Faculty profile

Pere Santamaria

ResearcherMicrobiology and Infectious DiseasesUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Pere Santamaria

Researcher

Microbiology and Infectious Diseases

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
28 publications in the last five years, latest in 2026.
Senior (last) author on 14 recent papers, a sign of leading a research group.
Principal investigator on 19 research grants (14 CIHR, 5 NSERC), most recently in 2022.
Supervisor on 1 trainee award (1 CIHR), most recently in 2013.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Type 1 Diabetes Autoimmune Disease T-Regulatory Type-1 Cells T-Cell Development And Function Autoimmunity Chronic Inflammation Gene Knock-In/Knock-Mice Lineage Tracing

Latest papers

First exposure to SARS-CoV-2 shapes IgG subclass switching after mRNA vaccination.
Communications medicine · 2026
Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04.
Journal of immunology (Baltimore, Md. : 1950) · 2026
Uncovering combination therapies for immune-mediated inflammatory diseases through systems biology analysis on longitudinal patient data.
Cell reports. Medicine · 2026

All 91 publications

Latest funding

Structural determinants and mechanisms underlying the Major Histocompatibility Complex Class II gene-linked resistance to autoimmune diabetes
CIHR · 2022 · Nominated PI
$1,063,350
Epigenetic and transcriptional regulation of a novel T-follicular helper (TFH)-to-T-regulatory type-1 (TR1) cell differentiation pathway
CIHR · 2022 · Nominated PI
$1,055,700
Spatio-temporal dynamics of immune and non-immune islet injury in Type 1 Diabetes
CIHR · 2022 · Principal investigator
$1,750,000

All 23 grants and awards

91 publications.

First exposure to SARS-CoV-2 shapes IgG subclass switching after mRNA vaccination.

Martin Pérez C, Ruiz-Rius S, Ramírez-Morros A, Vidal M, Jiménez A, Izquierdo L, Santamaria P, Vidal-Alaball J, Beeson JG, Molinos-Albert LM, Aguilar R, Ruiz-Comellas A, Moncunill G, Dobaño C

Communications medicine2026

DOI: 10.1038/s43856-026-01723-2 PMID: 42343025

Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04.

Amdare N, Ali R, Manganaro A, Baker JC, Antal Z, Smith C, Santamaria P, Kent SC, DiLorenzo TP

Journal of immunology (Baltimore, Md. : 1950)2026

DOI: 10.1093/jimmun/vkaf381 PMID: 41764741

Uncovering combination therapies for immune-mediated inflammatory diseases through systems biology analysis on longitudinal patient data.

Martínez-Mateu SH, Guillén Y, Angelats E, López-Lasanta MA, Madonna S, Jiménez-Gracia L, Rodriguez-Nunez I, Álvarez-Errico D, Aterido A, Tortosa R, Ruiz M, Serra P, Cañete JD, Carrascosa JM, Domènech E, Gisbert JP, Tornero J, IMID-Consortium, Siegmund B, Girolomoni G, Choy EHS, Myers RM, Heyn H, Santamaria P, Marsal S, Julià A

Cell reports. Medicine2026

DOI: 10.1016/j.xcrm.2026.103026 PMID: 42727586

Murine autoantigen-specific type 1 regulatory T cells promote oligodendrogenesis through amphiregulin-EGFR signaling.

Clarke R, Rayatpour A, Garnica J, Lozinski BM, Lee J, Mohapatra S, Yamanouchi J, Moro J, Mondal D, Morch MT, Khakpour M, Murray CJ, Volk C, Tremblay ME, Serra P, Yang Y, Yong VW, Santamaria P

Science translational medicine2026Senior author

DOI: 10.1126/scitranslmed.aef2269 PMID: 42455897

Primary SARS-CoV-2 exposure by vaccination or infection shapes immune responses to omicron variants among a Spanish cohort.

Ranzani O, Martín Pérez C, Rubio R, Ramírez-Morros A, Jimenez A, Vidal M, Canyelles M, Torres C, Barrios D, Cuamba I, Santamaria P, Serra P, Izquierdo L, Vidal-Alaball J, Molinos-Albert LM, Aguilar R, Ruiz-Comellas A, Moncunill G, Dobaño C

Nature communications2025

DOI: 10.1038/s41467-025-67577-9 PMID: 41390560

Correction: Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile.

Rubio R, Aguilar R, Bustamante M, Muñoz E, Vázquez-Santiago M, Santano R, Vidal M, Melero NR, Parras D, Serra P, Santamaria P, Carolis C, Izquierdo L, Gómez-Roig MD, Dobaño C, Moncunill G, Mazarico E

Frontiers in immunology2025

DOI: 10.3389/fimmu.2025.1672095 PMID: 41322422

Mechanistic and therapeutic advances in immune-mediated gastrointestinal disorders.

Garabatos N, Angelats E, Santamaria P

The Journal of allergy and clinical immunology2025Senior author

DOI: 10.1016/j.jaci.2025.07.024 PMID: 40783002

Contextual regulation of T follicular helper cell expansion and differentiation into T regulatory type 1 cells by multiple transcription factors.

Garnica J, Yamanouchi J, Thiessen S, Moro J, Canut E, Palou M, Mondal D, Serra P, Santamaria P

Cell reports2025Senior author

DOI: 10.1016/j.celrep.2025.116381 PMID: 41100252

Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection.

Martín Pérez C, Ramírez-Morros A, Jiménez A, Vidal M, Pradenas E, Barrios D, Canyelles M, Rubio R, Cuamba I, Izquierdo L, Santamaria P, Trinité B, Vidal-Alaball J, Molinos-Albert LM, Blanco J, Aguilar R, Ruiz-Comellas A, Moncunill G, Dobaño C

Communications medicine2025

DOI: 10.1038/s43856-025-00943-2 PMID: 40542134

Autoantigen-Specific Immunotherapies for the Prevention and Treatment of Type 1 Diabetes.

Peakman M, Santamaria P

Cold Spring Harbor perspectives in medicine2025Senior author

DOI: 10.1101/cshperspect.a041598 PMID: 39284667

Structural determinants and mechanisms underlying the Major Histocompatibility Complex Class II gene-linked resistance to autoimmune diabetes

Nominated PICIHR2022Project Grant

Principal investigators: Santamaria, Pere

Keywords: Autoimmunity; Autoreactive T-Cells; Genetic Resistance; Major Histocompatibility Complex Class Ii Genes; Mhc Class Ii Promiscuity; Pmhc:Tcr Crystal Structures; Thymic T-Regulatory Cell Deviation; Type 1 Diabetes

$1,063,350

Epigenetic and transcriptional regulation of a novel T-follicular helper (TFH)-to-T-regulatory type-1 (TR1) cell differentiation pathway

Nominated PICIHR2022Project Grant

Principal investigators: Santamaria, Pere

Keywords: Autoimmune Disease; Epigenetic Changes; Immunization; Immunoregulation; Nanomedicine; T-Follicular Helper Cells; T-Regulatory Type-1 Cells; Transcriptional Regulation

$1,055,700

Spatio-temporal dynamics of immune and non-immune islet injury in Type 1 Diabetes

Principal investigatorCIHR2022Team Grant: CIHR-JDRF Type 1 Diabetes and Precision Medicine

Principal investigators: Thompson, Peter; Greenberg, Dana; Gaisano, Herbert Y; Rutter, Guy A; Santamaria, Pere

Keywords: Beta Cell Heterogeneity; Human Pancreas Slices; Nonobese Diabetic (Nod) Mouse Model; Pancreatic Islet Beta Cells; Type 1 Diabetes

$1,750,000

Immunometabolism in diabetes: harnessing metabolic crosstalk between islets and immune cells for therapy

Principal investigatorCIHR2021Team Grant: Diabetes Mechanisms and Translational Solutions - General Pool

Principal investigators: Verchere, Bruce C; Hosak, Ramya; Klein Geltink, Ramon; Levings, Megan K; Santamaria, Pere; Tsai, Sue Y

Keywords: Immunometabolism; Immunomodulation; Insulin; Islet; Macrophages; Metabolomics; Sex Differences; T Cells; T Regulatory Cells; Type 1 Diabetes

$2,000,000

Immunometabolism in diabetes: harnessing metabolic crosstalk between islets and immune cells for therapy

Principal investigatorCIHR2020Team Grant: DM/TS - CIHR-JDRF - ß-cell and Pancreatic Islet Physiology - LOI

Principal investigators: Verchere, Bruce C; Klein Geltink, Ramon; Levings, Megan K; Santamaria, Pere; Tsai, Sue Y

Keywords: Immunometabolism; Immunomodulation; Insulin; Islet; Macrophages; Metabolomics; Sex Differences; T Cells; T Regulatory Cells; Type 1 Diabetes

$10,000

Microbiome Regulation of Beta-Cell Autoimmunity and Type 1 Diabetes

Co-investigatorCIHR2019Team Grant: Canadian Microbiome Initiative 2: Research Teams - CIHR-JDRF Pool

Principal investigators: Danska, Jayne S; Allen-Vercoe, Emma; McCoy, Kathy; Sycuro, Laura K

Keywords: Animal Models; High-Throughput Dna Sequencing; Human Birth Cohort Study; Immunology; Microbiome; Type 1 Diabetes

$1,000,000

Microbiome regulation of beta cell autoimmunity and diabetes

Principal investigatorCIHR2018Team Gr: Canadian Microbiome Initiative 2: Research Teams - LOI - CIHR-JDRF Pool

Principal investigators: Danska, Jayne S; Allen-Vercoe, Emma; McCoy, Kathy; Santamaria, Pere; Sycuro, Laura K

Keywords: Flow Cytometry; Human Prospective Studies; Immunology; Metabolomics; Microbiome; Mouse Models; Multi/Variate Statistical Analysis; Type 1 Diabetes

$25,000

Mechanisms underlying the formation of autoantigen-specific regulatory networks in vivo

Nominated PICIHR2016Project Grant

Principal investigators: Santamaria, Pere

Keywords: Autoimmune Disease; B-Regulatory Cells; Chronic Inflammation; Gene Knock-In/Knock-Mice; Lineage Tracing; Nanomedicines; Peptide-Mhc; T-Cell Development And Function; T-Regulatory Type-1 Cells; Type 1 Diabetes

$1,074,124

Advancing antigen-specific nanomedicines for the treatment of autoimmune disease: mechanistic and translational studies.

Nominated PICIHR2015Foundation Grant

Principal investigators: Santamaria, Pere

Keywords: Autoimmune Disease; Chronic Inflammation; Gene Knock-In/Knock-Mice; Human Autoimmune Disease; Immunogenetics; Lineage Tracing; Nanomedicines; Peptide-Mhc; T-Cell Development And Function; T-Regulatory Type-1 Cells

$3,424,092

Advancing an antigen-specific nanomedicine for the treatment of central nervous system autoimmunity

Nominated PICIHR2014Team Grant: Neuroinflammation

Principal investigators: Santamaria, Pere

Keywords: Cns Autoimmunity; Disease-Specific Immunoregulation; Humanized Mice; Pmhc-Based Nanomedicines; Relapsing-Remitting Ms; T-Regulatory Type 1 Cd4+ T-Cells; Therapeutics

$225,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Pere Santamaria

Research

Latest papers

Latest funding

First exposure to SARS-CoV-2 shapes IgG subclass switching after mRNA vaccination.

Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04.

Uncovering combination therapies for immune-mediated inflammatory diseases through systems biology analysis on longitudinal patient data.

Murine autoantigen-specific type 1 regulatory T cells promote oligodendrogenesis through amphiregulin-EGFR signaling.

Primary SARS-CoV-2 exposure by vaccination or infection shapes immune responses to omicron variants among a Spanish cohort.

Correction: Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile.

Mechanistic and therapeutic advances in immune-mediated gastrointestinal disorders.

Contextual regulation of T follicular helper cell expansion and differentiation into T regulatory type 1 cells by multiple transcription factors.

Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection.

Autoantigen-Specific Immunotherapies for the Prevention and Treatment of Type 1 Diabetes.

Structural determinants and mechanisms underlying the Major Histocompatibility Complex Class II gene-linked resistance to autoimmune diabetes

Epigenetic and transcriptional regulation of a novel T-follicular helper (TFH)-to-T-regulatory type-1 (TR1) cell differentiation pathway

Spatio-temporal dynamics of immune and non-immune islet injury in Type 1 Diabetes

Immunometabolism in diabetes: harnessing metabolic crosstalk between islets and immune cells for therapy

Immunometabolism in diabetes: harnessing metabolic crosstalk between islets and immune cells for therapy

Microbiome Regulation of Beta-Cell Autoimmunity and Type 1 Diabetes

Microbiome regulation of beta cell autoimmunity and diabetes

Mechanisms underlying the formation of autoantigen-specific regulatory networks in vivo

Advancing antigen-specific nanomedicines for the treatment of autoimmune disease: mechanistic and translational studies.

Advancing an antigen-specific nanomedicine for the treatment of central nervous system autoimmunity

Frequent collaborators

Sue Tsai

Paul Kubes

Carol Huang

Yan Shi

Anmar Khadra

Mark Swain

Andrew Mason

Amanda Ricciuto

Gideon Hirschfield

Matthias Amrein

Sonya MacParland