Thibault Mayor, University of British Columbia

Research

Ubiquitin Chaperone Protein Folding Proteasome Proteomics Protein Homeostasis Cell Biology Protein Quality Control

Latest papers

Peptide barcoding: an alternative to the phenotype-genotype problem.
New biotechnology · 2026
A direct role for a mitochondrial targeting sequence in signalling stress.
Nature · 2026
Mining yeast diversity unveils novel targets for improved heterologous laccase production in Saccharomyces cerevisiae.
Microbial cell factories · 2025 · senior author

All 46 publications

Latest funding

Molecular Principles Governing Degron Recognition in Misfolded Cytosolic Proteins with Pathological Missense Mutations
CIHR · 2026 · Nominated PI
$1,143,676
Elucidation of the client repertoires and functions of the two related DNAJB6 and B8 co-chaperones
CIHR · 2023 · Nominated PI
$1,005,976
Investigation of Pathways that Regulate the Expression of Recombinant Proteins in Yeast
NSERC · 2022 · Principal investigator
$201,000

All 16 grants and awards

46 publications.

01

Peptide barcoding: an alternative to the phenotype-genotype problem.

Hong O, Mayor T, Joshi J

New biotechnology2026

DOI: 10.1016/j.nbt.2026.08.007 PMID: 42633869

02

A direct role for a mitochondrial targeting sequence in signalling stress.

Yuan Z, Balzarini M, Volpe M, Goldstein M, Peng TS, Hui E, Fang NN, Albihlal WS, Hajimohammadi M, Wei K, Yip CK, van Werven FJ, Mayor T, Weidberg H

Nature2026

DOI: 10.1038/s41586-025-09834-x PMID: 41372412

03

Mining yeast diversity unveils novel targets for improved heterologous laccase production in Saccharomyces cerevisiae.

Wong RWK, Foo M, Lay JRS, Wai TLT, Moore J, Dutreux F, Molzahn C, Nislow C, Measday V, Schacherer J, Mayor T

Microbial cell factories2025Senior author

DOI: 10.1186/s12934-025-02677-1 PMID: 40059166

04

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations.

Baker HA, Bernardini JP, Csizmók V, Madero A, Kamat S, Eng H, Lacoste J, Yeung FA, Comyn S, Hui E, Calabrese G, Raught B, Taipale M, Mayor T

Journal of cell science2025Senior author

DOI: 10.1242/jcs.262019 PMID: 39618332

05

Lost in translation: Threonine dictates aggregation of CAT tails.

Kamat S, Mayor T

Molecular cell2024Senior author

DOI: 10.1016/j.molcel.2024.10.043 PMID: 39577399

06

Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae.

Strawn G, Wong RWK, Young BP, Davey M, Nislow C, Conibear E, Loewen CJR, Mayor T

Microbial cell factories2024Senior author

DOI: 10.1186/s12934-024-02298-0 PMID: 38287338

07

Shift of the insoluble content of the proteome in the aging mouse brain.

Molzahn C, Kuechler ER, Zemlyankina I, Nierves L, Ali T, Cole G, Wang J, Albu RF, Zhu M, Cashman NR, Gilch S, Karsan A, Lange PF, Gsponer J, Mayor T

Proceedings of the National Academy of Sciences of the United States of America2023Senior author

DOI: 10.1073/pnas.2310057120 PMID: 37906643

08

Identification of newly translated thermo-sensitive proteins using pulse SILAC mass spectrometry and the GAL promoter system.

Zhu M, Calabrese G, Wong RWK, Mayor T

STAR protocols2023Senior author

DOI: 10.1016/j.xpro.2023.102059 PMID: 36853680

09

Comparison of Biomolecular Condensate Localization and Protein Phase Separation Predictors.

Kuechler ER, Huang A, Bui JM, Mayor T, Gsponer J

Biomolecules2023

DOI: 10.3390/biom13030527 PMID: 36979462

10

Pulse labeling reveals the tail end of protein folding by proteome profiling.

Zhu M, Kuechler ER, Wong RWK, Calabrese G, Sitarik IM, Rana V, Stoynov N, O'Brien EP, Gsponer J, Mayor T

Cell reports2022Senior author

DOI: 10.1016/j.celrep.2022.111096 PMID: 35858568

Molecular Principles Governing Degron Recognition in Misfolded Cytosolic Proteins with Pathological Missense Mutations

Nominated PICIHR2026Project Grant

Principal investigators: Mayor, Thibault

Keywords: Bioid Proximity Labeling; Chaperone; Proteasome; Protein Folding; Proteolysis; Proteomics; Proteostasis; Ubiquitin

$1,143,676

Elucidation of the client repertoires and functions of the two related DNAJB6 and B8 co-chaperones

Nominated PICIHR2023Project Grant

Principal investigators: Mayor, Thibault

Keywords: Bioid; Chaperone; Neurodegeneration; Protein Aggregation; Protein Folding; Protein Homeostasis; Proteomics; Silac

$1,005,976

Investigation of Pathways that Regulate the Expression of Recombinant Proteins in Yeast

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Mayor, Thibault

$201,000

Identifying key E3 ubiquitin ligases that target disease-associated mutant cytosolic proteins for degradation

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Baker, Heather A

Keywords: Chaperones; Missense Mutations; Protein Degradation; Protein Misfolding; Protein Quality Control; Rare Genetic Diseases; Ubiquitin; Ubiquitin Ligases; Ubiquitin-Proteasome System

$105,000

High throughput flow cytometer for the Michael Smith Laboratories

Principal investigatorNSERC2020Research Tools and Instruments

Principal investigators: Mayor, Thibault

$150,000

Examining the Ubiquitin Machinery in Genetic Diseases of Protein Misfolding

SupervisorCIHR2019CIHR Fellowship

Principal investigators: Bernardini, Jonathan

Keywords: Genetic Disease; Misfolded Proteins; Proteostasis; Ubiquitin

$135,000

Proteostasis Researchers in Canada, Eh (PRinCE) Inaugural Meeting

Co-investigatorCIHR2018Planning and Dissemination Grant - Institute Community Support

Principal investigators: Young, Jason C

Keywords: Cellular Stress; Human Genetics; Neurodegeneration; Protein Aggregation; Protein Degradation; Protein Folding; Protein Trafficking; Stress Response

$10,000

Characterization of quality control pathways that target cytosolic misfolded proteins with missense mutations for proteasome degradation

Nominated PICIHR2018Project Grant

Principal investigators: Mayor, Thibault

Keywords: Cell Biology; Chaperone; E3 Ligase; Genetic Disease; Missense Mutation; Proteasome; Protein Folding; Protein Quality Control; Ubiquitin

$730,576

Analysis of the proteostasis network and the thermostability of the proteome

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Mayor, Thibault

$324,000

Characterization of the proteostasis decline upon aging

Nominated PICIHR2016Project Grant

Principal investigators: Mayor, Thibault

Keywords: Aggregation; Aging; Chaperone; Heat Shock Proteins (Hsps); Mass Spectrometry; Oxidation; Protein Folding; Protein Homeostasis; Proteomics; Ubiquitin

$668,940

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry and Molecular Biology
Food Science
Genome Sciences Centre
Research Institute
Cellular and Physiological Sciences
Cell Biology
Anesthesiology, Pharmacology and Therapeutics
Other

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Vivien Measday

Food Science

3 shared papers, latest 2025

Christopher Loewen

Cellular and Physiological Sciences

1 shared papers, latest 2015

Michel Roberge

Biochemistry and Molecular Biology

1 shared papers, latest 2010

Horacio Bach

Infectious Diseases

1 shared papers, latest 2019

Mikko Taipale

Donnelly Centre

1 shared papers, latest 2025

Elizabeth Conibear

Medical Genetics

1 shared papers, latest 2024

Daniela Rotin

Cell Biology

1 shared papers, latest 2014

Brian Raught

Research Institute

1 shared papers, latest 2025

Martin Hirst

Microbiology and Immunology

1 shared papers, latest 2017

Aly Karsan

Genome Sciences Centre

1 shared papers, latest 2023

David Fedida

Anesthesiology, Pharmacology and Therapeutics

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Ubiquitin Dear Professor Mayor, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Peptide barcoding: an alternative to the phenotype-genotype problem." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Molecular Principles Governing Degron Recognition in Misfolded Cytosolic Proteins with Pathological Missense Mutations" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Thibault Mayor

Research

Latest papers

Latest funding

Peptide barcoding: an alternative to the phenotype-genotype problem.

A direct role for a mitochondrial targeting sequence in signalling stress.

Mining yeast diversity unveils novel targets for improved heterologous laccase production in Saccharomyces cerevisiae.

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations.

Lost in translation: Threonine dictates aggregation of CAT tails.

Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae.

Shift of the insoluble content of the proteome in the aging mouse brain.

Identification of newly translated thermo-sensitive proteins using pulse SILAC mass spectrometry and the GAL promoter system.

Comparison of Biomolecular Condensate Localization and Protein Phase Separation Predictors.

Pulse labeling reveals the tail end of protein folding by proteome profiling.

Molecular Principles Governing Degron Recognition in Misfolded Cytosolic Proteins with Pathological Missense Mutations

Elucidation of the client repertoires and functions of the two related DNAJB6 and B8 co-chaperones

Investigation of Pathways that Regulate the Expression of Recombinant Proteins in Yeast

Identifying key E3 ubiquitin ligases that target disease-associated mutant cytosolic proteins for degradation

High throughput flow cytometer for the Michael Smith Laboratories

Examining the Ubiquitin Machinery in Genetic Diseases of Protein Misfolding

Proteostasis Researchers in Canada, Eh (PRinCE) Inaugural Meeting

Characterization of quality control pathways that target cytosolic misfolded proteins with missense mutations for proteasome degradation

Analysis of the proteostasis network and the thermostability of the proteome

Characterization of the proteostasis decline upon aging

Frequent collaborators

Vivien Measday

Corey Nislow

Christopher Loewen

Michel Roberge

Horacio Bach

Mikko Taipale

Yossef Av-Gay

Elizabeth Conibear

Michael Pollak

Sabine Gilch

Hilla Weidberg

Hongbin Li

Daniela Rotin

Kevin Wei

Brian Raught

Martin Hirst

Aly Karsan

David Fedida