Fumio Takei, University of British Columbia

Research

Fibrosis Hepatitis Lymphocyte Development Innate Lymphocytes Asthma Innate Lymphoid Cell Sex Hormone Alcohol

Latest papers

Human CD127 negative ILC2s show immunological memory.
The Journal of experimental medicine · 2024
New insights into ILC2 memory.
Immunological reviews · 2024 · senior author
Flow cytometric analysis of innate lymphoid cells: challenges and solutions.
Frontiers in immunology · 2023 · senior author

All 44 publications

Latest funding

ILC6 - The 6th International Conference on Innate Lymphoid Cells
CIHR · 2025 · Co-investigator
$10,000
Innate lymphoid cells in hepatitis and liver fibrosis
CIHR · 2023 · Nominated PI
$814,726
Tissue resident and migratory group 2 innate lymphoid cells in health and disease
CIHR · 2020 · Nominated PI
$784,126

All 13 grants and awards

44 publications.

01

Human CD127 negative ILC2s show immunological memory.

Mathä L, Krabbendam L, Martinez Høyer S, Heesters BA, Golebski K, Kradolfer C, Ghaedi M, Ma J, Stadhouders R, Bachert C, Cardell LO, Zhang N, Holtappels G, Reitsma S, Helgers LC, Geijtenbeek TBH, Coquet JM, Takei F, Spits H, Martinez-Gonzalez I

The Journal of experimental medicine2024

DOI: 10.1084/jem.20231827 PMID: 38889332

02

New insights into ILC2 memory.

Martinez-Gonzalez I, Takei F

Immunological reviews2024Senior author

DOI: 10.1111/imr.13323 PMID: 38506432

03

Flow cytometric analysis of innate lymphoid cells: challenges and solutions.

Sadeghalvad M, Khijakadze D, Orangi M, Takei F

Frontiers in immunology2023Senior author

DOI: 10.3389/fimmu.2023.1198310 PMID: 37809100

04

Tissue Resident and Migratory Group 2 Innate Lymphoid Cells.

Mathä L, Takei F, Martinez-Gonzalez I

Frontiers in immunology2022

DOI: 10.3389/fimmu.2022.877005 PMID: 35572538

05

Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity.

Mathä L, Romera-Hernández M, Steer CA, Yin YH, Orangi M, Shim H, Chang C, Rossi FM, Takei F

Frontiers in immunology2021Senior author

DOI: 10.3389/fimmu.2021.679509 PMID: 34305911

06

Innate lymphoid cell development.

Ghaedi M, Takei F

The Journal of allergy and clinical immunology2021Senior author

DOI: 10.1016/j.jaci.2021.03.009 PMID: 33965092

07

The Fate of Activated Group 2 Innate Lymphoid Cells.

Mathä L, Martinez-Gonzalez I, Steer CA, Takei F

Frontiers in immunology2021Senior author

DOI: 10.3389/fimmu.2021.671966 PMID: 33968080

08

Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors.

Shin SB, Lo BC, Ghaedi M, Scott RW, Li Y, Messing M, Hernaez DC, Cait J, Murakami T, Hughes MR, Leslie KB, Underhill TM, Takei F, McNagny KM

Blood advances2020

DOI: 10.1182/bloodadvances.2020002758 PMID: 33137203

09

Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period.

Steer CA, Mathä L, Shim H, Takei F

JCI insight2020Senior author

DOI: 10.1172/jci.insight.135961 PMID: 32573494

10

Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets.

Ghaedi M, Shen ZY, Orangi M, Martinez-Gonzalez I, Wei L, Lu X, Das A, Heravi-Moussavi A, Marra MA, Bhandoola A, Takei F

The Journal of experimental medicine2020Senior author

DOI: 10.1084/jem.20182293 PMID: 31816636

ILC6 - The 6th International Conference on Innate Lymphoid Cells

Co-investigatorCIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Mortha, Arthur

Keywords: Immunology

$10,000

Innate lymphoid cells in hepatitis and liver fibrosis

Nominated PICIHR2023Project Grant

Principal investigators: Takei, Fumio

Keywords: Alcohol; Fatty Liver; Fibrosis; Hepatitis; High Fat Diet; Innate Lymphoid Cells

$814,726

Tissue resident and migratory group 2 innate lymphoid cells in health and disease

Nominated PICIHR2020Project Grant

Principal investigators: Takei, Fumio

Keywords: Fibrosis; Hepatitis; Innate Lymphocytes; Liver; Lung; Lymphocyte Development; Migration; Neonate; Tissue Resident

$784,126

CD127 in the development and function of Type 2 Innate Lymphoid Cells (ILC2s).

Co-investigatorCIHR2017Project Grant

Principal investigators: Abraham, Ninan

Keywords: Airway Immunity; Asthma And Influenza; Conditional Knockout; Cytokine Receptors; Il-7 And Tslp; Ilc2; Immune Development; Innate Lymphoid Cells; Tissue Repair; Transcriptional Programs

$1,036,575

Sex differences in innate lymphoid cells and asthma

Nominated PICIHR2017Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Takei, Fumio

Keywords: Asthma; Cytokine; Innate Lymphoid Cell; Sex Difference; Sex Hormone; Type 2 Inflammation

$150,000

Immunological memory of innate lymphoid cells and allergic lung inflammation

Nominated PICIHR2016Project Grant

Principal investigators: Takei, Fumio

Keywords: Allergic Lung Inflammation; Cytokines; Immunological Memory; Innate Lymphocytes; Lung Immunity; Neonatal Immunity

$822,375

Gender differences in innate lymphoid cells and asthma

Nominated PICIHR2015Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Takei, Fumio

Keywords: Asthma; Gender; Innate Lymphoid Cell; Sex Hormone

$150,000

Regulation of adult type 2 immunity by neonatal ILC2s

SupervisorCIHR2015Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Steer, Catherine

Keywords: Allergy; Flow Cytometry; Germ-Free Mice; Group 2 Innate Lymphocytes (Ilc2s); Hygiene Hypothesis; Interleukin-33 (Il-33); Lipopolysaccaride (Lps); Neonates; Type 2 Immunity

$105,000

Immunologial memory of innate lymphocytes and allergic lung inflammation

SupervisorCIHR2014CIHR Fellowship

Principal investigators: Martinez-Gonzalez, Itziar

Keywords: Asthma; Flow Cytometry; Innate Lymphoid Cells; Memory; Type 2 Inflammation

$93,750

Innate lymphocyte development

Nominated PICIHR2012Operating Grant

Principal investigators: Takei, Fumio

Keywords: Bone Marrow Stem Cells; Common Lymphoid Progenitor; Innate Lymphocyte; Lymphocyte Development; Natural Helper Cell; Natural Killer Cell

$654,615

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Terry Fox Laboratory
Biomedical Research Centre
Microbiology and Immunology
Experimental Therapeutics

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Colby Zaph

Biomedical Research Centre

1 shared papers, latest 2016

William Jia

Experimental Therapeutics

1 shared papers, latest 2016

Ninan Abraham

Microbiology and Immunology

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Fibrosis Dear Professor Takei, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Human CD127 negative ILC2s show immunological memory." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Innate lymphoid cells in hepatitis and liver fibrosis" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Fumio Takei

Research

Latest papers

Latest funding

Human CD127 negative ILC2s show immunological memory.

New insights into ILC2 memory.

Flow cytometric analysis of innate lymphoid cells: challenges and solutions.

Tissue Resident and Migratory Group 2 Innate Lymphoid Cells.

Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity.

Innate lymphoid cell development.

The Fate of Activated Group 2 Innate Lymphoid Cells.

Abortive &#x3b3;&#x3b4;TCR rearrangements suggest ILC2s are derived from T-cell precursors.

Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period.

Single-cell analysis of ROR&#x3b1; tracer mouse lung reveals ILC progenitors and effector ILC2 subsets.

Frequent collaborators

Colby Zaph

William Jia

Ninan Abraham

Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors.

Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets.