Faculty profile
Calvin Roskelley
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Research
Latest papers
Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFβ1 Promotes Tumour Growth.
Biology · 2022
Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.
PLoS neglected tropical diseases · 2016
Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin.
The Journal of nutritional biochemistry · 2013
Latest funding
- $100,000
Podocalyxin's role in tumor invasion, metastasis, and immune evasion
CIHR · 2022 · Principal investigator
- $963,900
Targeting ovarian carcinoma using the cell surface glycoprotein podocalyxin.
CIHR · 2019 · Nominated PI
- $100,000
Caveolin-1 regulation of focal adhesion tension and the breast cancer cell response to matrix stiffness
CIHR · 2018 · Co-investigator
8 publications.
Epithelial-Mesenchymal Plasticity Induced by Discontinuous Exposure to TGFβ1 Promotes Tumour Growth.
Santos M, Ferreira M, Oliveira P, Mendes N, André A, Vieira AF, Nunes JB, Carvalho J, Rocha S, Azevedo M, Ferreira D, Reis I, Vinagre J, Paredes J, Heravi-Moussavi A, Lima J, Máximo V, Burleigh A, Roskelley C, Carneiro F, Huntsman D, Oliveira C
Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.
Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, Roskelley C, Forge T, Nislow C, Moerman D
Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin.
Lymburner S, McLeod S, Purtzki M, Roskelley C, Xu Z
A novel subcellular machine contributes to basal junction remodeling in the seminiferous epithelium.
Du M, Young J, De Asis M, Cipollone J, Roskelley C, Takai Y, Nicholls PK, Stanton PG, Deng W, Finlay BB, Vogl AW
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.
Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, Overall CM, Minchinton A, Pacchiano F, Carta F, Scozzafava A, Touisni N, Winum JY, Supuran CT, Dedhar S
Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis.
Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S
Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.
Filipenko NR, Attwell S, Roskelley C, Dedhar S
Podocalyxin's role in tumor invasion, metastasis, and immune evasion
Principal investigators: McNagny, Kelly M; Roskelley, Calvin D
Keywords: Breast Cancer; Cancer Therapy; Glycosylation; Immunolgy; Invasion; Metastasis; Ovarian/Fallopian Tube Cancer; Podocalyxin; Trangenic Mice; Tumor Stem Cells
Targeting ovarian carcinoma using the cell surface glycoprotein podocalyxin.
Principal investigators: Roskelley, Calvin D; McNagny, Kelly M
Keywords: Antibody; Antibody Drug Conjugate; Cancer Biomarker; Chimeric Antigen Receptor; Ovarian Carcinoma; Pre-Clinical Drug Development; Radioimmunotherapy
Caveolin-1 regulation of focal adhesion tension and the breast cancer cell response to matrix stiffness
Principal investigators: Nabi, Ivan R
Keywords: Breast Cancer; Caveolin-1; Extracellular Matrix Stiffness; Focal Adhesions; Membrane Domains; Metastasis; Single Molecule Localization Microscope; Super Resolution Microscopy; Tumor Cell Migration; Vinculin Tension
Caveolin-1 regulation of focal adhesion tension and the breast cancer cell response to matrix stiffness
Principal investigators: Nabi, Ivan R
Keywords: Caveolin-1; Extracellular Matrix Stiffness; Focal Adhesions; Mechanical Stress; Membrane Domains; Metastasis; Single Molecule Localization Microscope; Super Resolution Microscopy; Tumor Cell Migration; Vinculin
Targeting novel acid stress resistance mechanisms in cancer cell metabolism
Principal investigators: Loewen, Christopher
Keywords: Ap-3 Adapter Complex; Breast Cancer; Cancer Cell Metabolism; Glycolytic Phenotype; Intracellular Acid Stress; Lysosomes; Mitochondria; Oxidative Phosphorylation; P Bodies; Pan Deadenylase Complex
The role of hyaluronan in priming and populating the inflammatory micrometastatic niche.
Principal investigators: Roskelley, Calvin D
Keywords: Cancer; Extracellular Matrix; Metastasis; Niche
Preclinical Development Of Inhibitors Of Podocalyxin-Driven Tumor Progression
Principal investigators: Roskelley, Calvin D
Keywords: Breast Cancer; Invasion; Metastasis; Ovarian Cancer
Hydrogel-based microfluidic cell culture system for controlled drug dosage effects
Principal investigators: Cheung, Karen
Hydrogel-based microfluidic cell culture system for controlled drug dosage effects
Principal investigators: Cheung, Karen C
Keywords: Microfluidics
Regulation of cell migration by a Rap1 GTPase-dependent sensor of extracellular matrix density that controls cytoskeletal and focal adhesion dynamics.
Principal investigators: Roskelley, Calvin D; Gold, Michael R
Keywords: Cell Adhesion; Cell Migration; Cytoskeleton; Intravital Imaging; Live Cell Imaging; Protein-Protein Interaction
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Calvin Roskelley and Shoukat Dedhar: 3 shared papers
- David Huntsman and Calvin Roskelley: 2 shared papers
- David Huntsman and Shoukat Dedhar: 2 shared papers
- Shoukat Dedhar and Michel Roberge: 2 shared papers
- Shoukat Dedhar and Marcel Bally: 2 shared papers
- Andrew Minchinton and Marcel Bally: 2 shared papers
- Michel Roberge and Corey Nislow: 2 shared papers
- David Huntsman and Andrew Minchinton: 1 shared paper
- David Huntsman and Marcel Bally: 1 shared paper
- Calvin Roskelley and Christopher Overall: 1 shared paper
- Calvin Roskelley and Andrew Minchinton: 1 shared paper
- Calvin Roskelley and Michel Roberge: 1 shared paper
- Calvin Roskelley and Corey Nislow: 1 shared paper
- Calvin Roskelley and Donald Moerman: 1 shared paper
- Calvin Roskelley and Marcel Bally: 1 shared paper
- Calvin Roskelley and Audrey Tung: 1 shared paper
- Michel Roberge and Donald Moerman: 1 shared paper
- Michel Roberge and Audrey Tung: 1 shared paper
- Corey Nislow and Donald Moerman: 1 shared paper
- Corey Nislow and Audrey Tung: 1 shared paper
- Biochemistry and Molecular Biology
- Cellular and Physiological Sciences
- Molecular Oncology
- Oral Biological & Medical Sciences
- Zoology
- Experimental Therapeutics
- Other
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Shoukat Dedhar
Biochemistry and Molecular Biology
3 shared papers, latest 2011
David Huntsman
Molecular Oncology
2 shared papers, latest 2022
Andrew Minchinton
Faculty
1 shared papers, latest 2011
Michel Roberge
Biochemistry and Molecular Biology
1 shared papers, latest 2016
Corey Nislow
Faculty
1 shared papers, latest 2016
Donald Moerman
Zoology
1 shared papers, latest 2016
Marcel Bally
Experimental Therapeutics
1 shared papers, latest 2011
Christopher Overall
Oral Biological & Medical Sciences
1 shared papers, latest 2011
Audrey Tung
Faculty
1 shared papers, latest 2016
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