Paul Jurasz, University of Alberta

Research

Endothelial Nitric Oxide Synthase Flow Cytometry Nitric Oxide Aggregometry Fluorescence Activated Cell Sorting Fluorescence Microscopy Platelet Pharmacology Platelet Subpopulations

Latest papers

The association of angiostatin and plasminogen plasma levels with Charlson comorbidity burden and mortality in COVID-19.
Journal of thrombosis and thrombolysis · 2026 · senior author
Angiostatin-a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology.
Journal of thrombosis and haemostasis : JTH · 2025 · senior author
Loading-Controlled Zymography.
Methods in molecular biology (Clifton, N.J.) · 2025 · senior author

All 31 publications

Latest funding

Pharmacological Characterization of eNOS-based Platelet Subpopulations
CIHR · 2018 · Nominated PI
$623,475
Characterization of Platelet Subpopulations based on the Heterogeneity of NOS Signaling: Significance for Hemostasis and Thrombosis
CIHR · 2013 · Nominated PI
$438,527
Characterization of Platelet Subpopulations based on the Heterogeneity of NOS Signaling: Significance for Hemostasis and Thrombosis
CIHR · 2012 · Nominated PI
$100,000

All 4 grants and awards

31 publications.

01

The association of angiostatin and plasminogen plasma levels with Charlson comorbidity burden and mortality in COVID-19.

Franczak A, Calistrate-Petre P, Dinu I, Jurasz P

Journal of thrombosis and thrombolysis2026Senior author

DOI: 10.1007/s11239-026-03289-1 PMID: 42149301

02

Angiostatin-a novel SARS-CoV-2 inhibitor and biomarker underlying COVID-19 pathophysiology.

Franczak A, Joyce M, Lopez-Orozco J, Saffran HA, Saito M, Asgari A, Kalyaanamoorthy S, Barakat K, Hobman TC, Tyrrell DL, Jurasz P

Journal of thrombosis and haemostasis : JTH2025Senior author

DOI: 10.1016/j.jtha.2025.03.030 PMID: 40199448

03

Loading-Controlled Zymography.

Franczak A, Jurasz P

Methods in molecular biology (Clifton, N.J.)2025Senior author

DOI: 10.1007/978-1-0716-4478-2_17 PMID: 40347343

04

Elevated levels of pro-thrombotic eNOS-negative platelets in COVID-19 patients.

Asgari A, Franczak A, Herchen A, Jickling GC, Jurasz P

Thrombosis research2024Senior author

DOI: 10.1016/j.thromres.2024.109178 PMID: 39369655

05

Role of Nitric Oxide in Megakaryocyte Function.

Asgari A, Jurasz P

International journal of molecular sciences2023Senior author

DOI: 10.3390/ijms24098145 PMID: 37175857

06

Inhibition of platelet aggregation by activation of platelet intermediate conductance Ca2+ -activated potassium channels.

Back V, Asgari A, Franczak A, Saito M, Castaneda Zaragoza D, Sandow SL, Plane F, Jurasz P

Journal of thrombosis and haemostasis : JTH2022Senior author

DOI: 10.1111/jth.15827 PMID: 35867883

07

Editorial: Established and Novel Roles of Platelets in Health and Disease.

Jurasz P, Ignjatovic V, Lordkipanidzé M

Frontiers in cardiovascular medicine2022First author

DOI: 10.3389/fcvm.2022.835615 PMID: 35174235

08

Platelets stimulate programmed death-ligand 1 expression by cancer cells: Inhibition by anti-platelet drugs.

Asgari A, Lesyk G, Poitras E, Govindasamy N, Terry K, To R, Back V, Rudzinski JK, Lewis JD, Jurasz P

Journal of thrombosis and haemostasis : JTH2021Senior author

DOI: 10.1111/jth.15478 PMID: 34333838

09

Preferential interaction of platelets with prostate cancer cells with stem cell markers.

Rudzinski JK, Govindasamy NP, Asgari A, Saito MS, Lewis JD, Jurasz P

Thrombosis research2021Senior author

DOI: 10.1016/j.thromres.2021.08.008 PMID: 34403851

10

L-Arginine and NOS activity, a complex relationship.

Le Melledo JM, Baker G, Gyenes G, Tsuyuki R, Jurasz P

Psychopharmacology2021Senior author

DOI: 10.1007/s00213-021-05799-7 PMID: 33595692

Pharmacological Characterization of eNOS-based Platelet Subpopulations

Nominated PICIHR2018Project Grant

Principal investigators: Jurasz, Paul K

Keywords: Anti-Platelet Drugs; Endothelial Nitric Oxide Synthase; Flow Cytometry; Matrix Metalloproteinases; Myocardial Infarction; Nitric Oxide; Pharmacology; Platelet Function Testing; Platelets; Prognostic Biomarkers

$623,475

Characterization of Platelet Subpopulations based on the Heterogeneity of NOS Signaling: Significance for Hemostasis and Thrombosis

Nominated PICIHR2013Operating Grant

Principal investigators: Jurasz, Paul K

Keywords: Aggregometry; Endothelial Nitric Oxide Synthase; Flow Cytometry; Fluorescence Activated Cell Sorting; Fluorescence Microscopy; Nitric Oxide; Platelet Pharmacology; Platelet Subpopulations; Quartz Crystal Microbalance Flow Assay; Stroke Patients

$438,527

Characterization of Platelet Subpopulations based on the Heterogeneity of NOS Signaling: Significance for Hemostasis and Thrombosis

Nominated PICIHR2012Operating Grant - PA: ICRH - New investigators (Bridge Funding)

Principal investigators: Jurasz, Paul K

Keywords: Aggregometry; Endothelial Nitric Oxide Synthase; Flow Cytometry; Fluorescence Activated Cell Sorting; Fluorescence Microscopy; Nitric Oxide; Platelet Pharmacology; Platelet Subpopulations; Quartz Crystal Microbalance Flow Assay; Stroke Patients

$100,000

Role of Platelets in Angiogenesis: Selective PKC Inhibition Uncouples Platelet Hemostasis from Angiogenesis Promotion

Nominated PICIHR2009Operating Grant - PA: Cancer Research (bridge funding)

Principal investigators: Jurasz, Paul K

Keywords: Aggregometry; Alpha-Granules; Angiogenesis; Flow Cytometry; Platelets; Protein Kinase C

$79,345

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pharmacy and Pharmaceutical Sciences
Medicine/Cardiology
Oncology
Medicine/Nephrology
Other

Applying for

Paper to mention

Subject: Prospective PhD student: Endothelial Nitric Oxide Synthase Dear Professor Jurasz, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The association of angiostatin and plasminogen plasma levels with Charlson comorbidity burden and mortality in COVID-19." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]