Faculty profile
Christopher Overall
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Latest papers
Finerenone prevents renal damage by enhancing SDF-1α/CXCR4-mediated stem cell mobilization in experimental type 1 diabetic nephropathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
The Journal of biological chemistry · 2011 · senior author
Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice.
Circulation · 2008
Latest funding
- $100,000
Acute human gingivitis systems biology
CIHR · 2023 · Nominated PI
- $100,000
Acute human gingivitis systems biology
CIHR · 2022 · Nominated PI
- $50,000
COVID-19 Variant Supplement - Host cellular protein substrates of SARS-CoV-2 proteases
CIHR · 2021 · Co-investigator
3 publications.
Finerenone prevents renal damage by enhancing SDF-1α/CXCR4-mediated stem cell mobilization in experimental type 1 diabetic nephropathy.
Palma-Guzmán P, Bragado-García E, Durán-Mateos E, Sanz-Gómez M, Overall C, Aranguez I, Mercado-García E, Ruiz-Hurtado G, Kreutz R, Plaza A, Merino JJ, Fernández-Alfonso MS
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C
Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice.
Cheung C, Marchant D, Walker EK, Luo Z, Zhang J, Yanagawa B, Rahmani M, Cox J, Overall C, Senior RM, Luo H, McManus BM
Acute human gingivitis systems biology
Principal investigators: Overall, Christopher M
Keywords: Biomarkers; Gingiva; Gingivitis; Inflammatory Diseases; Mmps; Pericoronitis; Periodontium; Proteases; Proteomics; Serpins
Acute human gingivitis systems biology
Principal investigators: Overall, Christopher M
Keywords: Arthritis; Gingivitis; Hmgb1; Inflammatory Diseases; Malt1; Matrix Metalloproteinase (Mmp); Nfkb; Pericoronitis; Proteomics
COVID-19 Variant Supplement - Host cellular protein substrates of SARS-CoV-2 proteases
Principal investigators: Jan, Eric
Keywords: Coronavirus; Innate Immune Response; Mass Spectrometry; Protease; Rna; Substrate Specificity; Virus; Virus Host Interactions
Host cellular protein substrates of SARS-CoV-2 proteases
Principal investigators: Jan, Eric
Keywords: Coronavirus; Innate Immune Response; Mass Spectrometry; Protease; Rna; Substrate Specificity; Virus; Virus Host Interactions
Sex as a Biological Variable Supplement - Host cellular protein substrates of SARS-CoV-2 proteases
Principal investigators: Jan, Eric
Keywords: Coronavirus; Innate Immune Response; Mass Spectrometry; Protease; Rna; Substrate Specificity; Virus; Virus Host Interactions
Matrix Metalloproteinase cleavage of PCSK9 in Atherosclerosis
Principal investigators: Grin, Peter M
Keywords: Atherosclerosis; Cardiovascular Disease; Chronic Inflammation; Hypercholesterolemia; Ldl-Cholesterol; Matrix Metalloproteinases; Pcsk9; Proteolytic Processing
Host cell protein substrates of enterovirus proteases
Principal investigators: Jan, Eric
Keywords: Cleavage; Coxsackievirus; Enterovirus; Poliovirus; Protease; Proteomics; Replication; Virus
Expanding the degradome of matrix metalloproteinase 1 (MMP1) using N-terminomics
Principal investigators: Bulka, Olivia
Keywords: Arthritis; Collagenase; Degradomics; Inflammation; Matrix Metalloprotease 1; Mmp-1; N-Terminomics; Protease; Proteomics; Substrates
Discovering novel biomarkers for juvenile arthritis: focus on platelet signaling
Principal investigators: Kim, Hugh
Keywords: Biomarkers; Inflammation; Juvenile Arthritis; Platelets
Deciphering the regulation of extracellular high mobility group box 1 (HMGB1) activity by matrix metalloproteinases (MMPs) in periodontal inflammation
Principal investigators: Overall, Christopher M
Keywords: Connective Tissue / Extracellular Matrix (Ecm); Diagnostic Tests / Biomarker Discovery; Gingiva / Gingivitis; High Mobility Group Box 1 (Hmgb1); Inflammatory Disease / Arthritis; Neo-Epitope Antibodies / Selected Reaction Monitoring (Srms); Periodontitis / Periodontal Disease; Proteases / Matrix Metalloproteinases (Mmp); Proteomics / Degradomics / Systems Biology; Sepsis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Oral Biological & Medical Sciences
- Cellular and Physiological Sciences
- Pathology and Laboratory Medicine
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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