Faculty profile

Colby Zaph

ResearcherBiomedical Research CentreUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Colby Zaph

Researcher

Biomedical Research Centre

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
No publications since 2018.
Principal investigator on 4 research grants (4 CIHR), most recently in 2013.
Supervised 4 trainees who won CIHR awards, most recently in 2011.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Beta-Catenin Cancer Cell Biology Hippo Pathway Intestine Liver Lysine Methylation Organoids

Latest papers

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.
PLoS pathogens · 2018 · senior author
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Cell stem cell · 2018
Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.
American journal of respiratory cell and molecular biology · 2017

All 21 publications

Latest funding

Regulation of intestinal homeostasis and cancer by the lysine methyltransferase Set7
CIHR · 2013 · Nominated PI
$795,064
ImmunoVancouver 2013
CIHR · 2012 · Co-investigator
$6,529
Influence of the Microbiome on Epigenetic Mechanisms in Inflammatory Bowel Disease (IBD)
CIHR · 2012 · Co-investigator
$1,425,000

All 13 grants and awards

21 publications.

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.

Burrows K, Antignano F, Chenery A, Bramhall M, Korinek V, Underhill TM, Zaph C

PLoS pathogens2018Senior author

DOI: 10.1371/journal.ppat.1006869 PMID: 29470558

Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Judson RN, Quarta M, Oudhoff MJ, Soliman H, Yi L, Chang CK, Loi G, Vander Werff R, Cait A, Hamer M, Blonigan J, Paine P, Doan LTN, Groppa E, He W, Su L, Zhang RH, Xu P, Eisner C, Low M, Barta I, Lewis CB, Zaph C, Karimi MM, Rando TA, Rossi FM

Cell stem cell2018

DOI: 10.1016/j.stem.2017.12.010 PMID: 29395054

Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.

Lo BC, Gold MJ, Scheer S, Hughes MR, Cait J, Debruin E, Chu FSF, Walker DC, Soliman H, Rossi FM, Blanchet MR, Perona-Wright G, Zaph C, McNagny KM

American journal of respiratory cell and molecular biology2017

DOI: 10.1165/rcmb.2016-0386oc PMID: 28683207

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

Scheer S, Medina TS, Murison A, Taves MD, Antignano F, Chenery A, Soma KK, Perona-Wright G, Lupien M, Arrowsmith CH, De Carvalho DD, Zaph C

Journal of leukocyte biology2017Senior author

DOI: 10.1189/jlb.3ma0716-334rr PMID: 28034915

Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.

Chenery AL, Antignano F, Hughes MR, Burrows K, McNagny KM, Zaph C

European journal of immunology2016Senior author

DOI: 10.1002/eji.201646326 PMID: 27594558

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.

Oudhoff MJ, Antignano F, Chenery AL, Burrows K, Redpath SA, Braam MJ, Perona-Wright G, Zaph C

PLoS pathogens2016Senior author

DOI: 10.1371/journal.ppat.1005876 PMID: 27598373

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

Antignano F, Braam M, Hughes MR, Chenery AL, Burrows K, Gold MJ, Oudhoff MJ, Rattray D, Halim TY, Cait A, Takei F, Rossi FM, McNagny KM, Zaph C

The Journal of experimental medicine2016Senior author

DOI: 10.1084/jem.20151646 PMID: 27298444

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JH, Owen DR, Brown PJ, Zaph C

Developmental cell2016Senior author

DOI: 10.1016/j.devcel.2016.03.002 PMID: 27046831

Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.

Chenery AL, Antignano F, Burrows K, Scheer S, Perona-Wright G, Zaph C

Infection and immunity2016Senior author

DOI: 10.1128/iai.01240-15 PMID: 26644379

Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice.

Gold MJ, Antignano F, Hughes MR, Zaph C, McNagny KM

European journal of immunology2016

DOI: 10.1002/eji.201545628 PMID: 26518471

Regulation of intestinal homeostasis and cancer by the lysine methyltransferase Set7

Nominated PICIHR2013Operating Grant

Principal investigators: Zaph, Colby

Keywords: Beta-Catenin; Cancer; Cell Biology; Hippo Pathway; Intestine; Liver; Lysine Methylation; Organoids; Set7; Wnt Pathway

$795,064

ImmunoVancouver 2013

Co-investigatorCIHR2012Dissemination Events - Priority Announcement: Infection and Immunity

Principal investigators: Choy, Jonathan C; Pantophlet, Ralph A

Keywords: Cancer; Chronic Diseases; Diabetes; Hiv; Immunology; Immunotherapy; Inflammation; Interdisciplinary Collaborations; Vaccines

$6,529

Influence of the Microbiome on Epigenetic Mechanisms in Inflammatory Bowel Disease (IBD)

Co-investigatorCIHR2012Team Grant: CEEHRC - Full application

Principal investigators: Arrowsmith, Cheryl H

Keywords: Chemical Probes; Chip-Seq; Colitis; Colitis-Associated Cancer; Epigenetics; Epigenomic Mapping; Inflammatory Bowel Disease; Microbiota; Mouse Models; T-Cell Differentiation

$1,425,000

Regulation of the Hippo pathway by the methyltransferase Set7 in the gut during homeostasis and disease

SupervisorCIHR2011Fellowship - Priority Announcement - Inflammatory Bowel Disease

Principal investigators: Oudhoff, Menno J

Keywords: Epigenetics; Epithelial Cell Biology; Immunology; Inflammatory Bowel Disease; Large And Small Intestine; Parasite Immunology; Stem Cell Biology

$45,000

ImmunoVancouver 2012

Co-investigatorCIHR2011Dissemination Events - Priority Announcement: Cancer Research

Principal investigators: Choy, Jonathan C; Pantophlet, Ralph A

Keywords: Cancer; Chronic Diseases; Diabetes; Hiv; Immunology; Inflammation; Interdisciplinary Collaborations

$12,750

Epigenetic regulation of CD4+ T cell dependent immunity and inflammation

SupervisorCIHR2010Fellowship - Priority Announcement - Inflammatory Bowel Disease

Principal investigators: Antignano, Frann

Keywords: Conditional Deletion Mouse Model; Cytokine Biology; Epigenetics; Helminth Immunity; Helper T Cells; Immunoparasitology; Inflammatory Bowel Disease; Lysine-Methyltransferase (G9a And Set7); Mucosal Immunity

$45,000

Immuno-Vancouver 2011

Co-investigatorCIHR2010Planning Grants - Priority Announcement: Infection and Immunity

Principal investigators: Levings, Megan K; Gold, Michael R

Keywords: Autimmunity; Brainstorming Sessions; Cell-Cell Interactions; Immunology; Interdisciplinary Collaborations

$10,815

Histone methyltransferase-dependent regulation of T helper cell differentiation and function

Nominated PICIHR2010Operating Grant

Principal investigators: Zaph, Colby

Keywords: Asthma; Cd4 T Cells; Chromatin; Colitis; Epigenetics; G9a And Set7; Helminth Infection; Histone Lysine Methyltransferase; T Cell Memory; T Cell Plasticity

$554,104

Immuno-Vancouver 2010 meeting

Co-investigatorCIHR2009Planning Grants - Priority Announcement: Infection and Immunity

Principal investigators: Gold, Michael R; Levings, Megan K

Keywords: Autoimmunity; Brainstorming Sessions; Cell-Cell Interactions; Immunology; Interdisciplinary Collaborations

$6,131

Fibrosis: cellular origins and therapeutic strategies

Principal investigatorCIHR2009Emerging Team Grant: Regenerative Medicine and Nanomedicine - LOI

Principal investigators: Rossi, Fabio M; Kast, Juergen; Knight, Darryl A; McManus, Bruce M; McNagny, Kelly M; Underhill, Michael; Vallance, Bruce A; Zaph, Colby

Keywords: Chronic Inflammation; Fibrosis (Multiple Diseases); Genetic Disease; Regenerative Medicine

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Colby Zaph

Research

Latest papers

Latest funding

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.

Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.

Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice.

Regulation of intestinal homeostasis and cancer by the lysine methyltransferase Set7

ImmunoVancouver 2013

Influence of the Microbiome on Epigenetic Mechanisms in Inflammatory Bowel Disease (IBD)

Regulation of the Hippo pathway by the methyltransferase Set7 in the gut during homeostasis and disease

ImmunoVancouver 2012

Epigenetic regulation of CD4+ T cell dependent immunity and inflammation

Immuno-Vancouver 2011

Histone methyltransferase-dependent regulation of T helper cell differentiation and function

Immuno-Vancouver 2010 meeting

Fibrosis: cellular origins and therapeutic strategies

Frequent collaborators

Georgia Perona-Wright

Dalia Barsyte-Lovejoy

Matthieu Schapira

Ahmed Aman

Jeremy Hirota

Anne-Claude Gingras

Fumio Takei

Mathieu Lupien

Colby Zaph

Research

Latest papers

Latest funding

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.

Inhibition of Methyltransferase Setd7 Allows the In&#xa0;Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation.

Chronic Trichuris muris infection alters hematopoiesis and causes IFN-&#x3b3;-expressing T-cell accumulation in the mouse bone marrow.

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection.

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/&#x3b2;-Catenin and Hippo/YAP Signaling.

Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.

Dendritic-cell expression of Ship1 regulates Th2 immunity to helminth infection in mice.

Frequent collaborators

Georgia Perona-Wright

Dalia Barsyte-Lovejoy

Matthieu Schapira

Ahmed Aman

Jeremy Hirota

Anne-Claude Gingras

Fumio Takei

Mathieu Lupien

Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.

Chronic Trichuris muris infection alters hematopoiesis and causes IFN-γ-expressing T-cell accumulation in the mouse bone marrow.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.