Faculty profile

Gopinath Sutendra

ResearcherMedicineUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

Gopinath Sutendra

Researcher

Medicine

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
19 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Heart Failure P53 Apoptosis Susceptibility Dna Damage Mitochondria Oncology Paracrine Signalling Tumor-Secreted Factors

Latest papers

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.
Science translational medicine · 2026 · senior author
Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.
Circulation · 2026
Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.
Nature communications · 2026

All 51 publications

Latest funding

Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity
CIHR · 2022 · Nominated PI
$1,147,500
A Stress Activated Znf281 Signalling Pathway Can be Therapeutically Targeted to Prevent Chemotherapy-Induced Cardiotoxicity
CIHR · 2021 · Nominated PI
$956,250
Canada Research Chair - Tier 2
CIHR · 2021 · Nominated PI
$600,000

All 6 grants and awards

51 publications.

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.

Lorenzana-Carrillo MA, Tejay S, Huang G, Nanoa J, Zhao YY, Wagg C, Eaton F, Mendiola Pla M, Bowles DE, Kinnaird A, Michelakis ED, Tabatabaei Dakhili SA, Ussher JR, Sutendra G

Science translational medicine2026Senior author

DOI: 10.1126/scitranslmed.adz7727 PMID: 41984928

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

Zhang Y, Bonnet S, Provencher S, Piao J, Haromy A, Liu Y, Zhao YY, Breuils-Bonnet S, Lemay SE, Bowles DE, Mendiola Pla M, Sutendra G, Michelakis ED

Circulation2026

DOI: 10.1161/circulationaha.125.078674 PMID: 41797703

Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.

Piao J, Zhang Y, Zhao YY, Hanington P, Hambrook J, Liu Y, Ussher JR, Tabatabaei Dakhili SA, Sutendra G, Michelakis ED

Nature communications2026

DOI: 10.1038/s41467-026-74208-4 PMID: 42271149

Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation.

Chen R, Tabatabaei Dakhili SA, Gerulskis R, Zhao YY, Lockhart S, Tonoyan L, Siraki AG, Huang G, Kinnaird A, Freed DH, Minteer SD, Michelakis ED, Ussher JR, Sutendra G

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2025.110555 PMID: 40752580

Improving metabolic support during normothermic ex-situ heart perfusion.

Wagner MJ, Hatami S, Hassanzadeh P, Sutendra G, Conway J, Freed DH

Frontiers in cardiovascular medicine2025

DOI: 10.3389/fcvm.2025.1687255 PMID: 41561119

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents.

Tejay S, Lorenzana-Carrillo MA, Huang G, Tabatabaei Dakhili SA, Zhao Y-, Eaton F, Mendiola Pla M, Bowles DE, Kinnaird A, Paterson DI, Pituskin E, Ussher JR, Michelakis ED, Sutendra G

Nature communications2025Senior author

DOI: 10.1038/s41467-025-62172-4 PMID: 40715150

Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer's acute stress response.

Saleme B, Tejay S, Dembélé KP, Farraj RA, Zhang Y, Liu Y, Boukouris AE, Zervopoulos SD, Haromy A, Zhao YY, Braun S, Saleme W, Sun X, Fahlman RP, Glover M, Kinnaird A, Sutendra G, Michelakis ED

Cell reports2025

DOI: 10.1016/j.celrep.2025.115871 PMID: 40540400

Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI.

Huang G, Albers P, Mookerji N, Pfanner T, Hui A, Mittal R, Broomfield S, Dean L, St Martin B, Jacobsen NE, Evans H, Gao Y, Hung R, Abele J, Dromparis P, Lima JF, Bismar TA, Michelakis E, Sutendra G, Wuest F, Tu W, Adam BA, Fung C, Ghosh S, Tamm A, Kinnaird A, Next Generation Trial Investigators

European journal of nuclear medicine and molecular imaging2025

DOI: 10.1007/s00259-024-07021-0 PMID: 39725694

Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

Chan JSF, Tabatabaei Dakhili SA, Lorenzana-Carrillo MA, Gopal K, Pulente SM, Greenwell AA, Yang K, Saed CT, Stenlund MJ, Ferrari SR

Cell reports202417 citations

DOI: 10.1016/j.celrep.2024.114573

The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion.

Qi X, Hatami S, Bozso S, Wang X, Saleme B, Nagendran J, Michelakis E, Sutendra G, Freed DH

ASAIO journal (American Society for Artificial Internal Organs : 1992)2024

DOI: 10.1097/mat.0000000000002176 PMID: 38457627

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Heart Failure Dear Professor Sutendra, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Gopinath Sutendra

Research

Latest papers

Latest funding

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.

Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation.

Improving metabolic support during normothermic ex-situ heart perfusion.

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents.

Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer's acute stress response.

Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI.

Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion.

Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity

A Stress Activated Znf281 Signalling Pathway Can be Therapeutically Targeted to Prevent Chemotherapy-Induced Cardiotoxicity

Canada Research Chair - Tier 2

Optimization of a device for preservation and evaluation of donor hearts while functioning_x000d_ external to the body, in preparation for transplant

Optimization of an ex vivo heart perfusion device for pre-transplant preservation and evaluation of donor hearts

Activation of Pyruvate Kinase M2 as a Novel Therapy for Chemotherapy-Induced Cardiotoxicity

Frequent collaborators

Steeve Provencher

Edith Pituskin

Evangelos Michelakis

Sébastien Bonnet

Frank Wuest

Roxane Paulin

Ian Paterson

Olivier Boucherat

Marek Michalak

Spencer Proctor

Gregory Steinberg

Ronald Moore

Gopinath Sutendra

Research

Latest papers

Latest funding

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.

Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation.

Improving metabolic support during normothermic ex-situ heart perfusion.

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents.

Hyperacute response proteins synthesized on &#x3b3;-tubulin-FTO-MARK4 translation microdomains regulate cancer's acute stress response.

Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI.

Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart Perfusion.

Tumor-Secreted Nucleosides Can Promote RbFox1 Degradation and Signalling Pathways Relevant to Dedifferentiation in Cardiomyocytes; A Two-Hit Hypothesis with Implications for Cardiotoxicity

A Stress Activated Znf281 Signalling Pathway Can be Therapeutically Targeted to Prevent Chemotherapy-Induced Cardiotoxicity

Canada Research Chair - Tier 2

Optimization of a device for preservation and evaluation of donor hearts while functioning_x000d_ external to the body, in preparation for transplant

Optimization of an ex vivo heart perfusion device for pre-transplant preservation and evaluation of donor hearts

Activation of Pyruvate Kinase M2 as a Novel Therapy for Chemotherapy-Induced Cardiotoxicity

Frequent collaborators

Steeve Provencher

Edith Pituskin

Evangelos Michelakis

Sébastien Bonnet

Frank Wuest

Roxane Paulin

Ian Paterson

Olivier Boucherat

Marek Michalak

Spencer Proctor

Gregory Steinberg

Ronald Moore

Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer's acute stress response.