Research
Read how they describe their research on their University of Alberta profile.
Latest papers
Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice.
Acta neuropathologica communications · 2021
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology.
Disease models & mechanisms · 2021
Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease.
Molecular neurobiology · 2021
Latest funding
- $50,000
Amyloid beta oligomers: refining the therapeutic target through photolabelling and fractionation
BRAIN · 2024 · Principal investigator
- $400,000
Infrastructure for studying both the biophysics of infectious prion oligomers and the prion disease pathology they induce.
CFI · 2010 · Principal investigator
8 publications.
Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice.
Ali T, Hannaoui S, Nemani S, Tahir W, Zemlyankina I, Cherry P, Shim SY, Sim V, Schaetzl HM, Gilch S
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology.
Wu Q, Cortez L, Kamali-Jamil R, Sim V, Wille H, Kar S
Quaternary Structure Changes for PrPSc Predate PrPC Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease.
Eskandari-Sedighi G, Cortez LM, Yang J, Daude N, Shmeit K, Sim V, Westaway D
TREM2 expression in the brain and biological fluids in prion diseases.
Diaz-Lucena D, Kruse N, Thüne K, Schmitz M, Villar-Piqué A, da Cunha JEG, Hermann P, López-Pérez Ó, Andrés-Benito P, Ladogana A, Calero M, Vidal E, Riggert J, Pineau H, Sim V, Zetterberg H, Blennow K, Del Río JA, Marín-Moreno A, Espinosa JC, Torres JM, Sánchez-Valle R, Mollenhauer B, Ferrer I, Zerr I, Llorens F
POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research.
Pineau H, Sim V
14-3-3 and enolase abundances in the CSF of Prion diseased rats.
Gushue D, Herbst A, Sim V, McKenzie D, Aiken JM
Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie.
Wolf H, Hossinger A, Fehlinger A, Büttner S, Sim V, McKenzie D, Vorberg IM
The therapeutic potential of chemical chaperones in protein folding diseases.
Cortez L, Sim V
Amyloid beta oligomers: refining the therapeutic target through photolabelling and fractionation
Principal investigators: Sim, Valerie
Keywords: Neurodegeneration; Alzheimer's
Infrastructure for studying both the biophysics of infectious prion oligomers and the prion disease pathology they induce.
Principal investigators: Sim, Valerie
Keywords: prion, pathogenesis, biophysics, oligomer, confocal microscopy, cell culture
From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.
Frequent collaborators
- Satyabrata Kar and S Kar: 144 shared papers
- Holger Wille and Debbie McKenzie: 8 shared papers
- Satyabrata Kar and Holger Wille: 7 shared papers
- Holger Wille and S Kar: 7 shared papers
- Sabine Gilch and Debbie McKenzie: 6 shared papers
- Holger Wille and Sabine Gilch: 3 shared papers
- Sabine Gilch and Hermann Schaetzl: 2 shared papers
- Debbie McKenzie and Valerie Sim: 2 shared papers
- Satyabrata Kar and Valerie Sim: 1 shared paper
- Holger Wille and Valerie Sim: 1 shared paper
- Sabine Gilch and Valerie Sim: 1 shared paper
- Hermann Schaetzl and Valerie Sim: 1 shared paper
- S Kar and Valerie Sim: 1 shared paper
- Medicine Dept
- Biological Sciences
- Comparative Biology & Experimental Medicine
- Biochemistry Dept
- Veterinary Medicine, Faculty of
- Medicine/Neurology
Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Debbie McKenzie
Biological Sciences
2 shared papers, latest 2018
David Westaway
Medicine
1 shared papers, latest 2021
Holger Wille
Biochemistry Dept
1 shared papers, latest 2021
Sabine Gilch
Veterinary Medicine, Faculty of
1 shared papers, latest 2021
Hermann Schaetzl
Comparative Biology & Experimental Medicine
1 shared papers, latest 2021
Judd Aiken
Faculty
1 shared papers, latest 2018
Satyabrata Kar
Medicine/Neurology
1 shared papers, latest 2021
S Kar
Medicine Dept
1 shared papers, latest 2021
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Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.