Faculty profile

Anastasia Nijnik

ResearcherPhysiologyMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Anastasia Nijnik

Researcher

Physiology

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
11 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (9 CIHR, 3 NSERC), most recently in 2024.
Supervisor on 1 trainee award (1 CIHR), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Hematopoiesis Transcriptional Regulation Hematopoietic Stem And Progenitor Cells Epigenetic Regulation Transgenic Mouse Models Inherited Bone Marrow Failure Syndrome Ribosomopathy Transgenic/Knockout Mouse Models

Latest papers

Emergency myelopoiesis in murine arthritis results in cell-intrinsic changes in dendritic cell development and function.
iScience · 2026 · senior author
Engineering tough blood clots for rapid haemostasis and enhanced regeneration.
Nature · 2026
Low Dose Methotrexate Has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells.
Clinical and translational science · 2025

All 31 publications

Latest funding

MYSM1 Deficiency as a Novel Ribosomopathy Bone Marrow Failure: dissecting the transcriptional and cellular mechanisms using murine models.
CIHR · 2024 · Nominated PI
$975,376
Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.
CIHR · 2024 · Co-investigator
$1,040,400
Chromatin-binding deubiquitinase MYSM1 as a putative drug target for cMYC-driven B cell lymphoma
CIHR · 2023 · Nominated PI
$761,176

All 15 grants and awards

31 publications.

Emergency myelopoiesis in murine arthritis results in cell-intrinsic changes in dendritic cell development and function.

Tung LT, Jiang RR, Pozzebon B, Mancini M, Droin L, Yousefi M, Kim JEJ, Mousa M, Liang Y, Krawczyk CM, Colmegna I, Malo D, Langlais D, Vidal SM, Nijnik A

iScience2026Senior author

DOI: 10.1016/j.isci.2026.116644 PMID: 42491772

Engineering tough blood clots for rapid haemostasis and enhanced regeneration.

Jiang S, Bao G, Yang Z, Wu J, Yang X, Kim JEJ, Jiang R, Zhan Y, Nottegar A, Liu Y, Gao ZH, Beckett A, Nijnik A, Long R, Kastrup C, Li J

Nature2026

DOI: 10.1038/s41586-026-10412-y PMID: 42056507

Low Dose Methotrexate Has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells.

Lora M, Ménard HA, Nijnik A, Langlais D, Hudson M, Colmegna I

Clinical and translational science2025

DOI: 10.1111/cts.70233 PMID: 40289289

Hematopoietic Stem Cell Fates and the Cellular Hierarchy of Mammalian Hematopoiesis: from Transplantation Models to New Insights from in Situ Analyses.

Shaban D, Najm N, Droin L, Nijnik A

Stem cell reviews and reports2025Senior author

DOI: 10.1007/s12015-024-10782-8 PMID: 39222178

Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation.

Mousa M, Liang Y, Tung LT, Wang H, Krawczyk C, Langlais D, Nijnik A

Immunology2024Senior author

DOI: 10.1111/imm.13758 PMID: 38316548

B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1.

Liang Y, Wang H, Seija N, Lin YH, Tung LT, Di Noia JM, Langlais D, Nijnik A

Frontiers in immunology2024Senior author

DOI: 10.3389/fimmu.2024.1353138 PMID: 38529289

Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis.

Kim JEJ, Tung LT, Jiang RR, Yousefi M, Liang Y, Malo D, Vidal SM, Nijnik A

Immunology2023Senior author

DOI: 10.1111/imm.13691 PMID: 37688495

Histone H2A deubiquitinases in the transcriptional programs of development and hematopoiesis: a consolidated analysis.

Wang H, Langlais D, Nijnik A

The international journal of biochemistry & cell biology2023Senior author

DOI: 10.1016/j.biocel.2023.106384 PMID: 36738766

Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.

Liang Y, Bhatt G, Tung LT, Wang H, Kim JE, Mousa M, Plackoska V, Illes K, Georges AA, Gros P, Henneman L, Huijbers IJ, Nagar B, Nijnik A

Scientific reports2023Senior author

DOI: 10.1038/s41598-023-27486-7 PMID: 36611064

Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression.

Plackoska V, Shaban D, Nijnik A

Frontiers in immunology2022Senior author

DOI: 10.3389/fimmu.2022.1041010 PMID: 36561751

MYSM1 Deficiency as a Novel Ribosomopathy Bone Marrow Failure: dissecting the transcriptional and cellular mechanisms using murine models.

Nominated PICIHR2024Project Grant

Principal investigators: Nijnik, Anastasia; Craig, Morgan; Langlais, David

Keywords: Epigenetic Regulation; Hematopoiesis; Hematopoietic Stem And Progenitor Cells; Inherited Bone Marrow Failure Syndrome; Rare Disease; Ribosomopathy; Transcriptional Regulation; Transgenic/Knockout Mouse Models

$975,376

Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.

Co-investigatorCIHR2024Project Grant

Principal investigators: Colmegna, Ines; Langlais, David; Martin, James G

Keywords: Anti-Fibrosis; Cellular Therapy; Fibrosis; Fibrosis Resolution; Lung Fibrosis; Multipotent Mesenchymal Stromal Cells; Scleroderma; Skin Fibrosis; Systemic Bleomycin Minipump Model

$1,040,400

Chromatin-binding deubiquitinase MYSM1 as a putative drug target for cMYC-driven B cell lymphoma

Nominated PICIHR2023Project Grant

Principal investigators: Nijnik, Anastasia; Nagar, Bhushan

Keywords: B Cell Lymphoma; Carcinogenesis; Deubiquitinase; Epigenetic Regulation; Gene Expression; High-Throughput Screening; Myc; Protein Structure; Transcriptional Regulation; X-Ray Crystallography

$761,176

P2X7 and p53 in the Regulation of Hematopoietic Response to Genotoxic Stress

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Nijnik, Anastasia

Keywords: DNA damage response and repair; gene expression; genotoxic stress; hematopoietic stem and progenitor cells; hematopoietic system; P2X7; p53; transcriptional regulation; transgenic mouse models; whole-body irradiation

$144,000

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

Principal investigatorNSERC2023Research Tools and Instruments

Principal investigators: Nijnik, Anastasia

$150,000

Deubiquitinase MYSM1 as an essential epigenetic regulator of hematopoiesis

Nominated PICIHR2022Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Nijnik, Anastasia; Langlais, David

Keywords: Atac-Seq; Chip-Seq; Epigenetic Regulation; Erythropoiesis; Hematopoiesis; Hematopoietic Stem And Progenitor Cells; Inherited Bone Marrow Failure Syndrome; Ribosomopathy; Transcriptional Regulation; Transgenic/Knockout Mouse Models

$100,000

Bioengineering Tough Blood Clots for Hemorrhage Control

Co-investigatorCIHR2021Project Grant

Principal investigators: Li, Jianyu

Keywords: Biomaterials; Biomechanics; Bleeding Disorders; Cellular Engineering; Click Chemistry; Hemorrage; Hemostasis

$677,025

P2X7 - a Novel Regulator of Hematopoietic Stem Cell and Resistance to Genotoxic Stress

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Tung, Lin Tze

Keywords: Bone Marrow; Cancer; Chemotherapy; Drug Target Study; Genotoxic Stress; Hematopoiesis; Hematopoietic Stem Cells; P2x7; P53 Tumor Suppressor; Radiotherapy

$105,000

Hematopoietic Stem and Progenitor Cells as Mediators of Trained Immunity in Rheumatoid Arthritis

Nominated PICIHR2020Project Grant

Principal investigators: Nijnik, Anastasia; Colmegna, Ines; Langlais, David

Keywords: Epigenetics; Hematopoietic Stem And Progenitor Cells; Inflammation; Innate Immunity; Rheumatoid Arthritis; Transcriptional Regulation

$998,936

Molecular Analysis of the Diversity of Lymphoid Cell Types and Functions at Single-Cell Resolution: ProteinSimple Single-Cell Western System.

Principal investigatorNSERC2019Research Tools and Instruments

Principal investigators: Nijnik, Anastasia

$133,253

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Anastasia Nijnik

Research

Latest papers

Latest funding

Emergency myelopoiesis in murine arthritis results in cell-intrinsic changes in dendritic cell development and function.

Engineering tough blood clots for rapid haemostasis and enhanced regeneration.

Low Dose Methotrexate Has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells.

Hematopoietic Stem Cell Fates and the Cellular Hierarchy of Mammalian Hematopoiesis: from Transplantation Models to New Insights from in Situ Analyses.

Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation.

B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1.

Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis.

Histone H2A deubiquitinases in the transcriptional programs of development and hematopoiesis: a consolidated analysis.

Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.

Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression.

MYSM1 Deficiency as a Novel Ribosomopathy Bone Marrow Failure: dissecting the transcriptional and cellular mechanisms using murine models.

Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.

Chromatin-binding deubiquitinase MYSM1 as a putative drug target for cMYC-driven B cell lymphoma

P2X7 and p53 in the Regulation of Hematopoietic Response to Genotoxic Stress

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

Deubiquitinase MYSM1 as an essential epigenetic regulator of hematopoiesis

Bioengineering Tough Blood Clots for Hemorrhage Control

P2X7 - a Novel Regulator of Hematopoietic Stem Cell and Resistance to Genotoxic Stress

Hematopoietic Stem and Progenitor Cells as Mediators of Trained Immunity in Rheumatoid Arthritis

Molecular Analysis of the Diversity of Lymphoid Cell Types and Functions at Single-Cell Resolution: ProteinSimple Single-Cell Western System.

Frequent collaborators

David Langlais

Danielle Malo

Jerry Pelletier

Philippe Gros

Bruce Mazer

Maziar Divangahi

Eva Kaufmann

Bhushan Nagar

Luda Diatchenko

Arkady Khoutorsky

Jianyu Li

Jean-Pierre Routy

Ines Colmegna

Sidong Huang

Christian Kastrup

Jean-Pierre Routy

Marie Hudson

Ciriaco Piccirillo