Matthias Amrein, University of Calgary

Research

Alveolar Epithelium Alveolar Macrophage Cell Culture E-Liquids Fibrosis Histology Immunohistochemistry Lung Injury

Latest papers

Effects of pirfenidone and fisetin on apoptosis and oxidative stress mechanisms in heart tissue of bleomycin-induced pulmonary fibrosis.
Journal of molecular histology · 2026
Single-cell vibration analysis for potential diagnostic applications.
Biophysical reports · 2026 · senior author
Comparing Imaging Depth of Intravital Lung Imaging Using Perfluorocarbon-Based Liquid Ventilation With Tissue Clearing for Deep-Tissue Imaging.
Journal of biophotonics · 2026 · senior author

All 27 publications

Latest funding

Determining the Molecular Mechanisms of Skeletal Muscle Contraction and Force Production by Combining Nano-Mechanics, Fluorescent Antibody Labeling, and High Resolution Cryo-Electron Tomography
CIHR · 2025 · Co-investigator
$1,113,075
Highly Dexterous Robotic Endoscope for Improved Access to Minimally Invasive Surgery and Diagnostics
SSHRC · 2024 · Principal investigator
$125,000
Glow Discharger and Vitrification Robot for Cryo-EM Studies
NSERC · 2024 · Co-investigator
$114,407

All 9 grants and awards

27 publications.

01

Effects of pirfenidone and fisetin on apoptosis and oxidative stress mechanisms in heart tissue of bleomycin-induced pulmonary fibrosis.

Yıldırım AB, Göl M, Çimen L, Yiğin A, Amrein M, Küçükhüyük Ş

Journal of molecular histology2026

DOI: 10.1007/s10735-026-10784-5 PMID: 41961361

02

Single-cell vibration analysis for potential diagnostic applications.

Topham JJ, Al-Khaz'Aly A, Ghandorah S, Parikh T, Farshidfar F, Amrein M

Biophysical reports2026Senior author

DOI: 10.1016/j.bpr.2026.100252 PMID: 41548874

03

Comparing Imaging Depth of Intravital Lung Imaging Using Perfluorocarbon-Based Liquid Ventilation With Tissue Clearing for Deep-Tissue Imaging.

Detampel P, Heusermann W, Wojcik KM, Yipp BG, Amrein M

Journal of biophotonics2026Senior author

DOI: 10.1002/jbio.202500145 PMID: 40899148

04

A comprehensive method to analyze single-cell vibrations.

Al-Khaz'Aly A, Ghandorah S, Topham JJ, Osman N, Louie T, Farshidfar F, Amrein M

Biophysical journal2025Senior author

DOI: 10.1016/j.bpj.2024.11.003 PMID: 39506334

05

Pulmonary surfactant function and molecular architecture is disrupted in the presence of vaping additives.

Van Bavel N, Lai P, Amrein M, Prenner EJ

Colloids and surfaces. B, Biointerfaces2023

DOI: 10.1016/j.colsurfb.2023.113132 PMID: 36630771

06

Caveolin-initiated macropinocytosis is required for efficient silica nanoparticles' transcytosis across the alveolar epithelial barrier.

Detampel P, Tehranian S, Mukherjee P, Foret M, Fuerstenhaupt T, Darbandi A, Bogari N, Hlasny M, Jeje A, Olszewski MA, Ganguly A, Amrein M

Scientific reports2022Senior author

DOI: 10.1038/s41598-022-13388-7 PMID: 35676405

07

Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis.

Neupane AS, Willson M, Chojnacki AK, Vargas E Silva Castanheira F, Morehouse C, Carestia A, Keller AE, Peiseler M, DiGiandomenico A, Kelly MM, Amrein M, Jenne C, Thanabalasuriar A, Kubes P

Cell2020

DOI: 10.1016/j.cell.2020.08.020 PMID: 32888431

08

Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-κB inflammatory signaling pathway in human skin cells.

Altonsy MO, Kurwa HA, Lauzon GJ, Amrein M, Gerber AN, Almishri W, Mydlarski PR

Immunity, inflammation and disease2020

DOI: 10.1002/iid3.284 PMID: 31912662

09

Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).

Altonsy MO, Ganguly A, Amrein M, Surmanowicz P, Li SS, Lauzon GJ, Mydlarski PR

International journal of molecular sciences2020

DOI: 10.3390/ijms21051656 PMID: 32121295

10

Dysfunction of pulmonary surfactant mediated by phospholipid oxidation is cholesterol-dependent.

Al-Saiedy M, Pratt R, Lai P, Kerek E, Joyce H, Prenner E, Green F, Ling CC, Veldhuizen R, Ghandorah S, Amrein M

Biochimica et biophysica acta. General subjects2018Senior author

DOI: 10.1016/j.bbagen.2018.01.008 PMID: 29413906

Determining the Molecular Mechanisms of Skeletal Muscle Contraction and Force Production by Combining Nano-Mechanics, Fluorescent Antibody Labeling, and High Resolution Cryo-Electron Tomography

Co-investigatorCIHR2025Project Grant

Principal investigators: Herzog, Walter

Keywords: Actin; Antibody Labelling; Fluorescent Microscopy; High Resolution Cryo-Electron Tomography; Molecular Mechanisms Of Muscle Contraction; Myosin; Single Myofibril Mechanics; Single Protein Mechanics; Single Sarcomere Mechanics; Titin

$1,113,075

Highly Dexterous Robotic Endoscope for Improved Access to Minimally Invasive Surgery and Diagnostics

Principal investigatorSSHRC2024New Frontiers in Research Fund - Exploration

Principal investigators: Amrein, Matthias

$125,000

Glow Discharger and Vitrification Robot for Cryo-EM Studies

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Haji-Ghassemi, Omid

Keywords: cryo-EM; Electron Microscopy; Enzymology; Glow discharge; Nanoparticles; Phage Biology; Proteins; Structural Biology; Tomography; Vitrification

$114,407

The pathogenesis of vaping-associated lung injury: interactions between the alveolar epithelium and the immune system

Principal investigatorCIHR2020Catalyst Grant: Health Effects of Vaping

Principal investigators: Kelly, Margaret M; Anselmo, Mark A; Amrein, Matthias W; Gillrie, Mark R; Proud, David

Keywords: Alveolar Epithelium; Alveolar Macrophage; Cell Culture; E-Liquids; Fibrosis; Histology; Immunohistochemistry; Lung Injury; Surfactant; Vaping

$99,280

Cell and Tissue Vibrations

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Amrein, Matthias

$252,000

Cell- and Tissue Vibrations

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Amrein, Matthias

$28,000

Single Chain Antibodies to Probe the Molecular Basis of Epigenetics In Living Cells.

Co-investigatorCIHR2011Catalyst Grant - CEEHRC Epigenetics, Environment & Health

Principal investigators: Riabowol, Karl T

Keywords: Chromatin; Epigenetics; Immunofluorescence; Ing Proteins; Rna Polymerase; Single Cell; Single Chain Antibodies

$97,470

Biophysical basis of single cell force spectroscopy

Co-investigatorNSERC2010Discovery Grants Program - Group

Principal investigators: Shi, Yan

$330,000

Biophysical basis of single cell force spectroscopy

Co-investigatorNSERC2010Discovery Grants Program - Accelerator Supplements

Principal investigators: Shi, Yan

$120,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Pathology and Laboratory Medicine
Physiology and Pharmacology
Human Performance Laboratory
Surgery
Microbiology and Infectious Diseases

Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Paul Kubes

Physiology and Pharmacology

2 shared papers, latest 2020

Walter Herzog

Human Performance Laboratory

2 shared papers, latest 2013

Pere Santamaria

Microbiology and Infectious Diseases

1 shared papers, latest 2017

Craig Jenne

Medicine

1 shared papers, latest 2020

John Conly

Medicine

1 shared papers, latest 2016

Mary Brindle

Surgery

1 shared papers, latest 2017

Ajitha Thanabalasuriar

Medicine

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their SSHRC grant from 2024

Subject: Prospective PhD student: Alveolar Epithelium Dear Professor Amrein, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Effects of pirfenidone and fisetin on apoptosis and oxidative stress mechanisms in heart tissue of bleomycin-induced pulmonary fibrosis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your SSHRC-funded project "Highly Dexterous Robotic Endoscope for Improved Access to Minimally Invasive Surgery and Diagnostics" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Matthias Amrein

Research

Latest papers

Latest funding

Effects of pirfenidone and fisetin on apoptosis and oxidative stress mechanisms in heart tissue of bleomycin-induced pulmonary fibrosis.

Single-cell vibration analysis for potential diagnostic applications.

Comparing Imaging Depth of Intravital Lung Imaging Using Perfluorocarbon-Based Liquid Ventilation With Tissue Clearing for Deep-Tissue Imaging.

A comprehensive method to analyze single-cell vibrations.

Pulmonary surfactant function and molecular architecture is disrupted in the presence of vaping additives.

Caveolin-initiated macropinocytosis is required for efficient silica nanoparticles' transcytosis across the alveolar epithelial barrier.

Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis.

Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-&#x3ba;B inflammatory signaling pathway in human skin cells.

Beta3-Tubulin is Critical for Microtubule Dynamics, Cell Cycle Regulation, and Spontaneous Release of Microvesicles in Human Malignant Melanoma Cells (A375).

Dysfunction of pulmonary surfactant mediated by phospholipid oxidation is cholesterol-dependent.

Determining the Molecular Mechanisms of Skeletal Muscle Contraction and Force Production by Combining Nano-Mechanics, Fluorescent Antibody Labeling, and High Resolution Cryo-Electron Tomography

Highly Dexterous Robotic Endoscope for Improved Access to Minimally Invasive Surgery and Diagnostics

Glow Discharger and Vitrification Robot for Cryo-EM Studies

The pathogenesis of vaping-associated lung injury: interactions between the alveolar epithelium and the immune system

Cell and Tissue Vibrations

Cell- and Tissue Vibrations

Single Chain Antibodies to Probe the Molecular Basis of Epigenetics In Living Cells.

Biophysical basis of single cell force spectroscopy

Biophysical basis of single cell force spectroscopy

Frequent collaborators

Paul Kubes

Walter Herzog

Pere Santamaria

Craig Jenne

John Conly

Mary Brindle

Ajitha Thanabalasuriar

Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-κB inflammatory signaling pathway in human skin cells.