Emmanuelle Cordat

Research

Acidosis Epithelial Cells Hypertension Kidney Disease Membrane Proteins Nephrocalcinosis Polarization Transgenic Mice

Latest papers

A-intercalated cell dysfunction disrupts renal epithelial-immune balance and impairs host defense during UTI.
American journal of physiology. Renal physiology · 2026 · senior author
SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy.
eLife · 2026 · senior author
Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology.
Function (Oxford, England) · 2026

All 38 publications

Latest funding

Protease Targeted Therapeutics to Address the Global AMR Threat Associated with Pathogenic E. coli
CIHR · 2026 · Co-investigator
$1,204,876
Membrane Proteins in Health and Disease-Canadian Society of Molecular Biosciences 69th Annual Meeting
CIHR · 2025 · Co-investigator
$10,000
Physiological characterization of renal collecting duct cells
NSERC · 2024 · Principal investigator
$55,000

All 10 grants and awards

38 publications.

01

A-intercalated cell dysfunction disrupts renal epithelial-immune balance and impairs host defense during UTI.

Chelangarimiyandoab F, MacNaughton K, Essuman G, Cordat E

American journal of physiology. Renal physiology2026Senior author

DOI: 10.1152/ajprenal.00061.2026 PMID: 42294520

02

SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy.

Essuman G, Rizvi M, Almomani E, Ullah SAKM, Hasib SMA, Chelangarimiyandoab F, Mungara P, Schmitt MJ, Hureaux M, Vargas-Poussou R, Touret N, Cordat E

eLife2026Senior author

DOI: 10.7554/elife.108253 PMID: 41778592

03

Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology.

Chelangarimiyandoab F, Lavoie JC, Flamand N, Cordat E, Breton S

Function (Oxford, England)2026

DOI: 10.1152/function.087.2025 PMID: 41401426

04

Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations.

Mungara P, MacNaughton K, Ullah AKMS, Essuman G, Chelangarimiyandoab F, Mumtaz R, Hennings JC, Hübner CA, Eladari D, Alexander RT, Cordat E

Disease models & mechanisms2025Senior author

DOI: 10.1242/dmm.052138 PMID: 40289527

05

Unraveling the molecular landscape of kAE1: a narrative review.

Mungara P, Waiss M, Hartwig S, Burger D, Cordat E

Canadian journal of physiology and pharmacology2024Senior author

DOI: 10.1139/cjpp-2023-0482 PMID: 38669699

06

Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in claudin-4 phosphorylation.

Lashhab R, Essuman G, Chavez-Canales M, Alexander RT, Cordat E

Heliyon2023Senior author

DOI: 10.1016/j.heliyon.2023.e22280 PMID: 38034706

07

Urinary Tract Infections: Renal Intercalated Cells Protect against Pathogens.

Chelangarimiyandoab F, Mungara P, Batta M, Cordat E

Journal of the American Society of Nephrology : JASN2023Senior author

DOI: 10.1681/asn.0000000000000187 PMID: 37401780

08

Biochemical characterization of two novel mutations in the human high-affinity choline transporter 1 identified in a patient with congenital myasthenic syndrome.

Rizvi M, Truong TK, Zhou J, Batta M, Moran ES, Pappas J, Chu ML, Caluseriu O, Evrony GD, Leslie EM, Cordat E

Human molecular genetics2023Senior author

DOI: 10.1093/hmg/ddac309 PMID: 36611016

09

Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.

Beggs MR, Young K, Pan W, O'Neill DD, Saurette M, Plain A, Rievaj J, Doschak MR, Cordat E, Dimke H, Alexander RT

Proceedings of the National Academy of Sciences of the United States of America2021

DOI: 10.1073/pnas.2111247118 PMID: 34810264

10

Boosting endoplasmic reticulum folding capacity reduces unfolded protein response activation and intracellular accumulation of human kidney anion exchanger 1 in Saccharomyces cerevisiae.

Li X, Cordat E, Schmitt MJ, Becker B

Yeast (Chichester, England)2021

DOI: 10.1002/yea.3652 PMID: 34033682

Protease Targeted Therapeutics to Address the Global AMR Threat Associated with Pathogenic E. coli

Co-investigatorCIHR2026Project Grant

Principal investigators: Lemieux, Joanne M

Keywords: Bacterial Infections; Biofilm; Drug Development; Enzymology; Ibd; Pili; Protease; Proteolytic Inhibitor; Structural Biology; Uti

$1,204,876

Membrane Proteins in Health and Disease-Canadian Society of Molecular Biosciences 69th Annual Meeting

Co-investigatorCIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Leslie, Elaine M

Keywords: Membrane Protein Biogenesis; Membrane Proteins; Membrane Proteins And Disease; Membrane Signaling; Physiology Of Ion Channels; Physiology Of Transporters; Structure Of Membrane Proteins

$10,000

Physiological characterization of renal collecting duct cells

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Cordat, Emmanuelle

Keywords: kidney; collecting duct; principal cells; intercalated cells; epithelium; differentiation; cell culture; model

$55,000

Physiological and pathophysiological roles of renal intercalated cells

Nominated PICIHR2019Project Grant

Principal investigators: Cordat, Emmanuelle

Keywords: Acidosis; Epithelial Cells; Hypertension; Kidney Disease; Kidney Stones; Membrane Proteins; Nephrocalcinosis; Polarization; Tight Junctions; Transgenic Mice

$826,200

Emerging roles of renal intercalated cells

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Cordat, Emmanuelle

$156,000

Physiological mechanisms of distal renal tubular acidosis

Nominated PICIHR2015Operating Grant

Principal investigators: Cordat, Emmanuelle

Keywords: Acidosis; Epithelial Cells; Hypertension; Kidney Disease; Membrane Proteins; Nephrocalcinosis; Polarization; Protein Biosynthesis; Trafficking; Transgenic Mice

$685,311

NSERC CREATE - International Research Training Group in Membrane Biology

Co-investigatorNSERC2012Collaborative Research and Training Experience

Principal investigators: Casey, Joseph

$1,492,665

Cellular mechanisms of distal renal tubular acidosis

Nominated PICIHR2010Operating Grant

Principal investigators: Cordat, Emmanuelle

Keywords: Confocal Microscopy; Epithelial Cells; Kidney Disease; Membrane Proteins; Mutagenesis; Protein Biosynthesis

$316,182

Cellular mechanisms of distal renal tubular acidosis

Nominated PICIHR2009Operating Grant - PA: Institute of Genetics (Bridge Funding)

Principal investigators: Cordat, Emmanuelle

Keywords: Confocal Microscopy; Epithelial Cells; Kidney Disease; Membrane Proteins; Mutagenesis; Protein Biosynthesis

$100,000

Characterizing a new AE1 mutant causing HS and dRTA

Nominated PICIHR2008Operating Grant: SickKids-CIHR-IHDCYH New Investigator Grants

Principal investigators: Cordat, Emmanuelle

Keywords: Cell Biology; Membrane Protein; Nephrology

$64,365

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology
Biochemistry
Cellular and Molecular Medicine
Pediatrics
Médecine
Biomedical Sciences
Obstetrics, Gynecology, and Reproductive Sciences

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Nicolas Touret

Biochemistry

4 shared papers, latest 2026

Sylvie Breton

Obstetrics, Gynecology, and Reproductive Sciences

1 shared papers, latest 2026

Sunny Hartwig

Biomedical Sciences

1 shared papers, latest 2024

Dylan Burger

Cellular and Molecular Medicine

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Acidosis Dear Professor Cordat, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A-intercalated cell dysfunction disrupts renal epithelial-immune balance and impairs host defense during UTI." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Physiological characterization of renal collecting duct cells" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Emmanuelle Cordat

Research

Latest papers

Latest funding

A-intercalated cell dysfunction disrupts renal epithelial-immune balance and impairs host defense during UTI.

SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy.

Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology.

Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations.

Unraveling the molecular landscape of kAE1: a narrative review.

Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in claudin-4 phosphorylation.

Urinary Tract Infections: Renal Intercalated Cells Protect against Pathogens.

Biochemical characterization of two novel mutations in the human high-affinity choline transporter 1 identified in a patient with congenital myasthenic syndrome.

Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.

Boosting endoplasmic reticulum folding capacity reduces unfolded protein response activation and intracellular accumulation of human kidney anion exchanger 1 in Saccharomyces cerevisiae.

Protease Targeted Therapeutics to Address the Global AMR Threat Associated with Pathogenic E. coli

Membrane Proteins in Health and Disease-Canadian Society of Molecular Biosciences 69th Annual Meeting

Physiological characterization of renal collecting duct cells

Physiological and pathophysiological roles of renal intercalated cells

Emerging roles of renal intercalated cells

Physiological mechanisms of distal renal tubular acidosis

NSERC CREATE - International Research Training Group in Membrane Biology

Cellular mechanisms of distal renal tubular acidosis

Cellular mechanisms of distal renal tubular acidosis

Characterizing a new AE1 mutant causing HS and dRTA

Frequent collaborators

Nicolas Touret

Mathieu Lemaire

Sylvie Breton

Nicolas Flamand

Sunny Hartwig

Dylan Burger