Faculty profile

Holger Wille

ResearcherBiochemistryUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

Holger Wille

Researcher

Biochemistry

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
22 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 1 research grant (1 CIHR), most recently in 2014.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Electron Microscopy Familial Creutzfeldt-Jakob Disease Fatal Familial Insomnia Gerstmann-Straussler-Scheinker Syndrome High Throughput Screening Immunotherapy In Vivo Studies Monoclonal Antibodies

Latest papers

Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease.
Brain : a journal of neurology · 2026
A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.
Acta neuropathologica · 2026 · senior author
A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.
PLoS pathogens · 2026

All 64 publications

Latest funding

Biodegradable acidic nanoparticles attenuate beta-amyloid aggregation/toxicity: potential implication in the treatment of Alzheimer's disease pathology
CIHR · 2021 · Co-investigator
$730,576
A comprehensive approach to halt chronic wasting disease transmission
NSERC · 2021 · Co-investigator
$1,472,160
Cross-Disciplinary Nanoplasmonics-Enabled Platform for Characterization and Analysis of Biomolecular Condensates
SSHRC · 2021 · Co-investigator
$250,000

All 4 grants and awards

64 publications.

Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease.

Ma L, Reithofer S, Pesch V, Flores-Fernandez JM, Sriraman A, Duckering C, Amidian S, Özdüzenciler P, Müller L, Wille H, Tamgüney G

Brain : a journal of neurology2026

DOI: 10.1093/brain/awag010 PMID: 41512110

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

Fang A, Tang X, Fleming M, Tancowny B, Wang X, Wang Y, Daude N, Dorosh L, Fleck SC, Rathod V, Coustou V, Cervantes SA, Velásquez CD, Westaway D, Aiken J, McKenzie D, Telling G, Stepanova M, Saupe SJ, Siemer AB, Wille H

Acta neuropathologica2026Senior author

DOI: 10.1007/s00401-026-03015-4 PMID: 41995880

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

Zerbes T, Verkuyl C, Zhang C, Grunnesjoe S, Eid S, Arshad H, Zhao W, Nasser Z, O'Shea T, Bel A, Lamoureux L, Frost KL, Myskiw J, Li LY, Stuart E, Wille H, Booth S, Watts JC, Schmitt-Ulms G

PLoS pathogens2026

DOI: 10.1371/journal.ppat.1014124 PMID: 42550881

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

Zerbes T, Verkuyl C, Zhang C, Grunnesjoe S, Eid S, Arshad H, Zhao W, Nasser Z, O'Shea T, Belotserkovsky A, Lamoureux L, Frost KL, Myskiw J, Li L, Stuart E, Wille H, Booth S, Watts JC, Schmitt-Ulms G

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.03.27.714700 PMID: 41929092

Plasmonics-Enhanced Characterization of Cervid PrP (87-114) Fragment Aggregates in Solution.

Midha S, Sriraman A, Dorosh L, Wille H, Stepanova M

Journal of biophotonics2026

DOI: 10.1002/jbio.202500428 PMID: 41292430

Multiscale simulations of folded and intrinsically disordered region-containing protein condensates.

Dorosh L, Wille H, Stepanova M

Biophysical journal2026

DOI: 10.1016/j.bpj.2025.10.018 PMID: 41088757

Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions.

Paul PS, Rathnam M, Khalili A, Cortez LM, Srinivasan M, Planel E, Cho JY, Wille H, Sim VL, Mok SA, Kar S

International journal of nanomedicine2025

DOI: 10.2147/ijn.s494104 PMID: 39968061

A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases.

Schmitt-Ulms G, Wang X, Watts J, Booth S, Wille H, Zhao W

ArXiv2025

DOI: 10.1101/2024.12.18.629254 PMID: 39876936

Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs

Overduin M, Kuyler GC, Esmaili M, Trieber CA, Acevedo-Morantes C, Orazietti AP, Shaykhutdinov R, Bhat RK, Omotoso T, Tajammul S

Biophysical Chemistry20256 citations

DOI: 10.1016/j.bpc.2025.107489

Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology.

Paul PS, Patel T, Cho JY, Yarahmady A, Khalili A, Semenchenko V, Wille H, Kulka M, Mok SA, Kar S

Scientific reports2024

DOI: 10.1038/s41598-023-50465-x PMID: 38167993

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Holger Wille

Research

Latest papers

Latest funding

Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease.

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

Plasmonics-Enhanced Characterization of Cervid PrP (87-114) Fragment Aggregates in Solution.

Multiscale simulations of folded and intrinsically disordered region-containing protein condensates.

Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions.

A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases.

Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs

Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology.

Biodegradable acidic nanoparticles attenuate beta-amyloid aggregation/toxicity: potential implication in the treatment of Alzheimer's disease pathology

A comprehensive approach to halt chronic wasting disease transmission

Cross-Disciplinary Nanoplasmonics-Enabled Platform for Characterization and Analysis of Biomolecular Condensates

Immunotherapy of familial prion diseases

Frequent collaborators

Gerold Schmitt-Ulms

David Westaway

Satyabrata Kar

Sabine Gilch

Stephanie Booth

Sue-Ann Mok

Simon Sharpe

Richard Fahlman

Angus Lau

Fabrizio Giuliani

Jasna Kriz

Anurag Tandon

Emmanuel Planel

Russell Bishop

Joel Watts

Holger Wille

Research

Latest papers

Latest funding

Vaccines mimicking conformational epitopes on &#x3b1;-synuclein fibrils provide immunity to Parkinson's disease.

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Str&#xe4;ussler-Scheinker disease mutation.

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

Plasmonics-Enhanced Characterization of Cervid PrP (87-114) Fragment Aggregates in Solution.

Multiscale simulations of folded and intrinsically disordered region-containing protein condensates.

Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions.

A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases.

Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs

Native PLGA nanoparticles attenuate A&#x3b2;-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology.

Biodegradable acidic nanoparticles attenuate beta-amyloid aggregation/toxicity: potential implication in the treatment of Alzheimer's disease pathology

A comprehensive approach to halt chronic wasting disease transmission

Cross-Disciplinary Nanoplasmonics-Enabled Platform for Characterization and Analysis of Biomolecular Condensates

Immunotherapy of familial prion diseases

Frequent collaborators

Gerold Schmitt-Ulms

David Westaway

Satyabrata Kar

Sabine Gilch

Stephanie Booth

Sue-Ann Mok

Simon Sharpe

Richard Fahlman

Angus Lau

Fabrizio Giuliani

Jasna Kriz

Anurag Tandon

Emmanuel Planel

Russell Bishop

Joel Watts

Vaccines mimicking conformational epitopes on α-synuclein fibrils provide immunity to Parkinson's disease.

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.

Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology.