Faculty profile
Christian Kastrup
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Research
Latest papers
Engineering tough blood clots for rapid haemostasis and enhanced regeneration.
Nature · 2026
Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma.
Gastroenterology · 2026
Encapsulation of Fibrinogen With Calcium Carbonate for Hemorrhage Control.
Military medicine · 2025
Latest funding
- $6,000
Applying the CRISPR-PASTE Technology to Alleviate Thrombosis
CIHR · 2024 · Supervisor
- $105,000
Increasing the natural coagulability of transfusable platelets using mRNA-lipid nanoparticles
CIHR · 2022 · Supervisor
- $105,000
Developing RNA gene therapies to modulate circulating PAI-1 to alleviate thrombosis
CIHR · 2022 · Supervisor
8 publications.
Engineering tough blood clots for rapid haemostasis and enhanced regeneration.
Jiang S, Bao G, Yang Z, Wu J, Yang X, Kim JEJ, Jiang R, Zhan Y, Nottegar A, Liu Y, Gao ZH, Beckett A, Nijnik A, Long R, Kastrup C, Li J
Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma.
Chowdhury NN, Mitchell DK, Kangro K, Eldridge K, Abrahams S, Ferraresso F, Juang LJ, Gampala S, Brewster K, Revenko A, Kastrup C, Territo PR, Clapp DW, Wang J, Belgodere JA, Saeed O, Choi SR, Han B, Wolberg AS, Cao S, Zhang C, Flick MJ, Fishel ML
Encapsulation of Fibrinogen With Calcium Carbonate for Hemorrhage Control.
Peng HT, Bonnici T, Kastrup C, Beckett A
Emulsion-Based Encapsulation of Fibrinogen with Calcium Carbonate for Hemorrhage Control.
Peng HT, Bonnici T, Chen Y, Kastrup C, Beckett A
Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.
Bao G, Gao Q, Cau M, Ali-Mohamad N, Strong M, Jiang S, Yang Z, Valiei A, Ma Z, Amabili M, Gao ZH, Mongeau L, Kastrup C, Li J
Hemostatic powders for gastrointestinal bleeding: a review of old, new, and emerging agents in a rapidly advancing field.
Jiang SX, Chahal D, Ali-Mohamad N, Kastrup C, Donnellan F
Severe upper gastrointestinal bleeding is halted by endoscopically delivered self-propelling thrombin powder: A porcine pilot study.
Ali-Mohamad N, Cau M, Baylis J, Zenova V, Semple H, Beckett A, McFadden A, Donnellan F, Kastrup C
The evolution of factor XI and the kallikrein-kinin system.
Ponczek MB, Shamanaev A, LaPlace A, Dickeson SK, Srivastava P, Sun MF, Gruber A, Kastrup C, Emsley J, Gailani D
Applying the CRISPR-PASTE Technology to Alleviate Thrombosis
Principal investigators: Ferraresso, Francesca
Keywords: Anticoagulant Therapy; Cardiovascular Event; Crispr-Paste; Fibrinolysis; Hemostatic Proteins; Thrombosis; Tissue Plasminogen Activator
Increasing the natural coagulability of transfusable platelets using mRNA-lipid nanoparticles
Principal investigators: Strong, Colton
Keywords: Cell Therapy; Hemostasis And Thrombosis; Lipid Nanoparticles; Nanomedicine; Nucleic Acid Delivery; Platelet Activation; Platelet Engineering; Platelet Transfusion; Transfection; Trauma
Developing RNA gene therapies to modulate circulating PAI-1 to alleviate thrombosis
Principal investigators: Ferraresso, Francesca
Keywords: Age-Associated Diseases; Crispr Gene Editing; Lipid Nanoparticles; Liver; Plasminogen Activator Inhibitor 1; Rna Gene Therapy; Thrombosis
Bioengineering Tough Blood Clots for Hemorrhage Control
Principal investigators: Li, Jianyu
Keywords: Biomaterials; Biomechanics; Bleeding Disorders; Cellular Engineering; Click Chemistry; Hemorrage; Hemostasis
Minimally-invasive device and bioabsorbable hemostatic powder for managing non-compressible torso hemorrhage
Principal investigators: Kastrup, Christian J
Keywords: Abdominal Hemorrhage; Care-Under-Fire; Fibrinolysis; Hemostasis; Hemostatics; Incompressible Hemorrhage; Pre-Hospital; Tranexamic Acid; Trauma-Induced Coagulopathy; Wound Management
Liver as a bioreactor for robust production of SARS-CoV-2 neutralizing antibodies
Principal investigators: Cullis, Pieter R
Keywords: Antibody Expression; Lipid Nanoparticle Therapy; Liver As A Bioreactor; Self-Passive Immunization
Using a novel anti-FXIII agent as an effective and safe antithrombotic for ECMO
Principal investigators: Strilchuk, Amy W
Keywords: Animal Models; Biochemistry; Gene Therapy; Hematology; Nanomedicine
High throughput flow cytometer for the Michael Smith Laboratories
Principal investigators: Mayor, Thibault
Equipment to quantify levels of the pleiotropic, blood-based enzyme, thrombin
Principal investigators: Conway, Edward
Enhancing Transfusable Platelets Using mRNA Therapy to Produce Exogenous Proteins
Principal investigators: Leung, Jerry
Keywords: Cancer Targeting; Cell Therapy; Flow Cytometry; Hemorrhage Control; Lipid Nanoparticles; Nucleic Acid Delivery; Platelet Disorders; Platelet Engineering; Platelet Transfusion
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Christian Kastrup and Jianyu Li: 2 shared papers
- Anastasia Nijnik and Christian Kastrup: 1 shared paper
- Anastasia Nijnik and Jianyu Li: 1 shared paper
- Michael Smith Laboratories
- Mechanical Engineering
- Physiology
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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