Faculty profile

Paul Kubes

ResearcherPhysiology and PharmacologyUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Paul Kubes

Researcher

Physiology and Pharmacology

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
42 publications in the last five years, latest in 2026.
Senior (last) author on 25 recent papers, a sign of leading a research group.
Principal investigator on 26 research grants (23 CIHR, 3 NSERC), most recently in 2023.
Supervised 10 trainees who won CIHR awards, most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

234

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Imaging Inflammation Neutrophils Cancer In Vivo Macrophages Microbiome Microscopy

Latest papers

Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.
The Journal of clinical investigation · 2026
Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice.
Journal of immunology (Baltimore, Md. : 1950) · 2026
Imaging Staphylococcus aureus biofilms in vivo reveals neutrophil exclusion by PNAG exopolysaccharide.
mBio · 2026 · senior author

All 234 publications

Latest funding

Understanding the role of GATA6+ macrophages in health and disease
CIHR · 2023 · Nominated PI
$895,050
Understanding the role of GATA6+ macrophages in health and disease.
CIHR · 2022 · Nominated PI
$100,000
Studying classical inflammatory and repair neutrophils in cardiovascular system using novel in vivo imaging approaches
CIHR · 2022 · Nominated PI
$841,500

All 37 grants and awards

From the 150 most recent of 234 publications.

Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.

Salm L, Zwicky SN, Spari D, Yarahmadov T, Siwicki M, Castanheira FVES, Zbinden J, Stroka D, Zindel J, Dufour A, Kubes P, Beldi G

The Journal of clinical investigation2026

DOI: 10.1172/jci198632 PMID: 41871299

Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice.

Mafra K, de Oliveira MG, Nakagaki BNL, Porto Pedrosa MLM, Lanser TB, da Silva P, Antunes MM, da Silva Júnior WF, Mattos MS, Lopes ME, da Rocha Fernandes G, Cunha TM, Pinto de Paula CM, David BA, Rastogi T, Yang Z, Babar MU, Konnikava L, Caetano AM, Vale AM, Kubes P, Libreros S, Rezende RM, Menezes GB

Journal of immunology (Baltimore, Md. : 1950)2026

DOI: 10.1093/jimmun/vkaf264 PMID: 41138221

Imaging Staphylococcus aureus biofilms in vivo reveals neutrophil exclusion by PNAG exopolysaccharide.

Kratofil RM, Sejuty RT, Randall TE, Hommes JW, Chisholm J, Willson M, Shim R, Raju D, Vargas MA, Howell PL, Pier GB, Morck DW, Harrison JJ, Kubes P

mBio2026Senior author

DOI: 10.1128/mbio.00522-26 PMID: 42535832

Neutrophil-hybrid CAR-macrophages bring double trouble to tumors.

Siwicki M, Kubes P

Nature immunology2026Senior author

DOI: 10.1038/s41590-026-02650-z PMID: 42711526

Targeting virulence factors Psl and PcrV restores host defense in bronchiectasis and cystic fibrosis models.

Qin W, Brailsford W, Cromer Berman SM, Thornton CS, DiGiandomenico A, Kubes P

The Journal of clinical investigation2026Senior author

DOI: 10.1172/jci205523 PMID: 42771482

A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.

Salm L, Lopez MA, Jenkins E, Shim R, Tejada O, Abou Mehrem B, Huang S, Etemadi Nezhad P, Derakhshani A, Lee WY, Nusse Y, Mewburn JB, Noskovicova N, Bayer J, Rashid MU, Li X, Baltaci Z, Young D, Carneiro MB, Fritzsche M, Jakubzick CV, Peters NC, Deniset JF, Zindel J, Dufour A, Yipp BG, Ditlev JA, Dustin ML, Canton J, Kubes P

The Journal of experimental medicine2026Senior author

DOI: 10.1084/jem.20260410 PMID: 42484560

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.

Araujo David B, Andreata F, Blériot C, Ginhoux F, Kubes P, Iannacone M

Nature reviews. Immunology2026

DOI: 10.1038/s41577-026-01288-0 PMID: 41951893

Intravital Imaging as a Tool to Uncover Roles of Immune Cells in Chronic Liver Diseases.

Rashid MU, Lee WY, Kubes P

JHEP reports : innovation in hepatology2026Senior author

DOI: 10.1016/j.jhepr.2026.102030 PMID: 42744247

Natural antibodies as frontline helpers in bacterial clearance.

Araujo David B, Kubes P

Journal of leukocyte biology2025Senior author

DOI: 10.1093/jleuko/qiaf028 PMID: 40372771

A historical perspective of Kupffer cells in the context of infection.

Graham CT, Gordon S, Kubes P

Cell and tissue research2025Senior author

DOI: 10.1007/s00441-024-03924-4 PMID: 39392500

Understanding the role of GATA6+ macrophages in health and disease

Nominated PICIHR2023Project Grant

Principal investigators: Kubes, Paul

Keywords: Adhesions; Cancer; Fibrosis; Imaging; In Vivo; Inflammation; Macrophages; Microfluidics; Polyinosinic Acid; Therapeutics

$895,050

Understanding the role of GATA6+ macrophages in health and disease.

Nominated PICIHR2022Project Grant

Principal investigators: Kubes, Paul

Keywords: Adhesions; Cancer; Fibrosis; Imaging; In Vivo; Inflammation; Macrophages; Microfluidics; Polyinosinic Acid; Therapeutics

$100,000

Studying classical inflammatory and repair neutrophils in cardiovascular system using novel in vivo imaging approaches

Nominated PICIHR2022Project Grant

Principal investigators: Kubes, Paul

Keywords: Bone Marrow; Cardiovascular; Heart; Imaging; In Vivo; Inflammation; Macrophages; Microscopy; Neutrophils

$841,500

A Tale of Two Resident Lung Macrophages and Their Biology In Health and Disease

Nominated PICIHR2021Project Grant

Principal investigators: Kubes, Paul

Keywords: Bacteria; Flu; Gata6 Cavity Macrophages; In Vivo; Lung; Macrophages; Microbiome; Microscopy; Migration; Pleural Space

$1,262,250

Intravital imaging of COVID-19 lungs to visualize pathogenic differences between SARS-CoV-2 variants of concern

Nominated PICIHR2021Operating Grant: Emerging COVID-19 Research Gaps and Priorities - Variants

Principal investigators: Kubes, Paul; Corcoran, Jennifer A; McDonald, Braedon A

Keywords: Brain; Endothelium; Heart; Imaging; Innate Immunity; Lungs; Neutrophils; Platelets; Sars-Cov2; Variants Of Concern

$499,829

Therapeutic Targeting a Shared Inflammation Pathway in the Lung and Kidney

Principal investigatorCIHR2021Team Grant: Preparation to Trial: Inflammation for Chronic Conditions

Principal investigators: Muruve, Daniel A; Kubes, Paul; Senger, Donna L

Keywords: Chronic Kidney Disease; Chronic Lung Disease; Critical Illness; Inflammation; Therapeutics

$750,000

Adding FLIM to Image and Analyze Metabolism Hypoxia, Fibrosis and beyond during an Immune Response

Principal investigatorNSERC2021Research Tools and Instruments

Principal investigators: Kubes, Paul

$144,293

The Biology of Liver Macrophages at Birth and Throughout Life

Nominated PICIHR2021Project Grant

Principal investigators: Kubes, Paul

Keywords: Bacteria; Fibrosis; In Vivo; Kupffer Cells; Liver; Macrophages; Microbiome; Microscopy; Recruitment; Sinusoids

$1,040,400

Imaging COVID-19 Lungs to Uncover Therapies

Nominated PICIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Kubes, Paul; Corcoran, Jennifer A; Gillrie, Mark R; Jenne, Craig N; Kelly, Margaret M; McDonald, Braedon A; Mody, Christopher H; Peters, Nathan

Keywords: Endothelium; Innate Immunity; Intravital Imaging; Lungs; Monocytes; Neutrophils; Nk Cells; Organoids; Patelets; Vasculature

$1,271,404

In vivo imaging of host-SARS-CoV-2 interaction in the lung of mice and the role of alveolar macrophages in the disease pathogenesis.

SupervisorCIHR2020CIHR Fellowship

Principal investigators: Castanheira, Fernanda V

Keywords: Alveolar Macrophages; Covid-19; In Vivo Imaging; Inflammation; Intravital; Lung; Sars-Cov-2; Secondary Infection

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Paul Kubes

Research

Latest papers

Latest funding

Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.

Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice.

Imaging Staphylococcus aureus biofilms in vivo reveals neutrophil exclusion by PNAG exopolysaccharide.

Neutrophil-hybrid CAR-macrophages bring double trouble to tumors.

Targeting virulence factors Psl and PcrV restores host defense in bronchiectasis and cystic fibrosis models.

A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.

Intravital Imaging as a Tool to Uncover Roles of Immune Cells in Chronic Liver Diseases.

Natural antibodies as frontline helpers in bacterial clearance.

A historical perspective of Kupffer cells in the context of infection.

Adding FLIM to Image and Analyze Metabolism Hypoxia, Fibrosis and beyond during an Immune Response

Frequent collaborators

Braedon McDonald

Paul Kubes

Craig Jenne

George Chaconas

Pere Santamaria

John Conly

Sonya MacParland

Kathy McCoy

Antoine Dufour

Ajitha Thanabalasuriar

Margaret Kelly

Kelly McNagny

Kunyan Zhang

Matthias Amrein

Justin Deniset

Bas Surewaard

Jérôme Fortin

Henry Nguyen

Andrew Mason

Ian Ball

Sheila Singh

Parvez Vora

Christophe Altier

Michael Glogauer

Robert Rottapel

Braden Manns

Christopher Power

Claudia Dos Santos