Sylvie Breton, Université Laval

Research

Epithelial Cells Epididymis Extracellular Vesicles Intercellular Communication Networks Luminal Acidification Model System Purinergic Regulation Sperm Maturation

Latest papers

Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients.
American journal of physiology. Heart and circulatory physiology · 2026 · senior author
Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology.
Function (Oxford, England) · 2026 · senior author
Regulation of NHE3 subcellular localization in epididymal principal cells: pH, cyclic adenosine 3,5 monophosphate (cAMP), and adenosine signaling.
Andrology · 2025 · senior author

All 13 publications

Latest funding

Rôle du récepteur pro-inflammatoire P2Y14 dans l'insuffisance rénale aiguë causée par une ischémie
CIHR · 2024 · Supervisor
$120,000
Facteurs associés à un échec à l'amélioration de la qualité de vie suivant une prise en charge pour endométriose : une étude translationnelle avec analyse qualitative et quantitative
CIHR · 2024 · Co-investigator
$1,212,525
Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract
CIHR · 2022 · Nominated PI
$883,576

All 6 grants and awards

13 publications.

01

Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients.

Légaré C, Caron P, Al-Bataineh MM, Ford A, Emlet DR, Deslauriers J, Brown D, Guillemette C, Mohammadi S, Breton S

American journal of physiology. Heart and circulatory physiology2026Senior author

DOI: 10.1152/ajpheart.00233.2026 PMID: 42613023

02

Molecular mechanisms of acute inflammation: systemic responses and kidney-specific pathophysiology.

Chelangarimiyandoab F, Lavoie JC, Flamand N, Cordat E, Breton S

Function (Oxford, England)2026Senior author

DOI: 10.1152/function.087.2025 PMID: 41401426

03

Regulation of NHE3 subcellular localization in epididymal principal cells: pH, cyclic adenosine 3,5 monophosphate (cAMP), and adenosine signaling.

Belardin LB, Brochu K, Légaré C, Breton S

Andrology2025Senior author

DOI: 10.1111/andr.13820 PMID: 39663831

04

Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis.

Brochu K, Minas A, Berloffa Belardin L, Légaré C, Breton S

Function (Oxford, England)2025Senior author

DOI: 10.1093/function/zqaf016 PMID: 40128095

05

Chimeras Derived from a P2Y14 Receptor Antagonist and UDP-Sugar Agonists for Potential Treatment of Inflammation.

Wen Z, Pramanik A, Lewicki SA, Jung YH, Gao ZG, Randle JCR, Breton S, Chen Z, Whitehead GS, Salvemini D, Cook DN, Jacobson KA

ACS pharmacology & translational science2024

DOI: 10.1021/acsptsci.4c00489 PMID: 39421658

06

Immunoregulatory mechanisms between epithelial clear cells and mononuclear phagocytes in the epididymis.

Battistone MA, Elizagaray ML, Barrachina F, Ottino K, Mendelsohn AC, Breton S

Andrology2024Senior author

DOI: 10.1111/andr.13509 PMID: 37572347

07

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation.

Toriseva M, Björkgren I, Junnila A, Mehmood A, Mattsson J, Raimoranta I, Kim B, Laiho A, Nees M, Elo L, Poutanen M, Breton S, Sipilä P

Cellular and molecular life sciences : CMLS2024

DOI: 10.1007/s00018-024-05211-5 PMID: 38630262

08

Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists.

Wen Z, Pramanik A, Lewicki SA, Jung YH, Gao ZG, Randle JCR, Cronin C, Chen Z, Giancotti LA, Whitehead GS, Liang BT, Breton S, Salvemini D, Cook DN, Jacobson KA

Journal of medicinal chemistry2023

DOI: 10.1021/acs.jmedchem.3c00664 PMID: 37382926

09

Commentary: Novel preoperative predictors of acute kidney injury following cardiac surgery: Is it a game changer?

Breton S, Kalavrouziotis D, Mohammadi S

The Journal of thoracic and cardiovascular surgery2023First author

DOI: 10.1016/j.jtcvs.2021.04.055 PMID: 33992462

10

Purinergic signaling in the male reproductive tract.

Belardin LB, Brochu K, Légaré C, Battistone MA, Breton S

Frontiers in endocrinology2022Senior author

DOI: 10.3389/fendo.2022.1049511 PMID: 36419764

Rôle du récepteur pro-inflammatoire P2Y14 dans l'insuffisance rénale aiguë causée par une ischémie

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Lavoie, Jean-Philippe C

Keywords: Biomarqueur; Cellules Intercalaires; Cytométrie En Flux; Développement De Stratégies Thérapeutiques; Inflammation Stérile; Insuffisance Rénale; Ischémie-Reperfusion; Macrophages; Microscopie Confocale; Neutrophiles

$120,000

Facteurs associés à un échec à l'amélioration de la qualité de vie suivant une prise en charge pour endométriose : une étude translationnelle avec analyse qualitative et quantitative

Co-investigatorCIHR2024Project Grant

Principal investigators: Maheux-Lacroix, Sarah

Keywords: Diversité Sexuelle Et De Genre; Douleur Pelvienne Chronique; Endométriose; Qualité De Vie

$1,212,525

Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract

Nominated PICIHR2022Project Grant

Principal investigators: Breton, Sylvie

Keywords: Epididymis; Epithelial Cells; Extracellular Vesicles; Intercellular Communication Networks; Luminal Acidification; Model System; Purinergic Regulation; Sperm Maturation; Spermatozoa Fertility Parameters

$883,576

Understanding the variations in clinical presentations of endometriosis: a pan-Canadian cohort study

Co-investigatorCIHR2022Project Grant - PA: Women's Health Research - Early Career Researcher Grant

Principal investigators: Maheux-Lacroix, Sarah; Yong, Paul

Keywords: Endometriosis; Gynecology; Pan-Canadian; Quality Of Life

$100,000

Elucidating the role of the pro-inflammatory P2Y14 receptor in acute kidney injury

Nominated PICIHR2021Project Grant

Principal investigators: Breton, Sylvie

Keywords: Acute Kidney Injury; Acute Tubular Necrosis; Aki To Ckd Transition; Chronic Kidney Disease; Epithelial Cells; Immune Cells; Ischemia; Renal Inflammation; Sepsis

$918,000

Canada Research Chair - Tier 1

Nominated PICIHR2019Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Breton, Sylvie

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Obstetrics, Gynecology, and Reproductive Sciences
Pharmacy
Obstétrique et gynécologie
Physiology
Médecine
Medicine
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Chantal Guillemette

Pharmacy

2 shared papers, latest 2026

Jessica Deslauriers

Faculty

1 shared papers, latest 2026

Robert Sullivan

Obstetrics, Gynecology, and Reproductive Sciences

1 shared papers, latest 2022

Paul Fortin

Medicine

1 shared papers, latest 2022

Nicolas Flamand

Médecine

1 shared papers, latest 2026

Emmanuel Bujold

Obstétrique et gynécologie

1 shared papers, latest 2022

Emmanuelle Cordat

Physiology

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Epithelial Cells Dear Professor Breton, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]