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Research
Latest papers
Correction: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning.
Basic research in cardiology · 2025
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning.
Basic research in cardiology · 2025
Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Nature cell biology · 2023
Latest funding
- $1,071,000
Cardiac energy metabolism in HFrEF and HFpEF
CIHR · 2024 · Nominated PI
- $1,009,800
Cardiac insulin signalling in diabetic cardiomyopathy
CIHR · 2023 · Nominated PI
- $105,000
Increasing Myocardial Ketone Oxidation as an Approach to Treat Heart Failure
CIHR · 2019 · Supervisor
12 publications.
Correction: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning.
Hernandez-Resendiz S, Vilskersts R, Aluja D, Andreadou I, Bencsik P, Dambrova M, Efentakis P, Gao F, Giricz Z, Brenner GB, Sayour NV, Gergely TG, Makkos A, Inserte J, Kelly-Laubscher R, Kiss A, Krieg T, Kwak BR, Lecour S, Lopaschuk G, Mączewski M, Waszkiewicz M, Oknińska M, Pagliaro P, Podesser B, Prag HA, Ruiz-Meana M, Szabados T, Zuurbier CJ, Ferdinandy P, Hausenloy DJ
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning.
Hernandez-Resendiz S, Vilskersts R, Aluja D, Andreadou I, Bencsik P, Dambrova M, Efentakis P, Gao F, Giricz Z, Brenner GB, Sayour NV, Gergely TG, Makkos A, Inserte J, Kelly-Laubscher R, Kiss A, Krieg T, Kwak BR, Lecour S, Lopaschuk G, Mączewski M, Waszkiewicz M, Oknińska M, Pagliaro P, Podesser B, Prag HA, Ruiz-Meana M, Szabados T, Zuurbier CJ, Ferdinandy P, Hausenloy DJ
Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A, Nejad FK, Mahmoodzadeh A, Sato T, Ramos-Alonso L, Romero AM, Martinez-Pastor MT, Jiang SC, Sah-Teli SK, Li L, Bentrem D, Lopaschuk G, Ben-Sahra I, O'Halloran TV, Shilatifard A, Puig S, Bergelson J, Koivunen P, Ardehali H
Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation.
Hall AR, Karwi QG, Kumar S, Dongworth R, Aksentijević D, Altamimi TR, Fridianto KT, Chinda K, Hernandez-Resendiz S, Mahmood MU, Michelakis E, Ramachandra CJ, Ching J, Vicencio JM, Shattock MJ, Kovalik JP, Yellon DM, Lopaschuk G, Hausenloy DJ
Corrigendum to "Trimetazidine in cardiovascular medicine," [Int. J. Cardiol., 293 (2019) 39-44].
Marzilli M, Vinereanu D, Lopaschuk G, Chen Y, Dalal JJ, Danchin N, Etriby E, Ferrari R, Gowdak LH, Lopatin Y, Milicic D, Parkhomenko A, Pinto F, Ponikowski P, Seferovic P, Rosano GMC
Trimetazidine in cardiovascular medicine.
Marzilli M, Vinereanu D, Lopaschuk G, Chen Y, Dalal JJ, Danchin N, Etriby E, Ferrari R, Gowdak LH, Lopatin Y, Milicic D, Parkhomenko A, Pinto F, Ponikowski P, Seferovic P, Rosano GMC
Statins Reduce Epicardial Adipose Tissue Attenuation Independent of Lipid Lowering: A Potential Pleiotropic Effect.
Raggi P, Gadiyaram V, Zhang C, Chen Z, Lopaschuk G, Stillman AE
Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy.
Mohamed IA, Gadeau AP, Fliegel L, Lopaschuk G, Mlih M, Abdulrahman N, Fillmore N, Mraiche F
Cardiovascular remodelling in coronary artery disease and heart failure.
Heusch G, Libby P, Gersh B, Yellon D, Böhm M, Lopaschuk G, Opie L
Postresuscitation cyclosporine treatment attenuates myocardial and cardiac mitochondrial injury in newborn piglets with asphyxia-reoxygenation.
Gill RS, Lee TF, Manouchehri N, Liu JQ, Lopaschuk G, Bigam DL, Cheung PY
Cardiac energy metabolism in HFrEF and HFpEF
Principal investigators: Lopaschuk, Gary D
Keywords: Energy Metabolism; Fatty Acid Oxidation; Glucose Oxidation; Heart Failure; Hfpef; Hfref; Ketone Oxidation; Mitochondria; Pyruvate Dehydrogenase Kinase; Sglt2 Inhibitors
Cardiac insulin signalling in diabetic cardiomyopathy
Principal investigators: Lopaschuk, Gary D
Keywords: Branched Chain Amino Acids; Diabetes; Diabetic Cardiomyopathy; Fatty Acid Oxidation; Glucose Oxidation; Heart Failure; Insulin Signalling; Ketone Oxidation; Mitochondria
Increasing Myocardial Ketone Oxidation as an Approach to Treat Heart Failure
Principal investigators: Ho, Kim L
Keywords: Cardiac Metabolism; Heart Failure; Ketogenic Diet; Ketone Body
Branched Chain Amino Acid Contribution to Cardiac Insulin Resistance in Heart Failure
Principal investigators: Lopaschuk, Gary D
Keywords: Branched Chain Amino Acids; Fatty Acid Oxidation; Glucose Oxidation; Heart Failure; Insulin Resistance; Mtor; Obesity
The metabolic basis if heart failure in diabetes and obesity
Principal investigators: Lopaschuk, Gary D
Keywords: Acetylation; Diabetes; Fatty Acid Oxidation; Glucose Oxidation; Heart Failure; Hypertrophy; Insulin Resistance; Mitochondria; Mtor; Obesity
Optimizing cardiac energy metabolism to treat heart disease
Principal investigators: Lopaschuk, Gary D
Keywords: Energy Metabolism; Fatty Acid Oxidation; Glucose Oxidation; Heart; Heart Failure; Ischemic Heart Disease; Ketone Oxidation; Mitochondria
Energy substrate metabolism in the ischemic and non-ischemic heart
Principal investigators: Lopaschuk, Gary D
Keywords: Biochemical Analysis; Energy Metabolism; Fatty Acid Oxidation; Heart; Ischemic Heart Disease; Isolated Heart Tissue; Myocardium
Energy metabolism in the newborn heart.
Principal investigators: Lopaschuk, Gary D
Keywords: Biochemical Analysis; Congenital Heart Disease; Heart; Ischemic Heart Disease; Isolated Heart Tissue; Myocardium; Newborn
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Zamaneh Kassiri and Carlos Fernandez-Patron: 11 shared papers
- Gary Lopaschuk and Po-Yin Cheung: 1 shared paper
- Gary Lopaschuk and Larry Fliegel: 1 shared paper
- Gary Lopaschuk and Zamaneh Kassiri: 1 shared paper
- Gary Lopaschuk and Carlos Fernandez-Patron: 1 shared paper
- Pediatrics
- Biochemistry
- Physiology
Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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