Larry Fliegel, University of Alberta

Research

Cardiovascular Hypertrophy Ischemia Membrane Proteins Protein Interactions Signaling

Latest papers

Anoikis: To Die or Not to Die?
International journal of molecular sciences · 2026 · senior author
Characterization of Critical Amino Acids in the Transport and Selectivity of the Plant Na+/H+ Exchanger Plasma Membrane SOS1.
International journal of molecular sciences · 2025 · senior author
Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts.
Pharmaceuticals (Basel, Switzerland) · 2024 · senior author

All 99 publications

Latest funding

Mechanism of Plasma Membrane Mediated Na+/H+ Exchange and Salt Tolerance in Plants, Animals and Yeast
NSERC · 2020 · Principal investigator
$198,000
Upgrade Advanced EPR/DEER Spectroscopy Facility
NSERC · 2020 · Co-investigator
$150,000
System for Resolving Native Membrane Nanodiscs and Protein Assemblies
NSERC · 2018 · Co-investigator
$150,000

All 14 grants and awards

99 publications.

01

Anoikis: To Die or Not to Die?

Koltai T, Fliegel L

International journal of molecular sciences2026Senior author

DOI: 10.3390/ijms27020579 PMID: 41596231

02

Characterization of Critical Amino Acids in the Transport and Selectivity of the Plant Na+/H+ Exchanger Plasma Membrane SOS1.

Ullah A, Dutta D, Fliegel L

International journal of molecular sciences2025Senior author

DOI: 10.3390/ijms26083518 PMID: 40332001

03

Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts.

Koltai T, Fliegel L

Pharmaceuticals (Basel, Switzerland)2024Senior author

DOI: 10.3390/ph17060744 PMID: 38931411

04

Exploring monocarboxylate transporter inhibition for cancer treatment.

Koltai T, Fliegel L

Exploration of targeted anti-tumor therapy2024Senior author

DOI: 10.37349/etat.2024.00210 PMID: 38464385

05

The Relationship between Trop-2, Chemotherapeutic Drugs, and Chemoresistance.

Koltai T, Fliegel L

International journal of molecular sciences2023Senior author

DOI: 10.3390/ijms25010087 PMID: 38203255

06

Structure and Function of Membrane Proteins.

Fliegel L

International journal of molecular sciences2023First author

DOI: 10.3390/ijms24098350 PMID: 37176058

07

Acute SGLT-2i treatment improves cardiac efficiency during myocardial ischemia independent of Na+/H+ exchanger-1.

Baker HE, Tune JD, Mather KJ, Blaettner BS, Clark HE, Li F, Li X, Kowala MC, Fliegel L, Goodwill AG

International journal of cardiology2022

DOI: 10.1016/j.ijcard.2022.06.054 PMID: 35753619

08

The Remaining Conundrum of the Role of the Na+/H+ Exchanger Isoform 1 (NHE1) in Cardiac Physiology and Pathology: Can It Be Rectified?

Karmazyn M, Pierce GN, Fliegel L

Reviews in cardiovascular medicine2022Senior author

DOI: 10.31083/j.rcm2308284 PMID: 39076631

09

Permissive role of Na+/H+ exchanger isoform 1 in migration and invasion of triple-negative basal-like breast cancer cells.

Li X, Fliegel L

Molecular and cellular biochemistry2022Senior author

DOI: 10.1007/s11010-022-04370-y PMID: 35084672

10

Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions.

Koltai T, Fliegel L

Journal of evidence-based integrative medicine2022Senior author

DOI: 10.1177/2515690x211068826 PMID: 35018864

Mechanism of Plasma Membrane Mediated Na+/H+ Exchange and Salt Tolerance in Plants, Animals and Yeast

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Fliegel, Larry

$198,000

Upgrade Advanced EPR/DEER Spectroscopy Facility

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Ernst, Oliver

$150,000

System for Resolving Native Membrane Nanodiscs and Protein Assemblies

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Overduin, Michael

$150,000

Molecular Analysis of Salt Tolerance Proteins

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Fliegel, Larry

$205,000

Protein Mediated Regulation of the Myocardial Na+/H+ Exchanger

Nominated PICIHR2014Operating Grant

Principal investigators: Fliegel, Larry

Keywords: Cardiovascular; Hypertrophy; Ischemia; Membrane Proteins; Protein Interactions; Signaling

$772,886

NSERC CREATE - International Research Training Group in Membrane Biology

Co-investigatorNSERC2012Collaborative Research and Training Experience

Principal investigators: Casey, Joseph

$1,492,665

Functional Characterization of the Na+/H+ Exchanger Protein

Nominated PICIHR2011Operating Grant

Principal investigators: Fliegel, Larry

Keywords: Cysteine Scanning Mutagenesis; Membrane Protein; Na+/H+ Exchanger; Protein Expression; Site Specific Mutagenesis

$746,967

Molecular analysis of salt tolerance proteins

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Fliegel, Larry

$230,000

Regulation of the Na+/H+ exchanger in the mammalian myocardium

Nominated PICIHR2009Operating Grant

Principal investigators: Fliegel, Larry

Keywords: Erk1/2; Intracellular Ph; Ischemia; Kinases; Na+H+ Exchanger; Phosphorylation

$812,749

Functional Characterization of the Na+/H+ Exchanger Protein

Nominated PICIHR2009Operating Grant - PA: Institute of Genetics (Bridge Funding)

Principal investigators: Fliegel, Larry

Keywords: Cysteine Scanning Mutagenesis; Membrane Protein; Na+/H+ Exchanger; Protein Expression; Site Specific Mutagenesis

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry
Chemistry
Pediatrics
Physiology and Pharmacology
Cell Biology and Anatomy
Other

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Howard Young

Biochemistry

2 shared papers, latest 2013

Samuel Weiss

Cell Biology and Anatomy

1 shared papers, latest 2012

Nicolas Touret

Biochemistry

1 shared papers, latest 2009

Morris Karmazyn

Physiology and Pharmacology

1 shared papers, latest 2022

Marek Michalak

Biochemistry

1 shared papers, latest 2013

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2020

Subject: Prospective PhD student: Cardiovascular Dear Professor Fliegel, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Anoikis: To Die or Not to Die?" (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Mechanism of Plasma Membrane Mediated Na+/H+ Exchange and Salt Tolerance in Plants, Animals and Yeast" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Larry Fliegel

Research

Latest papers

Latest funding

Anoikis: To Die or Not to Die?

Characterization of Critical Amino Acids in the Transport and Selectivity of the Plant Na+/H+ Exchanger Plasma Membrane SOS1.

Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts.

Exploring monocarboxylate transporter inhibition for cancer treatment.

The Relationship between Trop-2, Chemotherapeutic Drugs, and Chemoresistance.

Structure and Function of Membrane Proteins.

Acute SGLT-2i treatment improves cardiac efficiency during myocardial ischemia independent of Na+/H+ exchanger-1.

The Remaining Conundrum of the Role of the Na+/H+ Exchanger Isoform 1 (NHE1) in Cardiac Physiology and Pathology: Can It Be Rectified?

Permissive role of Na+/H+ exchanger isoform 1 in migration and invasion of triple-negative basal-like breast cancer cells.

Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions.

Mechanism of Plasma Membrane Mediated Na+/H+ Exchange and Salt Tolerance in Plants, Animals and Yeast

Upgrade Advanced EPR/DEER Spectroscopy Facility

System for Resolving Native Membrane Nanodiscs and Protein Assemblies

Molecular Analysis of Salt Tolerance Proteins

Protein Mediated Regulation of the Myocardial Na+/H+ Exchanger

NSERC CREATE - International Research Training Group in Membrane Biology

Functional Characterization of the Na+/H+ Exchanger Protein

Molecular analysis of salt tolerance proteins

Regulation of the Na+/H+ exchanger in the mammalian myocardium

Functional Characterization of the Na+/H+ Exchanger Protein

Frequent collaborators

Liang Li

Howard Young

Samuel Weiss

Nicolas Touret

Richard Fahlman

Gary Lopaschuk

Morris Karmazyn

Marek Michalak