossef; Stokes, Richard W

Keywords: Bacteria; Dormancy; Genetics; Intrinsic Antibiotic Resistance; Macrophages; Metabolism; Mycobacterium Tuberculosis; Persistor; Phenotypic Tolerance; Tuberculosis

Molecular analysis of Mycobacterium tuberculosis Signalling

Nominated PICIHR2010Operating Grant

Principal investigators: Av-Gay, Yossef

Keywords: Molecular Biology; Phosphoproteins; Protein Kinases; Signal Transduction; Tuberculosis

$745,180

PtpA, a Mycobacterium Tuberculosis Protein, is Involved in Blocking Macrophage's Signaling Pathway.

SupervisorCIHR2009Master's Award: Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Poirier, Valerie

Keywords: Macrophages; Mycobaterium Tuberculosis; Phosphatase; Protein-Protein Interaction; Signal Transduction; Site-Directed Mutagenesis; Vacuolar Protein Sorting

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Yossef Av-Gay

Research

Latest papers

Latest funding

5-Carboxamide-Substituted Barbituric Acids: Promising Scaffolds for Drug Development against Mycobacterium tuberculosis.

Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages.

The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis.

Vacuolar-ATPase inhibitors are antimicrobial agents active against intracellular mycobacteria.

Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis infection.

The diversity of clinical Mycobacterium abscessus isolates in morphology, glycopeptidolipids and infection rates in a macrophage model.

The antimicrobial activity of innate host-directed therapies: A systematic review.

CAT PETR: a graphical user interface for differential analysis of phosphorylation and expression data.

Acidic pH modulates Burkholderia cenocepacia antimicrobial susceptibility in the cystic fibrosis nutritional environment.

Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication.

Developing fenoxacrim derivatives against drug resistant Mycobacterium tuberculosis

Characterizing the novel virulence functions of Mycobacterium tuberculosis type-7 secretion system ESX-1 effectors

Repurposing Histamine Receptor 1 (HR1) blockers for host directed therapy of tuberculosis

Host Directed Therapies in Tuberculosis

Protein phase separation: A new mechanism of protein function regulation in Mycobacterium tuberculosis

Host-pathogen interaction directed therapies in Tuberculosis

Intracellular growth of Mycobacterium tuberculosis: Prospects for drug discovery.

The Genetic and Metabolic Basis of Intrinsic Resistance and Phenotypic Drug Tolerance in Mycobacterium tuberculosis.

Molecular analysis of Mycobacterium tuberculosis Signalling

PtpA, a Mycobacterium Tuberculosis Protein, is Involved in Blocking Macrophage's Signaling Pathway.

Frequent collaborators

Horacio Bach

Michel Roberge

Neora Pick

Theodore Steiner

William Hsiao

Henok Sahile

Jeffrey Chen

Nathan Magarvey

Thibault Mayor

Aziz Ghahary

Neil Reiner

Anne-Claude Gingras

Charles Boone

Yossef Av-Gay

Research

Latest papers

Latest funding

5-Carboxamide-Substituted Barbituric Acids: Promising Scaffolds for Drug Development against Mycobacterium tuberculosis.

Comparative Phenotypic Screening Identifies Protein Synthesis Inhibitors as Compounds That Enhance Early Acidification of Mycobacterium tuberculosis in Macrophages.

The Parkinson's drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis.

Vacuolar-ATPase inhibitors are antimicrobial agents active against intracellular mycobacteria.

Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis infection.

The diversity of clinical Mycobacterium abscessus isolates in morphology, glycopeptidolipids and infection rates in a macrophage model.

The antimicrobial activity of innate host-directed therapies: A systematic review.

CAT PETR: a graphical user interface for differential analysis of phosphorylation and expression data.

Acidic pH modulates Burkholderia cenocepacia antimicrobial susceptibility in the cystic fibrosis nutritional environment.

Inhibition of glycogen synthase kinase-3-beta (GSK3&#x3b2;) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication.

Frequent collaborators

Horacio Bach

Michel Roberge

Neora Pick

Theodore Steiner

William Hsiao

Henok Sahile

Jeffrey Chen

Nathan Magarvey

Thibault Mayor

Aziz Ghahary

Neil Reiner

Anne-Claude Gingras

Charles Boone

Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication.