Faculty profile

Thomas Simmen

ResearcherCell BiologyUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

Thomas Simmen

Researcher

Cell Biology

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (5 CIHR, 3 NSERC), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Endoplasmic Reticulum Mitochondria Bioenergetics Metabolism Neurological Defects Redox Biology Oncogenes Supressors

Latest papers

ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics.
Nature cell biology · 2026
Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice.
Anesthesiology · 2025
A lipid in transit - the journey of cholesterol into the heart of mitochondrial research.
Journal of cell science · 2025 · first author

All 59 publications

Latest funding

The TMX2 Redox Web as a Paradigm for Endoplasmic Reticulum-Mitochondria Contact Site (ERMCS) Pathologies
CIHR · 2024 · Nominated PI
$971,550
Rab32 Promotes Autophagic Elimination of a Metabolism Control Center in Breast Cancer
CIHR · 2021 · Nominated PI
$60,000
The endoplasmic reticulum (ER) as a key regulator of metabolism
NSERC · 2021 · Principal investigator
$168,000

All 11 grants and awards

59 publications.

ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics.

Bassot A, Violy L, Gorka L, Cigalotto L, Namasivayam B, Mikaelian I, St Johnston E, Han C, Gadet R, Alpha-Bazin B, Moindrot L, Clement E, Dragic H, Crépin M, Berdeaux O, Vanbelle C, Gautier M, Cariou A, Larrouquere L, Wei C, Gudermann T, Sarkaria JN, Zito E, Dietrich PY, Walker PR, Nemazanyy I, Lincet H, Armengaud J, Rieusset J, Mischel PS, Mammadova-Bach E, Simmen T, Martinvalet D, Castets M, Cosset E

Nature cell biology2026

DOI: 10.1038/s41556-026-01980-2 PMID: 42286227

Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice.

Maguire AD, Lamothe SM, Yousuf MS, Goss K, Rao J, Tenorio G, Kaulagari SR, Hazlehurst L, Plemel JR, Taylor AMW, Kurata HT, Simmen T, Kerr BJ

Anesthesiology2025

DOI: 10.1097/aln.0000000000005453 PMID: 40106735

A lipid in transit - the journey of cholesterol into the heart of mitochondrial research.

Simmen T, Pellegrini L

Journal of cell science2025First author

DOI: 10.1242/jcs.263907 PMID: 40337919

The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.

Chen J, Yap MC, Bassot A, Pascual DM, Makio T, Zimmermann J, Mast H, Bhat R, Fleury SG, Fan Y, Buzatto AZ, Moore J, Ballanyi K, Li L, Overduin M, Lemieux MJ, Lemieux H, Mancini GMS, Morgan B, Marcogliese PC, Simmen T

Cell reports2025Senior author

DOI: 10.1016/j.celrep.2025.116486 PMID: 41175374

MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α.

Bassiouni W, Mahmud Z, Simmen T, Seubert JM, Schulz R

Journal of molecular and cellular cardiology2025

DOI: 10.1016/j.yjmcc.2024.11.013 PMID: 39622369

ER stress as a sentinel mechanism for ER Ca2+ homeostasis.

Makio T, Chen J, Simmen T

Cell calcium2024Senior author

DOI: 10.1016/j.ceca.2024.102961 PMID: 39471738

Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering.

Makio T, Simmen T

Contact (Thousand Oaks (Ventura County, Calif.))2024Senior author

DOI: 10.1177/25152564241261228 PMID: 39070058

Ironing out the mitochondria.

Chen J, Makio T, Simmen T

Nature chemical biology2024Senior author

DOI: 10.1038/s41589-023-01509-w PMID: 38212577

SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.

Germani S, Van Ho AT, Cherubini A, Varone E, Chernorudskiy A, Renna GM, Fumagalli S, Gobbi M, Lucchetti J, Bolis M, Guarrera L, Craparotta I, Rastelli G, Piccoli G, de Napoli C, Nogara L, Poggio E, Brini M, Cattaneo A, Bachi A, Simmen T, Calì T, Quijano-Roy S, Boncompagni S, Blaauw B, Ferreiro A, Zito E

Cell reports. Medicine2024

DOI: 10.1016/j.xcrm.2024.101439 PMID: 38402623

Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca2+ dynamics linked to DEE66.

Thi My Nhung T, Phuoc Long N, Diem Nghi T, Suh Y, Hoang Anh N, Jung CW, Minh Triet H, Jung M, Woo Y, Yoo J, Noh S, Kim SJ, Lee SB, Park S, Thomas G, Simmen T, Mun J, Rhee HW, Kwon SW, Park SK

Proceedings of the National Academy of Sciences of the United States of America2023

DOI: 10.1073/pnas.2303402120 PMID: 37523531

The TMX2 Redox Web as a Paradigm for Endoplasmic Reticulum-Mitochondria Contact Site (ERMCS) Pathologies

Nominated PICIHR2024Project Grant

Principal investigators: Simmen, Thomas

Keywords: Bioenergetics; Endoplasmic Reticulum; Metabolism; Mitochondria; Neurological Defects; Redox Biology

$971,550

Rab32 Promotes Autophagic Elimination of a Metabolism Control Center in Breast Cancer

Nominated PICIHR2021CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Simmen, Thomas

Keywords: Oncogenes; Supressors; Tumour

$60,000

The endoplasmic reticulum (ER) as a key regulator of metabolism

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Simmen, Thomas

$168,000

Understanding the contribution of the peripheral nervous system to central neuropathic pain

Co-investigatorCIHR2018Project Grant

Principal investigators: Kerr, Bradley

Keywords: Anti-Oxidant; Cytokine; Drg; Er Stress; Exercise; Inflammation; Mitochondria; Multiple Sclerosis; Pain; Ros

$669,375

Revisiting the Mitochondria-Associated Membrane: Redox Controls Tethers

Nominated PICIHR2018Project Grant

Principal investigators: Simmen, Thomas

Keywords: Endoplasmic Reticulum; Mitochondria; Oxidative Stress

$799,425

Membrane Contact Sites in Health and Disease

Nominated PICIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Simmen, Thomas

Keywords: International Meeting

$11,715

High-resolution quantitative fluorescence detection systems

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Eitzen, Gary

$84,452

Exploring Endoplasmic Reticulum-Associated Rab GTPases

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Simmen, Thomas

$170,000

Stress-Dependent Regulation of Mitochondria-ER Membrane Dynamics by Rab32 in Neuroinflammation

Nominated PICIHR2013Operating Grant

Principal investigators: Simmen, Thomas

Keywords: Endoplasmic Reticulum; Mitochondria; Multiple Sclerosis; Neuroinflammation; Secretion; Signaling

$704,629

Role of intracellular trafficking mediators in mitochondria membrane dynamics

Principal investigatorNSERC2010Discovery Grants Program - Group

Principal investigators: Simmen, Thomas

$165,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Thomas Simmen

Research

Latest papers

Latest funding

ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics.

Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice.

A lipid in transit - the journey of cholesterol into the heart of mitochondrial research.

The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.

MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α.

ER stress as a sentinel mechanism for ER Ca2+ homeostasis.

Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering.

Ironing out the mitochondria.

SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.

Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca2+ dynamics linked to DEE66.

The TMX2 Redox Web as a Paradigm for Endoplasmic Reticulum-Mitochondria Contact Site (ERMCS) Pathologies

Rab32 Promotes Autophagic Elimination of a Metabolism Control Center in Breast Cancer

The endoplasmic reticulum (ER) as a key regulator of metabolism

Understanding the contribution of the peripheral nervous system to central neuropathic pain

Revisiting the Mitochondria-Associated Membrane: Redox Controls Tethers

Membrane Contact Sites in Health and Disease

High-resolution quantitative fluorescence detection systems

Exploring Endoplasmic Reticulum-Associated Rab GTPases

Stress-Dependent Regulation of Mitochondria-ER Membrane Dynamics by Rab32 in Neuroinflammation

Role of intracellular trafficking mediators in mitochondria membrane dynamics

Frequent collaborators

Fabrizio Giuliani

Richard Schulz

Michael Zaugg

Christopher Power

Luca Pellegrini

Nicolas Touret

Liang Li

Mahmoud Ali

Thomas Simmen

Research

Latest papers

Latest funding

ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics.

Inhibition of Endoplasmic Reticulum Oxidoreductin 1 Modulates Neuronal Excitability and Nociceptive Sensitivity in Mice.

A lipid in transit - the journey of cholesterol into the heart of mitochondrial research.

The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.

MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1&#x3b1;.

ER stress as a sentinel mechanism for ER Ca2+ homeostasis.

Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering.

Ironing out the mitochondria.

SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.

Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca2+ dynamics linked to DEE66.

The TMX2 Redox Web as a Paradigm for Endoplasmic Reticulum-Mitochondria Contact Site (ERMCS) Pathologies

Rab32 Promotes Autophagic Elimination of a Metabolism Control Center in Breast Cancer

The endoplasmic reticulum (ER) as a key regulator of metabolism

Understanding the contribution of the peripheral nervous system to central neuropathic pain

Revisiting the Mitochondria-Associated Membrane: Redox Controls Tethers

Membrane Contact Sites in Health and Disease

High-resolution quantitative fluorescence detection systems

Exploring Endoplasmic Reticulum-Associated Rab GTPases

Stress-Dependent Regulation of Mitochondria-ER Membrane Dynamics by Rab32 in Neuroinflammation

Role of intracellular trafficking mediators in mitochondria membrane dynamics

Frequent collaborators

Fabrizio Giuliani

Richard Schulz

Michael Zaugg

Christopher Power

Luca Pellegrini

Nicolas Touret

Liang Li

Mahmoud Ali

MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1α.