Christopher Loewen

Research

Membrane Contact Sites Budding Yeast Endoplasmic Reticulum Lipid Traffic Metabolism Microscopy Phosphatidylserine Trafficking

Latest papers

Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast.
Disease models & mechanisms · 2020 · senior author
Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae.
Genetics · 2017
Global reorganization of budding yeast chromosome conformation in different physiological conditions.
The Journal of cell biology · 2016

All 4 publications

Latest funding

Characterizing new functions for tethering proteins at membrane contact sites in budding yeast
CIHR · 2024 · Nominated PI
$914,175
Systematic characterization of membrane contact sites in budding yeast
CIHR · 2022 · Nominated PI
$100,000
Super Resolution Core Facility Upgrade
NSERC · 2018 · Co-investigator
$147,382

All 12 grants and awards

4 publications.

01

Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast.

Young BP, Post KL, Chao JT, Meili F, Haas K, Loewen C

Disease models & mechanisms2020Senior author

DOI: 10.1242/dmm.044560 PMID: 32471850

02

Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae.

Lawrence MBD, Coutin N, Choi JK, Martin BJE, Irwin NAT, Young B, Loewen C, Howe LJ

Genetics2017

DOI: 10.1534/genetics.117.1132 PMID: 28739661

03

Global reorganization of budding yeast chromosome conformation in different physiological conditions.

Dultz E, Tjong H, Weider E, Herzog M, Young B, Brune C, Müllner D, Loewen C, Alber F, Weis K

The Journal of cell biology2016

DOI: 10.1083/jcb.201507069 PMID: 26811423

04

A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition.

Ho KL, Ma L, Cheung S, Manhas S, Fang N, Wang K, Young B, Loewen C, Mayor T, Measday V

PLoS genetics2015

DOI: 10.1371/journal.pgen.1005109 PMID: 25822502

Characterizing new functions for tethering proteins at membrane contact sites in budding yeast

Nominated PICIHR2024Project Grant

Principal investigators: Loewen, Christopher

Keywords: Budding Yeast; Endoplasmic Reticulum; Lipid Traffic; Membrane Contact Sites; Metabolism; Microscopy; Phosphatidylserine; Trafficking

$914,175

Systematic characterization of membrane contact sites in budding yeast

Nominated PICIHR2022Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Loewen, Christopher

Keywords: Budding Yeast; Endoplasmic Reticulum; Golgi; Lipid Traffic; Membrane Contact Sites; Metabolism; Microscopy; Ph; Phosphatidylserine; Trafficking

$100,000

Super Resolution Core Facility Upgrade

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Nabi, Ivan

$147,382

Replacement of Life Sciences Institute Biomolecular Imager

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Jan, Eric

$149,677

Generation of Yeast Produced Multifunctional Antibody-Based Therapeutics Against Salmonella Gastroenteritis

Principal investigatorNSERC2017Engage Grants Program

Principal investigators: Loewen, Christopher

$25,000

Lipid signalling in yeast

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Loewen, Christopher

$457,200

Targeting novel acid stress resistance mechanisms in cancer cell metabolism

Nominated PICIHR2016Project Grant

Principal investigators: Loewen, Christopher

Keywords: Ap-3 Adapter Complex; Breast Cancer; Cancer Cell Metabolism; Glycolytic Phenotype; Intracellular Acid Stress; Lysosomes; Mitochondria; Oxidative Phosphorylation; P Bodies; Pan Deadenylase Complex

$765,000

Endoplasmic reticulum polarization: roles in spindle positioning and lipid signaling in the establishment of cell polarity in yeast

Nominated PICIHR2013Operating Grant

Principal investigators: Loewen, Christopher

Keywords: Cdc42; Cell Polarity; Dynein/Dynactin; Endoplasmic Reticulum Polarization; Lipid Signaling; Membrane Contact Sites; Mrna Targeting; Saccharomyces Cerevisiae; Septins; Spindle Positioning

$736,392

Lipid Signaling in Yeast

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Loewen, Christopher

$200,000

Endoplasmic reticulum membrane contact sites: role in ER polarization, lipid metabolism and protein trafficking.

Nominated PICIHR2008Operating Grant

Principal investigators: Loewen, Christopher

Keywords: Amyotrophic Lateral Sclerosis (Als); Endoplasmic Reticulum; Lipid Metabolism; Lipid Transfer Protein; Membrane Contact Sites; Nonvesicular Traffic

$642,840

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Physiological Sciences
Biochemistry and Molecular Biology
Food Science

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Kurt Haas

Cellular and Physiological Sciences

1 shared papers, latest 2020

Thibault Mayor

Biochemistry and Molecular Biology

1 shared papers, latest 2015

Vivien Measday

Food Science

1 shared papers, latest 2015

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Membrane Contact Sites Dear Professor Loewen, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast." (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Characterizing new functions for tethering proteins at membrane contact sites in budding yeast" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]